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Functional and Comparative Genomics of Hoxa2 Gene cis-Regulatory Elements: Evidence for Evolutionary Modification of Ancestral Core Element Activity
(2016-03-26)
Hoxa2 is an evolutionarily conserved developmental regulatory gene that functions to specify rhombomere (r) and pharyngeal arch (PA) identities throughout the Osteichthyes. Japanese medaka (Oryzias latipes) hoxa2a, like ...
Genome-wide association study identifies multiple susceptibility loci for craniofacial microsomia
(2016-02-08)
Craniofacial microsomia (CFM) is a rare congenital anomaly that involves immature derivatives from the first and second pharyngeal arches. The genetic pathogenesis of CFM is still unclear. Here we interrogate 0.9 million ...
Genetic Architecture of Conspicuous Red Ornaments in Female Threespine Stickleback
(2016-03)
Explaining the presence of conspicuous female ornaments that take the form of male-typical traits has been a longstanding challenge in evolutionary biology. Such female ornaments have been proposed to evolve via both ...
Gene Regulatory Evolution During Speciation in a Songbird
(2016-03-10)
Over the last decade, tremendous progress has been made toward a comparative un- derstanding of gene regulatory evolution. However, we know little about how gene regulation evolves in birds, and how divergent genomes ...
Microvascular Endothelial Dysfunction in Sedentary, Obese Humans Is Mediated by NADPH Oxidase Influence of Exercise Training
(2016)
Objective—The objectives of this study were to determine the impact of in vivo reactive oxygen species (ROS) on
microvascular endothelial function in obese human subjects and the efficacy of an aerobic exercise intervention ...
Hypoxia inducible factor-1α-dependent epithelial to mesenchymal transition under hypoxic conditions in prostate cancer cells
(2016)
Prostate cancer is the most commonly diagnosed
cancer in men and the second leading cause of cancer death.
Hypoxia is an environmental stimulus that plays an important
role in the development and cancer progression ...
Quantitative assessment of image motion blur in diffraction images of moving biological cells
(2016-02)
Motion blur (MB) presents a significant challenge for obtaining high-contrast image data from biological cells with a polarization diffraction imaging flow cytometry (p-DIFC) method. A new p-DIFC experimental system has ...
Response and resilience of Spartina alterniflora to sudden dieback
(2016-08)
We measured an array of biophysical and spectral variables to evaluate the response and recovery of Spartina alterniflora to a sudden dieback event in spring and summer 2004 within a low marsh in coastal Virginia, USA. S. ...