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TLR5 participates in the TLR4 receptor complex and promotes MyD88- dependent signaling in environmental lung injury
(2020-01-28)
Lung disease causes significant morbidity and mortality, and is exacerbated by environmental injury, for example through lipopolysaccharide (LPS) or ozone (O3). Toll-like receptors (TLRs) orchestrate immune responses to ...
Understanding Racial Disparities in Exposure to Traffic-Related Air Pollution: Considering the Spatiotemporal Dynamics of Population Distribution
(2020-02-01)
This study investigates the effect of spatiotemporal distributions of racial groups on
disparities in exposure to traffic-related air pollution by considering people’s daily movement
patterns. Due to human mobility, a ...
The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells
(2020-02-21)
be activated by protons in the inflamed tissue microenvironment. Herein, we report that acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelialcells through the ...
Dose-Dependent Effects of GLD-2 and GLD-1 on Germline Differentiation and Dedifferentiation in the Absence of PUF-8
(2020-01-24)
PUMILIO/FBF (PUF) proteins have a conserved function in stem cell regulation.
Caenorhabditis elegans PUF-8 protein inhibits the translation of target mRNAs by
interacting with PUF binding element (PBE) in the 30 untranslated ...
Characterization of METTL16 as a cytoplasmic RNA binding protein
(2020-01-15)
mRNA modification by N6-methyladenosine (m6A) is involved in many post-transcriptional
regulation processes including mRNA stability, splicing and promotion of translation.
Accordingly, the recently identified mRNA ...
Influence of density and salinity on larval development of salt-adapted and salt-naïve frog populations
(2020-01-08)
Environmental change and habitat fragmentation will affect population densities for many species. For those species that have locally adapted to persist in changed or stressful habitats, it is uncertain how density ...
The lhfpl5 Ohnologs lhfpl5a and lhfpl5b Are Required for Mechanotransduction in Distinct Populations of Sensory Hair Cells in Zebrafish
(2020-01-15)
Hair cells sense and transmit auditory, vestibular, and hydrodynamic information by
converting mechanical stimuli into electrical signals. This process of mechano-electrical
transduction (MET) requires a mechanically ...