Browsing by Author "Brewer, Kori L."
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Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury
Fairbanks, Carolyn A.; Schreiber, Kristin L.; Brewer, Kori L.; Yu, Chen-Guang; Stone, Laura S.; Kitto, Kelley F.; Nguyen, H. Oanh; Grocholski, Brent M.; Shoeman, Don W.; Kehl, Lois J.; Regunathan, Soundararajan; Reis, Donald J.; Yezierski, Robert P.; Wilcox, George L. (East Carolina University, 2000-09-12)Antagonists of glutamate receptors of the N-methyl-D-aspartate subclass (NMDAR) or inhibitors of nitric oxide synthase (NOS) prevent nervous system plasticity. Inflammatory and neuropathic pain rely on plasticity, presenting ... -
Correlation of the National Emergency Medicine M4 Clerkship Examination with USMLE Examination Performance
Lawson, Luan E.; Musick, Davis; Brewer, Kori L. (2015-12)Assessment of medical students’ knowledge in clinical settings is complex yet essential to the learning process. Clinical clerkships use various types of written examinations to objectively test medical knowledge within a ... -
Correlation of the National Emergency Medicine M4 Clerkship Examination with USMLE Examination Performance
Lawson, Luan E.; Musick, Davis; Brewer, Kori L. (2015-12)NTRODUCTION: Assessment of medical students' knowledge in clinical settings is complex yet essential to the learning process. Clinical clerkships use various types of written examinations to objectively test medical ... -
Differential Dopamine D1 and D3 Receptor Modulation and Expression in the Spinal Cord of Two Mouse Models of Restless Legs Syndrome
Meneely, Samantha; Dinkins, Mai-Lynne; Kassai, Miki; Lyu, Shangru; Liu, Yuning; Lin, Chien-Te; Brewer, Kori L.; Li, Yuqing; Clemens, Stefan (2018-09-04)Restless Legs Syndrome (RLS) is often and successfully treated with dopamine receptor agonists that target the inhibitory D3 receptor subtype, however there is no clinical evidence of a D3 receptor dysfunction in RLS ... -
Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord
Brewer, Kori L.; Baran, Christine A.; Whitfield, Brian R.; Jensen, A. Marley; Clemens, Stefan (2014-06)Abstract Dopamine (DA) modulates spinal reflexes, including nociceptive reflexes, in part via the D3 receptor subtype. We have previously shown that mice lacking the functional D3 receptor (D3KO) exhibit decreased paw ... -
Estimation of Laceration Length by Emergency Department Personnel
Bourne, Christina L.; Jenkins, M. Adams; Brewer, Kori L. (2014-11)Introduction Documentation and billing for laceration repair involves a description of wound length. We designed this study to test the hypothesis that emergency department (ED) personnel can accurately estimate wound ... -
Implementing a high sensitivity point-of-care troponin assay is beneficial in an emergency department chest pain population
Evancho, Sarah Elizabeth (East Carolina University, 2017-05-03)Point of care tests (POC) can provide accurate and more rapid results for physicians at the bedside, thus decreasing the patient’s time to treatment and increasing patient prognosis. Cardiac troponin (cTnI) is the leading ... -
Markers for Depression in Post-Myocardial Infarction Murine Model
Thompson, Kayla Marie (East Carolina University, 2017-05-03)Previous research has shown that symptoms of depression are commonly found in patients who suffer from a myocardial infarction (MI). Monoamine transporters such as dopamine, noradrenalin, and serotonin receptors have been ... -
Neuroscience Near-Peer-Led Flipped Classroom Improves Student Confidence With Clinical Application of Content and Test-Taking Skills
Brewer, Kori L.; McAllister, William; Curtis, Caitrin M.; Brown, Andrew; Lim, Szu-Aun (2021) -
PI3K mediated activation of GSK‑3β reduces at‑level primary afferent growth responses associated with excitotoxic spinal cord injury dysesthesias
Bareiss, Sonja; Dugan, Elizabeth; Brewer, Kori L. (2015-06-21)Background Neuropathic pain and sensory abnormalities are a debilitating secondary consequence of spinal cord injury (SCI). Maladaptive structural plasticity is gaining recognition for its role in contributing to the ... -
Predifferentiated Embryonic Stem Cells Prevent Chronic Pain Behaviors and Restore Sensory Function Following Spinal Cord Injury in Mice
Hendricks, Wesley A.; Pak, Elena S.; Owensby, Paul J.; Menta, Kristie J.; Glazova, Margarita; Moretto, Justin; Hollis, Sarah Elizabeth; Brewer, Kori L.; Murashov, Alexander K. (East Carolina University, 2006)Embryonic stem (ES) cells have been investigated in repair of the CNS following neuronal injury and disease; however, the efficacy of these cells in treatment of postinjury pain is far from clear. In this study, we evaluated ... -
SCI-INDUCED MORPHINE TOLERANCE IS ASSOCIATED WITH DOPAMINE PATHWAY EXPRESSION
Patton, Ryan Allen Wilhelm (East Carolina University, 2020-05-04)Opioids are commonly prescribed to relieve neuropathic pain after a spinal cord injury (SCI),4 but often fail to be effective due to an injury-induced state that mimics opioid tolerance.22 Previous studies have shown that ... -
Using Heart Rate Variability to Assess Resident Stress During Central Venous Catheter Simulation
Robbins, Adelaide; March, Juan; Russoniello, Carmen; Robey, Walter; Brewer, Kori L. (2019-04-03)INTRODUCTION: Simulation based central venous catheter (CVC) training has been shown to result in fewer needle passes and complications. Heart rate variability (HRV) has been shown to be effective in identifying stress ...