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The pseudorabies virus UL28 protein enters the nucleus after coexpression with the herpes simplex virus UL15 protein
(East Carolina University, 1997-12)
Herpesvirus DNA is packaged into capsids in the nuclei of infected cells in a process requiring at least six
viral proteins. Of the proteins required for encapsidation of viral DNA, UL15 and UL28 are the most conserved
among ...
PKR Regulates B56 alpha-mediated BCL2 Phosphatase Activity in Acute Lymphoblastic Leukemia-derived REH Cells
(East Carolina University, 2009-12-19)
Protein phosphatase 2A (PP2A) is a heterotrimer comprising catalytic, scaffold, and regulatory (B) subunits. There are at least 21 B subunit family members. Thus PP2A is actually a family of enzymes defined by which B ...
Intact Purine Biosynthesis Pathways Are Required for Wild-Type Virulence of Brucella abortus 2308 in the BALB/c Mouse Model
(East Carolina University, 2004-08)
Brucella abortus 2308 derivatives with mini-Tn5 insertions in purE, purL, and purD display significant attenuation in the BALB/c mouse model, while isogenic mutants with mini-Tn5 insertions in pheA, trpB, and dagA display ...
Present status and future direction of clinical trials in advanced endometrial carcinoma
(East Carolina University, 2008-09)
Endometrial adenocarcinoma is staged surgically, and advanced endometrial carcinoma is considered to be FIGO stage III and IV. The Gynecologic Oncology Group (GOG) has come a long way in developing new strategies in the ...
Pseudomonas aeruginosa relA Contributes to Virulence in Drosophila melanogaster
(East Carolina University, 2004-10)
The stringent response is a mechanism by which bacteria adapt to nutritional deficiencies through the production of the guanine nucleotides ppGpp and pppGpp, produced by the RelA enzyme. We investigated the role of the ...
Molecular basis for the immunosuppressive action of stearic acid on T cells.
(East Carolina University, 1990-07)
Studies were performed to determine the mechanism by which stearic acid (18: 0) selectively inhibits T-dependent immune responses in vitro. Incubation of mitogen-activated B and T cells with 18:0 resulted in dissimilar ...
Targeting prostate cancer based on signal transduction and cell cycle pathways
(East Carolina University, 2008-06-15)
Prostate cancer remains a leading cause of death in men despite increased capacity to diagnose at earlier stages. After prostate cancer has become hormone independent, which often occurs after hormonal ablation therapies, ...
Perfluorooctanoic acid-induced developmental cardiotoxicity in an avian model
(East Carolina University, 2013)
Perfluorooctanoic acid (PFOA) is a synthetic chemical used in polyfluormer production. It is a widespread environmental contaminant and is known to induce developmental toxicity in rodent models. As several related compounds ...
Pseudomonas aeruginosa PqsA Is an Anthranilate-Coenzyme A Ligase
(East Carolina University, 2008-02)
Pseudomonas aeruginosa is an opportunistic human pathogen which relies on several intercellular signaling systems for optimum population density-dependent regulation of virulence genes. The Pseudomonas quinolone signal ...
The ornithine decarboxylase gene odc is required for alcaligin siderophore biosynthesis in Bordetella spp.: putrescine is a precursor of alcaligin.
(East Carolina University, 1996-01)
Chromosomal insertions defining Bordetella bronchiseptica siderophore phenotypic complementation group III mutants BRM3 and BRM5 were found to reside approximately 200 to 300 bp apart by restriction mapping of cloned genomic ...