Browsing Open Access by Title
Now showing items 219-238 of 866
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Diverse Misfolded Conformational Strains and Cross-seeding of Misfolded Proteins Implicated in Neurodegenerative Diseases
(2019-07-09)Numerous neurodegenerative diseases including prion, Alzheimer’s and Parkinson’s diseases are characterized by accumulation of protein aggregates in brain. Prion disease is unique in that the natively folded prion protein ... -
Diversity in warning coloration: selective paradox or the norm?
(2018-08-27)Aposematic theory has historically predicted that predators should select for warning signals to converge on a single form, as a result of frequency‐dependent learning. However, widespread variation in warning signals is ... -
Diversity of the arctic deep-sea benthos
(2011-02-11)A benthic species inventory of 1,125 taxa was compiled from various sources for the central Arctic deeper than 500 m, and bounded to the Atlantic by Fram Strait. The inventory was dominated by arthropods (366 taxa), ... -
Docosahexaenoic acid counteracts palmitate-induced endoplasmic reticulum stress in C2C12 myotubes: Impact on muscle atrophy
(2017-12)Lipid accumulation in skeletal muscle results in dysregulation of protein meta- bolism and muscle atrophy. We previously reported that treating C2C12 myo- tubes with palmitate (PA), a saturated fatty acid, increases the ... -
Does Land Degradation Increase Poverty in Developing Countries?
(2016-05-11)Land degradation is a global problem that particularly impacts the poor rural inhabitants of low and middle-income countries. We improve upon existing literature by estimating the extent of rural populations in 2000 and ... -
The Dopamine D3 Receptor Knockout Mouse Mimics Aging-Related Changes in Autonomic Function and Cardiac Fibrosis
(2013-08-30)Blood pressure increases with age, and dysfunction of the dopamine D3 receptor has been implicated in the pathogenesis of hypertension. To evaluate the role of the D3 receptor in aging-related hypertension, we assessed ... -
Dose-Dependent Effects of GLD-2 and GLD-1 on Germline Differentiation and Dedifferentiation in the Absence of PUF-8
(2020-01-24)PUMILIO/FBF (PUF) proteins have a conserved function in stem cell regulation. Caenorhabditis elegans PUF-8 protein inhibits the translation of target mRNAs by interacting with PUF binding element (PBE) in the 30 untranslated ... -
A double-blind, randomized, multicenter phase 2 study of prasugrel versus placebo in adult patients with sickle cell disease
(2013-02)Background Platelet activation has been implicated in the pathogenesis of sickle cell disease (SCD) suggesting antiplatelet agents may be therapeutic. To evaluate the safety of prasugrel, a thienopyridine antiplatelet ... -
Driving Decisions: Distinguishing Evaluations, Providers and Outcomes
(2018-05-11)Driving is a highly valued instrumental activity of daily living on which many older adults depend for access to their community. The demand to address driving is changing as older adults experience increasing longevity ... -
Driving innovation through big open linked data (BOLD): Exploring antecedents using interpretive structural modelling
(2016-07-13)Innovation is vital to find new solutions to prob- lems, increase quality, and improve profitability. Big open linked data (BOLD) is a fledgling and rapidly evolving field that creates new opportunities for innovation. ... -
Drosophila Ctf4 is essential for efficient DNA replication and normal cell cycle progression
(2011-04-06)Proper coordination of the functions at the DNA replication fork is vital to the normal functioning of a cell. Specifically the precise coordination of helicase and polymerase activity is crucial for efficient passage ... -
Drug-resistance in doxorubicin-resistant FL5.12 hematopoietic cells: elevated MDR1, drug efflux and side-population positive and decreased BCL2-family member expression
(2017-12-06)Chemotherapeutic drug treatment can result in the emergence of drug-resistant cells. By culturing an interleukin-3 (IL-3)-dependent cell line, FL5.12 cells in the presence of the chemotherapeutic drug doxorubicin, we ... -
Early cell loss associated with mesenchymal stem cell cardiomyoplasty
(2012-03-01)Background: Human mesenchymal stem cells (hMSCs) show potential for therapeutic cellular cardiomyoplasty. However, a range of delivery methods, including direct intramyocardial injection, have resulted in poor engraftment ... -
Early Mobility in the Hospital: Lessons Learned from the STRIDE Program
(2018-09-26)Immobility during hospitalization is widely recognized as a contributor to deconditioning, functional loss, and increased need for institutional post-acute care. Several studies have demonstrated that inpatient walking ... -
The EBM-DPSER Conceptual Model: Integrating Ecosystem Services into the DPSIR Framework
(2013-08)There is a pressing need to integrate biophysical and human dimensions science to better inform holistic ecosystem management supporting the transition from single species or single-sector management to multi-sector ... -
Economic Impact of Early‑in‑Hospital Diagnosis and Initiation of Eculizumab in Atypical Haemolytic Uraemic Syndrome
(2019-12-12)Background Atypical haemolytic uraemic syndrome (aHUS) is a rare, potentially life-threatening condition caused by dysregulation of the complement pathway. Eculizumab is currently the only approved treatment for this ... -
The economic value of rapid deployment aortic valve replacement via full sternotomy
(2017-04-04)Aim: To compare the economic value of EDWARDS INTUITY EliteTM (EIE) valve system for rapid-deployment aortic valve replacement (RDAVR) in a full sternotomy (FS) approach (EIE-FS-RDAVR) versus FS-AVR using conventional ... -
The Effect of Casein Protein Prior to Sleep on Fat Metabolism in Obese Men
(2016-07)We have previously shown that ingesting protein at night before sleep is either beneficial or non-detrimental to metabolism, health, and body composition in obese women. However, the overnight protein-induced lipolytic ... -
Effect of High-Dose Vitamin C Infusion in a Glucose-6-Phosphate Dehydrogenase-Deficient Patient
(2017-11-26)Vitamin C supplementation is generally regarded as benign. There has been a resurgence of interest in the general medical community regarding the use of vitamin C most notably in the care of sepsis. Nonetheless, caution ... -
Effect of Increased Damping in Subordinate Oscillator Arrays
(2018)Previous literature has shown that large structures with a significant number of smaller attached structures exhibit much higher apparent damping than was predicted by models. Further research into this effect led to the ...