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YC-1 Stimulates the Expression of Gaseous Monoxide-Generating Enzymes in Vascular Smooth Muscle Cells
(East Carolina University, 2009-01)
The benzylindazole derivative 3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole (YC-1) is an allosteric stimulator of soluble guanylate cyclase (sGC) that sensitizes the enzyme to the gaseous ligands carbon monoxide (CO) and ...
Cocaine Disrupts Pup-Induced Maternal Behavior in Juvenile and Adult Rats
(East Carolina University, 2007-11)
Impaired onset of maternal behavior in first generation rat dams was previously correlated with rearing by cocaine-treated dams and prenatal cocaine exposure. Pup-induced maternal behavior in non-lactating rats has not ...
Cranial Ultrasound Lesions in the NICU Predict Cerebral Palsy at Age 2 Years in Children Born at Extremely Low Gestational Age
(East Carolina University, 2009-01)
Our prospective cohort study of extremely low gestational age newborns evaluated the association of neonatal head ultrasound abnormalities with cerebral palsy at age 2 years. Cranial ultrasounds in 1053 infants were read ...
Effect of North American Ginseng on 137Cs-induced Micronuclei in Human Lymphocytes
(East Carolina University, 2008-12)
To explore the radioprotective effect of a standardized North American ginseng extract (NAGE) on human peripheral blood lymphocytes (PBL), a micronuclei (MN) assay was conducted in PBL obtained from 12 volunteers. NAGE ...
Bolstering Confidence in Obesity Prevention and Treatment Counseling for Resident and Community Pediatricians
(East Carolina University, 2008-11)
Objective- To assess whether equipping resident pediatricians and community pediatricians with both training and practical tools improves their perceived confidence, ease, and frequency of obesity related counseling to ...
The cyclic GMP modulators YC-1 and zaprinast reduce vessel remodeling through anti-proliferative and pro-apoptotic effects
(East Carolina University, 2009-06)
Guanosine-specific cyclic nucleotide signaling is suggested to serve protective actions in the vasculature; however, the influence of selective pharmacologic modulation of cyclic guanosine monophosphate (GMP)-synthesizing ...
Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains
(East Carolina University, 2009-02-25)
Mutations in the DJ-1 gene have been linked to autosomal recessive familial Parkinson's disease. To understand the function of DJ-1, we determined the DJ-1 expression in both zebrafish and post mortem human brains. We found ...
Results From the Periodontitis and Vascular Events (PAVE) Study: A Pilot Multicentered, Randomized, Controlled Trial to Study Effects of Periodontal Therapy in a Secondary Prevention Model of Cardiovascular Disease
(East Carolina University, 2009-02)
Background- In the Periodontitis and Vascular Events (PAVE) pilot study, periodontal therapy was provided as an intervention in a secondary cardiac event prevention model through five coordinated cardiac-dental centers. ...
delta-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles
(East Carolina University, 2009-03-10)
Background: delta-Catenin is a unique member of delta-catenin/armadillo domain superfamily proteins and its primary expression is restricted to the brain. However, delta-catenin is upregulated in human prostatic adenocarcinomas, ...
Identification of Extracellular d-Catenin Accumulation for Prostate Cancer Detection
(East Carolina University, 2009-03-01)
BACKGROUND—Prostate cancer is the second leading cause of cancer death in men, and early
detection is essential to reduce mortality and increase survival. δ-Catenin is a unique β-catenin
superfamily protein primarily ...