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Cardiovascular Outcomes Following Xenobiotic Pulmonary Exposures
(East Carolina University, 2017-07-06)
Cardiovascular disease remains the leading cause of mortality in the developed world. Over the past decades, investigations have demonstrated that pulmonary exposure to xenobiotic particulate matter promotes and exacerbates ...
A QUEST FOR ARTICULAR CARTILAGE PROGENITOR CELLS LEADS TO TEMPORAL REGULATION OF HYALURONAN REQUIRED FOR 3T3-L1 ADIPOGENESIS
(East Carolina University, 2017-07-13)
During embryogenesis, mesenchymal progenitor cells exhibit hyaluronan-dependent pericellular matrices as a major component of the extracellular matrix. As connective tissues form by cellular condensations, there is a loss ...
Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle
(2013)
Increased fatty acid availability and oxidative stress are physiological consequences of exercise (Ex) and a high-fat, high-sugar (HFHS) diet. Despite these similarities, the global effects of Ex are beneficial, whereas ...
MuRF1 activity is present in cardiac mitochondria and regulates reactive oxygen species production in vivo
(2014-06)
MuRF1 is a previously reported ubiquitin-ligase found in striated muscle that targets troponin I and myosin heavy chain for degradation. While MuRF1 has been reported to interact with mitochondrial substrates in yeast ...
Microglial dysfunction as an early susceptibility to Alzheimer's disease: the exacerbating role of developmental toxicity
(East Carolina University, 2017-07-25)
The association between perturbations to neuroimmune development and susceptibility to adult neurodegenerative diseases, like Alzheimer's disease (AD), may undersore a putative pathogenic role for gradual microglial ...
NOVEL ROLE OF HUMAN T-CELL LEUKEMIA VIRUS TYPE-1 ENCODED PROTEIN HBZ IN VIRAL TRANSMISSION THROUGH CELL-TO-CELL CONTACT
(East Carolina University, 2017-04-28)
The complex retrovirus Human T cell leukemia virus type I (HTLV-1) is the etiologic agent of several diseases, including Adult T cell leukemia (ATL), a fatal hematological malignancy that affects mainly CD4+ T-cells. Freshly ...
Neurotransmitter Metabolism by Monoamine Oxidase in Porcine Heart Differs by Location and is Increased with Obesity/Metabolic Syndrome
(East Carolina University, 2017-05-05)
Monoamine Oxidase (MAO), an outer mitochondrial enzyme, catalyzes the oxidative deamination of catecholamines and other biological amines, and in the process, produces a reactive aldehyde and H2O2. Our lab has recently ...
The Tumor Suppressive Effects of T Cell Death-Associated Gene 8 in Blood Cancers
(East Carolina University, 2017-03-16)
In the early twentieth century Otto Warburg recognized a metabolic phenomenon that transpired in cancer cells, currently known as the Warburg Effect. Warburg discovered cancer cells favor glycolysis rather than oxidative ...
The Influence of Diet-Induced Obesity and N-3 Fatty Acids on the Cardiac Mitochondrial Phospholipidome and Respiratory Activity
(East Carolina University, 2017-08-16)
Cardiac mitochondrial phospholipids, notably cardiolipin (CL), regulate inner mitochondrial membrane (IMM) organization and protein function, particularly the enzymes associated with respiration. In a range of metabolic ...