Browsing by Issue Date
Now showing items 521-540 of 10629
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Comparative impacts of two major hurricane seasons on the Neuse River and western Pamlico Sound ecosystems
(East Carolina University, 2004-06-22)Ecosystem-level impacts of two hurricane seasons were compared several years after the storms in the largest lagoonal estuary in the U.S., the Albemarle-Pamlico Estuarine System. A segmented linear regression flow model ... -
Methods and devices for delivering exogenously generated speech signals to enhance fluency in persons who stutter
(East Carolina University, 2004-06-22)Methods and devices generate an exogenous natural second speech signal as an auditory stimulus to a user to enhance the fluency of persons who stutter. The natural speech signal is independent of the contemporaneous speech ... -
Base-By-Base: Single nucleotide-level analysis of whole viral genome alignments
(East Carolina University, 2004-07-14)Background: With ever increasing numbers of closely related virus genomes being sequenced, it has become desirable to be able to compare two genomes at a level more detailed than gene content because two strains of an ... -
Ships of Russian America
(2004-08) -
Intact Purine Biosynthesis Pathways Are Required for Wild-Type Virulence of Brucella abortus 2308 in the BALB/c Mouse Model
(East Carolina University, 2004-08)Brucella abortus 2308 derivatives with mini-Tn5 insertions in purE, purL, and purD display significant attenuation in the BALB/c mouse model, while isogenic mutants with mini-Tn5 insertions in pheA, trpB, and dagA display ... -
Ca2+ and Ionic Strength Dependencies of S1-ADP Binding to Actin-Tropomyosin-Troponin: Regulatory Implications
(East Carolina University, 2004-09)Skeletal and cardiac muscle contraction are inhibited by the actin-associated complex of tropomyosin-troponin. Binding of Ca21 to troponin or binding of ATP-free myosin to actin reverses this inhibition. Ca21 and ATP-free ... -
Cloning of somatolactin alpha and beta cDNAs in zebrafish and phylogenetic analysis of two distinct somatolactin subtypes in fish
(2004-09-01)Somatolactin (SL) is a pituitary hormone belonging to the growth hormone/prolactin superfamily, with recognizable homologues in all fish taxa examined to date. Although sequences from most fish share reasonably high sequence ... -
Chemical composite attractant of premolting female blue crabs
(2004-09-02)The present invention provides compositions and methods for attracting premolting female blue crabs to traps for the purpose of obtaining soft shell crabs. -
Comparative genomics of cyclin-dependent kinases suggest co-evolution of the RNAP II C-terminal domain and CTD-directed CDKs
(East Carolina University, 2004-09-20)Background: Cyclin-dependent kinases (CDKs) are a large family of proteins that function in a variety of key regulatory pathways in eukaryotic cells, including control over the cell cycle and gene transcription. Among the ... -
Pseudomonas aeruginosa relA Contributes to Virulence in Drosophila melanogaster
(East Carolina University, 2004-10)The stringent response is a mechanism by which bacteria adapt to nutritional deficiencies through the production of the guanine nucleotides ppGpp and pppGpp, produced by the RelA enzyme. We investigated the role of the ... -
Chowan's Best: Women, Labor, And Change In The Bertie County Herring Industry
(2004-11)The purpose of this thesis is to investigate the role of female labor in the declining herring industry in Bertie County, North Carolina during the later twentieth century. This paper argues that women's changing work ... -
Unique V3 Loop Sequence Derived from the R2 Strain of HIV-Type 1 Elicits Broad Neutralizing Antibodies
(East Carolina University, 2004-11)DNA vaccines expressing the envelope (Env) of the human immunodeficiency virus type 1 (HIV-1) have been relatively ineffective at generating high-titer, long-lasting, neutralizing antibodies. In this study, DNA vaccines ... -
Functional Characterization of a Small Conductance GIRK Channel in Rat Atrial Cells
(East Carolina University, 2004-11)Muscarinic K1 (KACh) channels are key determinants of the inhibitory synaptic transmission in the heart. These channels are heterotetramers consisting of two homologous subunits, G-protein-gated inwardly rectifying K1 ... -
Catabolite repression control (Crc) gene and Pseudomonas virulence
(2004-11-30)The present invention relates to a method of screening for compounds that inhibit the virulence of Pseudomonas bacteria and comprises the steps of: providing a culture medium comprising Pseudomonas bacteria, administering ... -
Composition, formulations & method for prevention & treatment of diseases and conditions associated with bronchoconstriction, allergy(ies) & inflammation
(2004-11-30)A pharmaceutical composition effective for preventing and alleviating bronchoconstriction, lung allergy(ies) and inflammation comprises a surfactant and an oligonucleotide anti-sense to an adenosine receptor gene, flanking ... -
Raf-Induced Vascular Endothelial Growth Factor Augments Kaposi's Sarcoma-Associated Herpesvirus Infection
(East Carolina University, 2004-12)Recombinant green fluorescent protein encoding Kaposi’s sarcoma-associated herpesvirus (rKSHV.152) infection of -estradiol stimulated human foreskin fibroblasts (HFF) or HFF/ B-Raf[FF]:ER (expressing a weaker form of ... -
The delta-14 Mutation of Human Cardiac Troponin T Enhances ATPase Activity and Alters the Cooperative Binding of S1-ADP to Regulated Actin
(East Carolina University, 2004-12-07)The complex of tropomyosin and troponin binds to actin and inhibits activation of myosin ATPase activity and force production of striated muscles at low free Ca2+ concentrations. Ca2+ stimulates ATP activity, and at ... -
Cardiovascular effects in patrol officers are associated with fine particulate matter from brake wear and engine emissions
(East Carolina University, 2004-12-09)Background: Exposure to fine particulate matter air pollutants (PM2.5) affects heart rate variability parameters, and levels of serum proteins associated with inflammation, hemostasis and thrombosis. This study investigated ... -
"...And all the men knew the colors of the sea..." : historical and archaeological investigation of the SS Commodore, Ponce Inlet, Florida
(East Carolina University, 2005)This study focuses on a single question: Are the wreck site remains held under joint title by the Ponce Inlet Lighthouse Association and Norman Serbousek those of the SS Commodore, sunk on January 1, 1897? The answer to ...