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The heart healthy lenoir project-an intervention to reduce disparities in hypertension control: study protocol
(2013)
Background
Racial disparities in blood pressure control are well established; however the impact of low health literacy (LHL) on blood pressure has garnered less attention. Office based interventions that are created with ...
CD44 and hyaluronan promote the bmp7 signaling response in chondrocytes
(East Carolina University, 2011)
Cell-matrix interactions are important in maintaining cartilage homeostasis. Hyaluronan binding to its principal receptor CD44 is essential for such interactions. Hyaluronan-CD44 interactions are required for the retention ...
Antigen-specific tolerogenic vaccines inhibit autoimmune disease in a rodent model of multiple sclerosis
(East Carolina University, 2010)
Multiple sclerosis (MS) is considered to be a T cell-mediated autoimmune disease directed against myelinated nerves within the central nervous system. Current therapies available to MS patients have low efficacy and are ...
Investigations into the roles of bacteroides fragilis thioredoxins during the oxidative stress response
(East Carolina University, 2011)
The Gram-negative Bacteroides fragilis is the most frequently isolated bacterium from anaerobic infections. Native to the human intestinal tract, it serves a symbiotic role breaking down complex polysaccharides and ...
Perfluorooctanoic acid-induced developmental cardiotoxicity in an avian model
(East Carolina University, 2013)
Perfluorooctanoic acid (PFOA) is a synthetic chemical used in polyfluormer production. It is a widespread environmental contaminant and is known to induce developmental toxicity in rodent models. As several related compounds ...
Circadian activation of mast cells mediates the nocturnal response in allergic asthma
(East Carolina University, 2010)
Circadian rhythm is a conserved physiological feature of most organisms. Nocturnal symptoms are a common feature of allergic asthma in humans. Patients with nocturnal asthma show circadian variation of their pulmonary ...
The intracellular proteolytic fragment of CD44 alters CD44 function in chondrocytes
(East Carolina University, 2010)
CD44 is an adhesion molecule involved in several biological functions and the primary receptor for hyaluronan (HA). In cartilage, CD44 participates in the interplay between cells and the extracellular matrix to fine tune ...
The regulation of anthranilate synthesis for the production of pqs in pseudomonas aeruginosa
(East Carolina University, 2013)
The ubiquitous bacterium P. aeruginosa is an important human pathogen that causes devastating infections in immunocompromised patients and chronic infections in cystic fibrosis patients. The ability of P. aeruginosa to ...
The role of cardiac mitochondria in myocardial ischemia/reperfusion injury
(East Carolina University, 2012)
Cardiovascular disease (CVD) exerts economic and humanitarian costs that are unparalleled by any other disease. Of the many etiologies of CVD, myocardial infarction accounts for over 50% of the associated mortality and ...
Dopaminergic modulation of the autonomic nervous system: in vitro and in vivo evidence from the mouse
(East Carolina University, 2012)
Central nervous system (CNS) function depends on both the connections between the underlying neurons and neural circuits and their activity. Neuronal activity in turn can be classified as neurotransmission and neuromodulation, ...