Browsing Oncology by Submit Date
Now showing items 21-40 of 41
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Acidosis Activation of the Proton-Sensing GPR4 Receptor Stimulates Vascular Endothelial Cell Inflammatory Responses Revealed by Transcriptome Analysis
(2013)Acidic tissue microenvironment commonly exists in inflammatory diseases, tumors, ischemic organs, sickle cell disease, and many other pathological conditions due to hypoxia, glycolytic cell metabolism and deficient blood ... -
Acidosis Decreases c-Myc Oncogene Expression in Human Lymphoma Cells: A Role for the Proton-Sensing G Protein-Coupled Receptor TDAG8
(2013-10)Acidosis is a biochemical hallmark of the tumor microenvironment. Here, we report that acute acidosis decreases c-Myc oncogene expression in U937 human lymphoma cells. The level of c-Myc transcripts, but not mRNA or protein ... -
Patterns of Pelvic Radiotherapy in Patients with Stage II/III Rectal Cancer
(2013)High-level evidence supports adjuvant radiotherapy for rectal cancer. We examined the influence of sociodemographic factors on patterns of adjuvant radiotherapy for resected Stage II/III rectal cancer. Methods. Patients ... -
Proctitis following stereotactic body radiation therapy for prostate cancer
(2014-12)Background Proctitis after radiation therapy for prostate cancer remains an ongoing clinical challenge and critical quality of life issue. SBRT could minimize rectal toxicity by reducing the volume of rectum receiving ... -
A Tri-Modality Image Fusion Method for Target Delineation of Brain Tumors in Radiotherapy
(2014)Purpose To develop a tri-modality image fusion method for better target delineation in image-guided radiotherapy for patients with brain tumors. Methods A new method of tri-modality image fusion was developed, ... -
Catalpol Modulates Lifespan via DAF-16/FOXO and SKN-1/Nrf2 Activation in
(2015)Catalpol is an effective component of rehmannia root and known to possess various pharmacological properties. The present study was aimed at investigating the potential effects of catalpol on the lifespan and stress tolerance ... -
The Potential Role of Magnetic Resonance Spectroscopy in Image-Guided Radiotherapy
(2014-05)Magnetic resonance spectroscopy (MRS) is a non-invasive technique to detect metabolites within the normal and tumoral tissues. The ability of MRS to diagnose areas of high metabolic activity linked to tumor cell proliferation ... -
Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
(2013-10)The tumor microenvironment is acidic due to glycolytic cancer cell metabolism, hypoxia, and deficient blood perfusion. It is proposed that acidosis in the tumor microenvironment is an important stress factor and selection ... -
Total error shift patterns for daily CT on rails image-guided radiotherapy to the prostate bed
(2011)Background To evaluate the daily total error shift patterns on post-prostatectomy patients undergoing image guided radiotherapy (IGRT) with a diagnostic quality computer tomography (CT) on rails system. Methods A ... -
Automatic quantitative analysis of morphology of apoptotic HL-60 cells
(2014-01)Morphological identification is a widespread procedure to assess the presence of apoptosis by visual inspection of the morphological characteristics or the fluorescence images. The procedure is lengthy and results are ... -
: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification
(2014-09)The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional ... -
A Mathematical Model of Tumor Volume Changes during Radiotherapy
(2013)Purpose. To develop a clinically viable mathematical model that quantitatively predicts tumor volume change during radiotherapy in order to provide treatment response assessment for prognosis, treatment plan optimization, ... -
Yttrium-90 Radioembolization in Patients with Hepatocellular Carcinoma Who have Previously Received Sorafenib
(2013-11)Purpose: Yttrium-90 radioembolization (RE) is a locoregional therapy option for hepatocellular carcinoma (HCC). Sorafenib is a multikinase inhibitor used in HCC that can potentially affect the efficacy of RE by altering ... -
Late gastrointestinal tissue effects after hypofractionated radiation therapy of the pancreas
(2015-09)Background To consolidate literature reports of serious late gastrointestinal toxicities after hypofractionated radiation treatment of pancreatic cancer and attempt to derive normal tissue complication probability (NTCP) ... -
Modeling of Non-Small Cell Lung Cancer Volume Changes during CT-Based Image Guided Radiotherapy: Patterns Observed and Clinical Implications
(2013)Background. To characterize the lung tumor volume response during conventional and hypofractionated radiotherapy (RT) based on diagnostic quality CT images prior to each treatment fraction. Methods. Out of 26 consecutive ... -
Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway
(2011)Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic at inflammatory sites, the mechanisms by which cells respond to acidosis are not well understood. ... -
Radiation isocenter measurement devices and methods and 3-D radiation isocenter visualization systems and related methods
(2008-05-25)A three-dimensional phantom assembly for use with a radiation treatment device includes a three-dimensional support member having at least two, spaced apart opposed surfaces configured to hold at least one generally planar ... -
Method of treatment using chemotherapy and erythropoietin
(1999-07-13)The use of human erythropoietin (EPO) to prevent or treat endothelial injury due to chemotherapy, radiation therapy, mechanical trauma, or to a disease state which damages the endothelium (such as inflammation, heart disease ... -
Prognostic factor from MR spectroscopy in rat with astrocytic tumour during radiation therapy
(2014-11-27)Objective: To investigate the relationship between the tumour volume and metabolic rates of astrocytic tumours using MR spectroscopy (MRS) during radiation therapy (RT). Methods: 12 healthy male Sprague-Dawley® rats ... -
Radioprotective Effect of American Ginseng on Human Lymphocytes at 90 Minutes Post-irradiation: A Study of 40 Cases
(East Carolina University, 2010-05)Backgroundâ Ionizing radiation (IR) initiates intracellular oxidative stress through enhanced formation of reactive oxygen species (ROS) that attack DNA leading to cell death. As the diversity of IR applied in medicine, ...