Browsing Brody School of Medicine by Author "Neufer, P. Darrell"
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Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
Alleman, Rick J. (East Carolina University, 2016-05-03)Coronary heart disease is a leading cause of death in the United States, totaled mostly by deaths associated with myocardial infarction and fatal ventricular arrhythmias. The inability to predict the occurrence of these ... -
Deciphering the impact of fructose metabolism on liver mitochondrial bioenergetics
Buddo, Katherine A (East Carolina University, 2021-12-07)Since its discovery in 1980, the interest in nonalcoholic fatty liver disease, the liver manifestation of metabolic syndrome, has expanded due to the growing impact on the world's health. Commonly characterized by ... -
Enhanced Mitochondrial Superoxide Scavenging Does Not Improve Muscle Insulin Action in the High Fat-Fed Mouse
Lark, Daniel Stephen; Kang, Li; Lustig, Mary E.; Bonner, Jeffrey S.; James, Freyja D.; Neufer, P. Darrell; Wasserman, David H. (2015-05)Improving mitochondrial oxidant scavenging may be a viable strategy for the treatment of insulin resistance and diabetes. Mice overexpressing the mitochondrial matrix isoform of superoxide dismutase (sod2tg mice) and/or ... -
Estrogen Receptor-α in Female Skeletal Muscle is Not Required for Regulation of Muscle Insulin Sensitivity and Mitochondrial Regulation
McClung, Joseph M.; Iñigo, Melissa R.; Amorese, Adam J.; Tarpey, Michael D.; Balestrieri, Nicholas P.; Jones, Keith G.; Patteson, Daniel J.; Torres, Maria.J.; Lin, Chien-Te; Smith, Cody D.; Heden, Timothy D.; McMillin, Shawna L.; Weyrauch, Luke A.; Stanley, Erin C.; Schmidt, Cameron A.; Funai, Katsuhiko; Gowdy, Kymberly M.; Witczak, Carol A.; Neufer, P. Darrell; Spangenburg, Espen E. (2020-04-01) -
Exercise-Induced Protection Against Reperfusion Arrhythmia Involves Stabilization of Mitochondrial Energetics
Spangenburg, Espen; Alleman, Rick J.; Tsang, Alvin M.; Ryan, Terence E.; Patteson, Daniel J.; McClung, Joseph M.; Shaikh, Saame Raza; Neufer, P. Darrell; Brown, David A. (2016-05-15) -
Extensive Skeletal Muscle Cell Mitochondriopathy Distinguishes Critical Limb Ischemia Patients from Claudicants
McClung, Joseph M.; Ryan, Terence E.; Yamaguchi, Dean J.; Schmidt, Cameron A.; Zeczycki, Tonya N.; Brophy, Patricia; Green, Thomas D.; Tarpey, Michael D.; Karnekar, Reema; Goldberg, Emma J.; Neufer, P. Darrell; Spangenburg, Espen E. (2018-11-02) -
Genetically Increasing Flux Through b-Oxidation in Skeletal Muscle Increases Mitochondrial Reductive Stress and Glucose Intolerance
Smith, Cody D.; Lin, Chien-Te; McMillin, Shawna L.; Weyrauch, Luke A.; Schmidt, Cameron A.; Smith, Cheryl A.; Witczak, Carol; Neufer, P. Darrell; Kurland, Irwin J. (2021) -
Human Studies of Mitochondrial Biology Demonstrate an Overall Lack of Binary Sex Differences: A Multivariate Meta-Analysis
Fisher-Wellman, Kelsey H.; Neufer, P. Darrell; Junker, Alex (2022) -
Intrinsic OXPHOS Limitations Underlie Cellular Bioenergetics in Leukemia
Nelson, Margaret AM; McLaughlin, Kelsey L.; Hagen, James T.; Coalson, Hannah S.; Schmidt, Cameron; Kassai, Miki; Kew, Kimberly A.; McClung, Joseph M.; Neufer, P. Darrell (2021) -
Linking energy state to redox environment through mitochondrial redox circuits
Smith, Cody D (East Carolina University, 2016-11-16)Mitochondria are the primary producers of intracellular H2O2, an oxidant signaling molecule that has gained attention for its role in normal physiological processes and disease etiologies such as skeletal muscle insulin ... -
Metformin Improves Insulin Signaling in Obese Rats via Reduced IKK Action in a Fiber-Type Specific Manner
Bikman, Benjamin Thomas; Zheng, Donghai; Kane, Daniel A.; Anderson, Ethan; Woodlief, Tracey L.; Price, Jesse W.; Dohm, G. Lynis; Neufer, P. Darrell; Cortright, Ronald N. (2010)Metformin is a widely used insulin-sensitizing drug, though its mechanisms are not fully understood. Metformin has been shown to activate AMPK in skeletal muscle; however, its effects on the inhibitor of κB kinaseβ (IKKβ) ... -
Methods for Assessing Mitochondrial Function in Diabetes
Perry, Christopher G.R.; Kane, Daniel A.; Lanza, Ian R.; Neufer, P. Darrell (2013-04)A growing body of research is investigating the potential contribution of mitochondrial function to the etiology of type 2 diabetes. Numerous in vitro, in situ, and in vivo methodologies are available to examine various ... -
Methods for preventing or treating insulin resistance
Neufer, P. Darrell; Anderson, Ethan; Szeto, Hazel (2009-08-13)The invention provides methods of preventing or treating insulin resistance in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide having at least one ... -
Mitochondrial H₂O₂ emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
Anderson, Ethan; Lustig, Mary E.; Boyle, Kristen E.; Woodlief, Tracey L.; Kane, Daniel A.; Lin, Chien-Te; Price, Jesse W. III; Kang, Li; Rabinovitch, Peter S.; Szeto, Hazel H.; Houmard, Joseph A.; Cortright, Ronald N.; Wasserman, David H.; Neufer, P. Darrell (2009-03)High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction and oxidative stress have been ... -
Mitochondrial Respiratory Capacity and Content Are Normal in Young Insulin-Resistant Obese Humans
Fisher-Wellman, Kelsey H.; Weber, Todd M.; Cathey, Brook L.; Brophy, Patricia; Gilliam, Laura A. A.; Kane, Constance L.; Maples, Jill M.; Gavin, Timothy Patrick; Houmard, Joseph A.; Neufer, P. Darrell (2014-01)Considerable debate exists about whether alterations in mitochondrial respiratory capacity and/or content play a causal role in the development of insulin resistance during obesity. The current study was undertaken to ... -
Mitochondrial Therapy Improves Limb Perfusion and Myopathy Following Hindlimb Ischemia
McClung, Joseph; Ryan, Terence E.; Schmidt, Cameron A.; Alleman, Rick J.; Tsang, Alvin M.; Green, Thomas D.; Neufer, P. Darrell; Brown, David A. (2016-08-01) -
Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle
Fisher-Wellman, Kelsey H.; Mattox, Taylor A.; Thayne, Kathleen; Katunga, Lalage Adalaide; La Favor, Justin D.; Neufer, P. Darrell; Hickner, Robert C.; Wingard, Christopher J.; Anderson, Ethan (2013)Increased fatty acid availability and oxidative stress are physiological consequences of exercise (Ex) and a high-fat, high-sugar (HFHS) diet. Despite these similarities, the global effects of Ex are beneficial, whereas ... -
PFKFB3-Mediated Glycolysis Rescues Myopathic Outcomes in the Ischemic Limb
McClung, Joseph M.; Ryan, Terence E.; Spangenburg, Espen E.; Schmidt, Cameron A.; Tarpey, Michael D.; Amorese, Adam J.; Yamaguchi, Dean J.; Goldberg, Emma J.; Iñigo, Melissa M.R.; Karnekar, Reema; Brophy, Patricia; Green, Thomas D.; Neufer, P. Darrell; Fisher-Wellman, Kelsey H.; Spangenburg, Espen E. (2020-09-17) -
Skeletal Muscle Undergoes Fiber Type Metabolic Switch Without Myosin Heavy Chain Switch in Response to Defective Fatty Acid Oxidation
Pereyra, Andrea S.; Lin, Chien-Te; Spangenburg, Espen E.; Neufer, P. Darrell; Fisher-Wellman, Kelsey; Ellis, Jessica M.; Sanchez, Daniela Mesa; Laskin, Julia (2022-02-09) -
Targeted Expression of Catalase to Mitochondria Protects Against Ischemic Myopathy in High-Fat Diet-Fed Mice
McClung, Joseph; Ryan, Terence E.; Schmidt, Cameron A.; Green, Thomas D.; Spangenburg, Espen E.; Neufer, P. Darrell (2016-06-09)