Browsing Open Access by Type"Article"
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THE 2016 MODEL OF THE CLINICAL PRACTICE OF EMERGENCY MEDICINE
(2017-06)Emergency medicine (EM) has a scientifically derived and commonly accepted description of the domain of its clinical practice. That document, “The Model of the Clinical Practice of Emergency Medicine” (EM Model), was ... -
The 3-Phosphoinositide-Dependent Protein Kinase 1 Inhibits Rod Photoreceptor Development
(2018-10-10)The transition of rod precursor cells to post-mitotic rod photoreceptors can be promoted by extrinsic factors such as insulin-like growth factor 1 (IGF- 1), which regulates phosphatidylinositide concentration, and consequently ... -
Abnormal Involuntary Movement Scale in Tardive Dyskinesia:Minimal Clinically Important Difference
(2019-05-27)Background A minimal clinically important difference has not been established for the Abnormal Involuntary Movement Scale in patients with tardive dyskinesia. Valbenazine is a vesicular monoamine transporter 2 inhibitor ... -
Acid ceramidase is upregulated in AML and represents a novel therapeutic target
(2016-12-13)There is an urgent unmet need for new therapeutics in acute myeloid leukemia (AML) as standard therapy has not changed in the past three decades and outcome remains poor for most patients. Sphingolipid dysregulation through ... -
Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
(2013-12-05)The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection ... -
Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells
(2017-01-27)Acidosis commonly exists in the tissue microenvironment of various pathophysiological conditions such as tumors, inflammation, ischemia, metabolic disease, and respiratory disease. For instance, the tumor microenvironment ... -
Actual neighborhood-level crime predicts body mass index z-score changes in a multi-racial/ethnic sample of children
(2018-09-24)Longitudinal studies are warranted to clarify the influence crime has on health outcomes in children especially children representing multiple racial/ethnic backgrounds. To address this need, the current study examined whether ... -
Adduction to arginine detoxifies aflatoxin B1 by eliminating genotoxicity and altering in vitro toxicokinetic profiles
(2018-01-12)Aflatoxin B1 (AFB1), a class 1 carcinogen and prominent food contaminant, is highly linked to the development of hepatocellular carcinoma (HCC) and plays a causative role in a large portion of global HCC cases. We have ... -
Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice
(2019-04-05)α-Klotho, a known anti-aging protein, exerts diverse physiological effects including: maintenance of phosphate and calcium homeostasis, modulation of cell proliferation, and enhanced buffering of reactive oxygen species. ... -
Adolescent BMI: The Importance of Intrinsic and Extrinsic Factors
(2018-04-13)Objectives: Research shows that weight trends in adolescence persist into adulthood, but do the same factors contribute to weight in adolescence as in adulthood? Are extrinsic factors presumably more important than ... -
Adolescent smoking: The relationship between cigarette consumption and BMI
(2018-12-07)Background:Studies relating cigarette smoking and body weight yield conflicting results. Weight-lowering effects in women and men have been associated with smoking, however, no effects on weight have been proven.This study ... -
Adults and Children in Low-Income Households That Participate in Cost-Offset Community Supported Agriculture Have High Fruit and Vegetable Consumption
(2017-07-08)This paper examines fruit and vegetable intake (FVI) in low-income households that participated in a cost-offset (CO), or 50% subsidized, community-supported agriculture (CSA) program. CSA customers paid farms upfront for ... -
Advanced immunostaining approaches to study early male germ cell development
(2018-02-09)Mammalian male germ cell development takes place in the testis under the influence of a variety of somatic cells and an incompletely defined paracrine and endocrine influences. Since it is not recapitulated well in vitro, ... -
Advances in Remote Sensing of Flooding
(2015-10)With the publication of eight original research articles, four types of advances in the remote sensing of floods are achieved. The uncertainty of modeled outputs using precipitation datasets derived from in situ observations ... -
Advancing research on racial-ethnic health disparities: Improving measurement equivalence in studies with diverse samples
(2014)To conduct meaningful, epidemiologic research on racial-ethnic health disparities, racial-ethnic samples must be rendered equivalent on other social status and contextual variables via statistical controls of those extraneous ... -
Affected Experiencers
(2012-08-21)Numerous languages permit an NP that is not selected by the verb to be added to a clause, with several different possible interpretations. We divide such non-selected arguments into possessor, benefactive, attitude holder, ... -
Ages and Stages Questionnaire: a global screening scale | Ages and Stages Questionnaire: una escala de evaluación global
(2017-01-30)Abstract With standardized screening tools, research studies have shown that developmental disabilities can be detected reliably and with validity in children as young as 4 months of age by using the instruments such as ... -
Airway observations during upper endoscopy predicting obstructive sleep apnea
(2016-06-10)Background This pilot study examined airway characteristics during upper endoscopy to determine who is at high risk for obstructive sleep apnea. Methods Patients undergoing routine upper endoscopy were divided into 2 ... -
The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy
(2013-08-24)Hepatocellular carcinoma (HCC) is one of the most common potentially lethal human malignancies worldwide. Advanced or recurrent HCC is frequently resistant to conventional chemotherapeutic agents and radiation. Therefore, ...