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Claudin-7 Modulates Cl− and Na+ Homeostasis and WNK4 Expression in Renal Collecting Duct Cells
(2019-07-30)
Claudin-7 knockout (CLDN7−/−) mice display renal salt wasting and dehydration
phenotypes. To address the role of CLDN7 in kidneys, we established collecting duct (CD) cell
lines from CLDN7+/+ and CLDN7−/− mouse kidneys. ...
Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice
(2019-04-05)
α-Klotho, a known anti-aging protein, exerts diverse physiological effects including: maintenance of phosphate and calcium homeostasis, modulation of cell proliferation, and enhanced buffering of reactive oxygen species. ...
Biological significance of RNA-seq and single-cell genomic research in woody plants
(2019-04-01)
RNA-seq and single-cell genomic research emerge as an important research area in the recent years due to its ability to examine genetic information of any number of single cells in all living organisms. The knowledge gained ...
A Blockchain Framework for Patient-Centered Health Records and Exchange (HealthChain): Evaluation and Proof-of-Concept Study
(2019-08-31)
Background: Blockchain has the potential to disrupt the current modes of patient data access, accumulation, contribution, exchange, and control. Using interoperability standards, smart contracts, and cryptographic identities, ...
"I am still negative": Female sex workers' perspectives on uptake and use of daily pre-exposure prophylaxis for HIV prevention in South Africa.
(2019-04)
Women remain highly vulnerable to HIV infection in sub-Saharan Africa, with female sex workers (FSWs) facing some of the highest
rates of HIV. Oral pre-exposure prophylaxis (PrEP) has the potential to reduce new infections ...
Automatic segmentation of cardiac structures for breast cancer radiotherapy
(2019-11-22)
Background and purpose
We developed an automatic method to segment cardiac substructures given a radiotherapy planning CT images to support epidemiological studies or clinical trials looking at cardiac disease endpoints ...
Basic suture technique: Instructional videos explaining suturing for medical students in a qualitative study
(2019-10-25)
Background: Understanding basic surgical skills is important for medical students prior to entering residency regardless of future specialty. In these videos we provide instruction for suturing as it relates to skin closure. ...
“The Ingenious Unravelling of Evidence”: Empathy, Extinction, and Wells’s The Croquet Player
(2019-09-01)
While we are increasingly challenged to imagine a world without humans, we have also become increasingly attentive to the subject of empathy, in popular culture, the humanities, and the sciences. In The Time Machine (1895), ...