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Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
(2013-12-05)
The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection ...
Feasibility of Image-Guided Radiotherapy for Elderly Patients with Locally Advanced Rectal Cancer
(2013-08-13)
Purpose The study aims to assess the tolerance of elderly patients (70 years or older) with locally advanced rectal cancers to image-guided radiotherapy (IGRT). A retrospective review of 13 elderly patients with locally ...
Methods for assessing mitochondrial function in diabetes
(2013-03-14)
A growing body of research is investigating the potential contribution of mitochondrial function to the etiology of type 2 diabetes. Numerous in vitro, in situ, and in vivo methodologies are available to examine various ...
Modeling of non-small cell lung cancer volume changes during CT-based image guided radiotherapy: Patterns observed and clinical implications
(2013-08-26)
Background. To characterize the lung tumor volume response during conventional and hypofractionated radiotherapy (RT) based on diagnostic quality CT images prior to each treatment fraction. Methods. Out of 26 consecutive ...
Promising insights into the health related quality of life for children with severe obesity
(2013-03-01)
Childhood obesity is a growing health concern known to adversely affect quality of life in children and adolescents. The Patient Reported Outcomes Measurement Information System (PROMIS) pediatric measures were developed ...
Racial and ethnic variations in preventive dental care utilization among middle-aged and older Americans, 1999-2008
(2013-09-23)
Objective: This study examined recent trends of preventive dental care utilization among Americans aged 50 and above, focusing on variations across racial and ethnic groups including Whites, Blacks, Hispanics, American ...
Prospective study examining clinical outcomes associated with a negative pressure wound therapy system and Barker's vacuum packing technique
(2013-05-15)
The open abdomen has become a common procedure in the management of complex abdominal problems and has improved patient survival. The method of temporary abdominal closure (TAC) may play a role in patient outcome. A ...
Medical and Household Characteristics Associated with Methicillin Resistant Staphylococcus aureus Nasal Carriage among Patients Admitted to a Rural Tertiary Care Hospital
(2013-08-26)
Methicillin resistant Staphylococcus aureus (MRSA) poses a threat to patient safety and public health. Understanding how MRSA is acquired is important for prevention efforts. This study investigates risk factors for MRSA ...