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Kinetic and Thermodynamic Contributions to an Intermolecular Mechanism of Subunit Communication: Coordination of Pyruvate Carboxylase Activity Among Spatially Distinct Active Sites
(East Carolina University, 2016-07-13)
Catalysis occurring in a multifunctional enzyme at spatially distinct active sites is controlled by an array of factors, including the structure of the enzyme, ligand binding, and productive interaction of substrates to ...
Methods for Assessing Mitochondrial Function in Diabetes
(2013-04)
A growing body of research is investigating the potential contribution of mitochondrial function to the etiology of type 2 diabetes. Numerous in vitro, in situ, and in vivo methodologies are available to examine various ...
Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord
(2014-06)
Abstract
Dopamine (DA) modulates spinal reflexes, including nociceptive reflexes, in part via the D3 receptor subtype. We have previously shown that mice lacking the functional D3 receptor (D3KO) exhibit decreased paw ...
Estimation of Laceration Length by Emergency Department Personnel
(2014-11)
Introduction
Documentation and billing for laceration repair involves a description of wound length. We designed this study to test the hypothesis that emergency department (ED) personnel can accurately estimate wound ...
The Role of the Notch-3 Receptor in Stemness, EMT, and Tumorigenesis in Colorectal Cancer
(East Carolina University, 2016-05-05)
As the second leading cause of cancer death worldwide, colorectal cancer (CRC) poses a significant threat to both men and women alike. Although a small percentage of CRC cases are inherited, the majority of cases arise ...
PPP1R42 is a positive regulator of PP1 in centrosome duplication and separation and cilia dynamics
(East Carolina University, 2014)
The centrosome is a dynamic structure that undergoes structural and functional transitions, which are coordinated with the cell cycle. It functions as the microtubule organizing center (MTOC) in interphase, duplicates and ...
Congenital coronary artery anomalies silent until geriatric age: non-invasive assessment, angiography tips, and treatment
(2015-01)
Coronary artery anomalies (CAAs) may be discovered more often as incidental findings during the normal diagnostic process for other cardiac diseases or less frequently on the basis of manifestations of myocardial ischemia. ...
Discharge β-Blocker Use and Race after Coronary Artery Bypass Grafting
(2014-04)
Introduction: The use of discharge β-blockers after cardiac surgery is associated with a long-term mortality benefit. β-Blockers have been suggested to be less effective in black cardiovascular patients compared with whites. ...
Calcium Dependent CAMTA1 in Adult Stem Cell Commitment to a Myocardial Lineage
(2012)
The phenotype of somatic cells has recently been found to be reversible. Direct reprogramming of one cell type into another has been achieved with transduction and over expression of exogenous defined transcription factors ...