Browsing by Author "Lu, Qun"
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14-3-3ɛ/ζ Affects the stability of δ-catenin and regulates δ-catenin-induced dendrogenesis
He, Yongfeng; Han, Jeong-Ran; Chang, Ockyoung; Oh, Minsoo; James, Sarah E.; Lu, Qun; Seo, Young-Woo; Kim, Hangun; Kim, Kwonseop (2012-11) -
AGE-DEPENDENT STUDY OF PATHOLOGICAL PROGRESSION OF ALZHEIMER’S DISEASE IN HIPPOCAMPAL AND CORTICAL TISSUE OF HUMAN AND AN AD MOUSE MODEL
Leposa, Taylor A (East Carolina University, 2019-05-02)Degeneration of synaptic plasticity plays a critical role in Alzheimer’s disease (AD) pathogenesis. Recent studies have suggested that neuroinflammation may contribute to this degeneration by disrupting the amyloid metabolism ... -
Anti-Cancer Activity of Cucurbitacin IIa
Boykin, Christi (East Carolina University, 2012)Cancer is a debilitating disease resulting from uncontrolled proliferation. One major treatment strategy for cancer is the application of chemotherapeutic drugs which kill cancer cells. Cucurbitacins are a new family ... -
Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants
James, Sarah E.; Burden, Hubert W.; Burgess, Russell; Xie, Youmei; Tang, Tao; Massa, Stephen M.; Longo, Frank M.; Lu, Qun (East Carolina University, 2008-07)Many chemotherapy drugs are known to cause significant clinical neurotoxicity, which can result in the early cessation of treatment. To identify and develop more effective means of neuroprotection it is important to ... -
The claudin family of proteins in human malignancy: A clinical perspective
Ding, Lei; Lu, Zhe; Lu, Qun; Chen, Yan-Hua (2013-10-07)Tight junctions, or zonula occludens, are the most apical component of the junctional complex and provide one form of cell–cell adhesion in epithelial and endothelial cells. Nearly 90% of malignant tumors are derived from ... -
The claudin family of proteins in human malignancy: a clinical perspective
Ding, Lei; Lu, Zhe; Lu, Qun; Chen, Yan-Hua (2013) -
Claudins in intestines
Lu, Zhe; Ding, Lei; Lu, Qun; Chen, Yan-Hua (2013-07) -
Delta-Catenin Induced Dendritic Morphogenesis: An Essential Role of p190RhoGEF Interaction through Akt1 Mediated Phosphorylation
Kim, Hangun; Han, Jeong-Ran; Park, Jaejun; Oh, Minsoo; James, Sarah E.; Chang, Sunghoe; Lu, Qun; Lee, Kwang Youl; Ki, Hyunkyoung; Song, Woo-Joo; Kwonseop, Kim (East Carolina University, 2008-01-11)delta-Catenin was first identified through its interaction with Presenilin-1 and has been implicated in the regulation of dendrogenesis and cognitive function. However, the molecular mechanisms by which delta-catenin ... -
delta-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles
Zeng, Yan; Abdallah, Agustin; Lu, Jian-Ping; Wang, Tao; Chen, Yan-Hua; Terrian, David M.; Kim, Kwonseop; Lu, Qun (East Carolina University, 2009-03-10)Background: delta-Catenin is a unique member of delta-catenin/armadillo domain superfamily proteins and its primary expression is restricted to the brain. However, delta-catenin is upregulated in human prostatic adenocarcinomas, ... -
E-Cadherin negatively modulates delta-catenin-induced morphological changes and RhoA activity reduction by competing with p190RhoGEF for delta-catenin
Kim, Hangun; Oh, Minsoo; Lu, Qun; Kim, Kwonseop (East Carolina University, 2008-12-12)δ-Catenin is a member of the p120-catenin subfamily of armadillo proteins. Here, we describe distinctive features of δ-catenin localization and its association with E-cadherin in HEK293 epithelial cells. In HEK293 cells ... -
The effects of exercise on hypothalamic neurodegeneration of Alzheimer’s disease mouse model
Do, Khoa; Laing, Brenton Thomas; Landry, Taylor; Bunner, Wyatt; Mersaud, Naderi; Matsubara, Tomoko; Li, Peixin; Yuan, Yuan; Lu, Qun; Huang, Hu (2018-01-02)Alzheimer’s disease is a neurodegenerative disorder that affects the central nervous sys- tem. In this study, we characterized and examined the early metabolic changes in the triple transgenic mouse AD model (3xtg-AD), and ... -
Human homolog of airy and nhancer of plit 1, Hes1, negatively regulates δ-catenin () expression in cooperation with E2F1 in prostate cancer
Lu, Jian-Ping; Zhang, Jiao; Kim, Kwonseop; Case, Thomas C.; Matusik, Robert J.; Chen, Yan-Hua; Wolfe, Michael; Nopparat, Jongdee; Lu, Qun (2010) -
Identification of E2F1 as a positive transcriptional regulator for delta-catenin
Kim, Kwonseop; Oh, Minsoo; Ki, Hyunkyoung; Wang, Tao; Bareiss, Sonja; Fini, M. Elizabeth; Li, Dawei; Lu, Qun (East Carolina University, 2008-05-02)Delta-Catenin is upregulated in human carcinomas. However, little is known about the potential transcriptional factors that regulate delta-catenin expression in cancer. Using a human delta-catenin reporter system, we have ... -
Identification of Extracellular d-Catenin Accumulation for Prostate Cancer Detection
Lu, Qun; Zhang, Jiao; Allison, Ron R.; Gay, Hiram A.; Yang, Wan-Xi; Bhowmick, Neil; Frelix, Gloria; Shapell, Scott; Chen, Yan-Hua (East Carolina University, 2009-03-01)BACKGROUND—Prostate cancer is the second leading cause of cancer death in men, and early detection is essential to reduce mortality and increase survival. δ-Catenin is a unique β-catenin superfamily protein primarily ... -
Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains
Baulac, Stephanie; Lu, Hope; Strahle, Jennifer; Yang, Ting; Goldberg, Matthew S.; Shen, Jie; Schlossmacher; Lemere, Cynthia A.; Lu, Qun; Xia, Weiming (East Carolina University, 2009-02-25)Mutations in the DJ-1 gene have been linked to autosomal recessive familial Parkinson's disease. To understand the function of DJ-1, we determined the DJ-1 expression in both zebrafish and post mortem human brains. We found ... -
Increased nucleotide polymorphic changes in the 5'-untranslated region of δ-catenin (CTNND2) gene in prostate cancer
Wang, Tao; Chen, Yan-Hua; Hong, Heng; Zeng, Yan; Zhang, Jiao; Lu, Jian-Ping; Jeansonne, Beverly; Lu, Qun (East Carolina University, 2009-01)Cancer pathogenesis involves multiple genetic and epigenetic alterations, which result in oncogenic changes in gene expression. δ-Catenin (CTNND2) is overexpressed in cancer although the mechanisms of its upregulation are ... -
Investigating Non-Tight Junction Functions of Claudin-7: Regulating Large Intestine Stem Cell Functions and Niche Maintenance, and Junctional Protein Nanoarchitecture
Naser, Amna (East Carolina University, 2022-12-12)Edit this abstract. -
Method of detecting cancer using delta-catenin
Lu, Qun; Chen, Yan-Hua (2008-11-04)The present invention provides a method for detecting or screening for the presence of cancer in a subject. The method comprises obtaining, providing or collecting a tissue or fluid sample (such as a urine sample) from ... -
A non-tight junction function of claudin-7—Interaction with integrin signaling in suppressing lung cancer cell proliferation and detachment
Lu, Zhe; Kim, Do Hyung; Fan, Junming; Lu, Qun; Verbanac, Kathryn; Ding, Lei; Renegar, Randall; Chen, Yan-Hua (2015-06-17)Background Claudins are a family of tight junction (TJ) membrane proteins involved in a broad spectrum of human diseases including cancer. Claudin-7 is a unique TJ membrane protein in that it has a strong basolateral ... -
Nonreceptor Tyrosine Kinase c-Yes Interacts with Occludin during Tight Junction Formation in Canine Kidney Epithelial Cells
Chen, Yan-Hua; Lu, Qun; Goodenough, Daniel A.; Jeansonne, Beverly (East Carolina University, 2002-04)Occludin is an integral membrane protein that is tyrosine phosphorylated when localized at tight junctions. When Ca2 was depleted from the culture medium, occludin tyrosine phosphorylation was diminished from Madin-Darby ...