Browsing by Author "Cascio, Wayne E."
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Acute Adverse Effects of Fine Particulate Air Pollution on Ventricular Repolarization
Liao, Duanping; Shaffer, Michele L.; Rodriguez-Colon, Sol; He, Fan; Li, Xian; Wolbrette, Deborah L.; Yanosky, Jeff D.; Cascio, Wayne E. (2010-07)Background The mechanisms for the relationship between particulate pollution and cardiac disease are not fully understood. Objective We examined the effects and time course of exposure to fine particulate matter ≤ 2.5 ... -
Acute Effects of Fine Particulate Air Pollution on Cardiac Arrhythmia: The APACR Study
He, Fan; Shaffer, Michele L.; Rodriguez-Colon, Sol; Yanosky, Jeff D.; Bixler, Edward O.; Cascio, Wayne E.; Liao, Duanping (2011-03)Background: The mechanisms underlying the relationship between particulate matter (PM) air pollution and cardiac disease are not fully understood. Objectives: We examined the effects and time course of exposure to fine ... -
Acute effects of fine particulate air pollution on ST segment height: A longitudinal study
He, Fan; Shaffer, Michele L.; Rodriguez-Colon, Sol; Bixler, Edward O.; Vgontzas, Alexandros N.; Williams, Ronald W.; Wu, Rongling; Cascio, Wayne E.; Liao, Duanping (2010)Background The mechanisms for the relationship between particulate air pollution and cardiac disease are not fully understood. Air pollution-induced myocardial ischemia is one of the potentially important mechanisms. ... -
Ambient PM Exposure Up-regulates the Expression of Costimulatory Receptors on Circulating Monocytes in Diabetic Individuals
Schneider, Alexandra; Alexis, Neil E.; Diaz-Sanchez, David; Neas, Lucas M.; Harder, Shirley; Herbst, Margaret C.; Cascio, Wayne E.; Buse, John B.; Peters, Annette; Devlin, Robert B. (2011-06)BACKGROUND: Exposure of humans to air pollutants such as ozone and particulate matter (PM) may result in airway and systemic inflammation and altered immune function. One putative mechanism may be through modification of ... -
Association of cardiac and vascular changes with ambient PMin diabetic individuals
Schneider, Alexandra; Neas, Lucas M.; Graff, Donald W.; Herbst, Margaret C.; Cascio, Wayne E.; Schmitt, Mike T.; Buse, John B.; Peters, Annette; Devlin, Robert B. (2010)Background and Objective Exposure to fine airborne particles (PM2.5) has been shown to be responsible for cardiovascular and hematological effects, especially in older people with cardiovascular disease. Some epidemiological ... -
Cardiovascular effects in patrol officers are associated with fine particulate matter from brake wear and engine emissions
Riediker, Michael; Devlin, Robert B.; Griggs, Thomas R.; Herbst, Margaret C.; Bromberg, Philip A.; Williams, Ronald W.; Cascio, Wayne E. (East Carolina University, 2004-12-09)Background: Exposure to fine particulate matter air pollutants (PM2.5) affects heart rate variability parameters, and levels of serum proteins associated with inflammation, hemostasis and thrombosis. This study investigated ... -
Coarse Particulate Matter (PM2.5 - 10) Affects Heart Rate Variability, Blood Lipids, and Circulating Eosinophils in Adults with Asthma
Yeatts, Karin; Svendsen, Erik; Creason, John; Alexis, Neil E.; Herbst, Margaret C.; Scott, James; Kupper, Lawrence; Williams, Ronald W.; Neas, Lucas M.; Cascio, Wayne E.; Devlin, Robert B.; Peden, David B. (East Carolina University, 2007-05)INTRODUCTION: We investigated whether markers of airway and systemic inflammation, as well as heart rate variability (HRV) in asthmatics, change in response to fluctuations in ambient particulate matter (PM) in the coarse ... -
Exploring links between greenspace and sudden unexpected death: A spatial analysis
Wu, Jianyong; Rappazzo, Kristen M.; Simpson, Ross J. Jr; Joodi, Golsa; Pursell, Irion W.; Mounsey, J. Paul; Cascio, Wayne E.; Jackson, Laura E. (2018-02-06)Greenspace has been increasingly recognized as having numerous health benefits. However, its effects are unknown concerning sudden unexpected death (SUD), commonly referred to as sudden cardiac death, which constitutes a ... -
Exposure to Concentrated Coarse Air Pollution Particles Causes Mild Cardiopulmonary Effects in Healthy Young Adults
Graff, Donald W.; Cascio, Wayne E.; Rappold, Ana; Zhou, Haibo; Huang, Yuh-Chin T.; Devlin, Robert B. (East Carolina University, 2009-07)Background: There is ample epidemiologic and toxicologic evidence that exposure to fine particulate matter (PM) air pollution [aerodynamic diameter ≤ 2.5 μm (PM2.5)], which derives primarily from combustion processes, can ... -
Fine Particulate air Pollution is Associated with Higher Vulnerability to Atrial Fibrillation—The APACR Study
Liao, Duanping; Shaffer, Michele L.; He, Fan; Rodriguez-Colon, Sol; Wu, Rongling; Whitsel, Eric A.; Bixler, Edward O.; Cascio, Wayne E. (2011-04)The acute effects and the time course of fine particulate pollution (PM2.5) on atrial fibrillation/flutter (AF) predictors, including P-wave duration, PR interval duration, and P-wave complexity, were investigated in a ... -
Increased Nonconducted P-Wave Arrhythmias after a Single Oil Fly Ash Inhalation Exposure in Hypertensive Rats
Farraj, Aimen K.; Haykal-Coates, Najwa; Winsett, Darrell W.; Hazari, Medhi S.; Carll, Alex P.; Rowan, William H. III; Ledbetter, Allen D.; Cascio, Wayne E.; Costa, Daniel L. (East Carolina University, 2009-05)Background: Exposure to combustion-derived fine particulate matter (PM) is associated with increased cardiovascular morbidity and mortality especially in individuals with cardiovascular disease, including hypertension. PM ... -
Mechanisms controlling the acquisition of a cardiac phenotype by liver stem cells
Muller-Borer, Barbara J.; Cascio, Wayne E.; Esch, Gwyn L.; Kim, Hyung-Suk; Coleman, William B.; Grisham, Joe W.; Anderson, Page A. W.; Malouf, Nadia N. (East Carolina University, 2007-03-06)The mechanisms underlying stem cell acquisition of a cardiac phenotype are unresolved. We studied early events during the acquisition of a cardiac phenotype by a cloned adult liver stem cell line (WB F344) in a cardiac ... -
Peat Bog Wildfire Smoke Exposure in Rural North Carolina Is Associated with Cardiopulmonary Emergency Department Visits Assessed through Syndromic Surveillance
Rappold, Ana G.; Stone, Susan L.; Cascio, Wayne E.; Neas, Lucas M.; Kilaru, Vasu J.; Carraway, Martha Sue; Szykman, James J.; Ising, Amy; Cleve, William E.; Meredith, John T.; Vaughan-Batten, Heather; Deyneka, Lana; Devlin, Robert B. (2011-10)Background: In June 2008, burning peat deposits produced haze and air pollution far in excess of National Ambient Air Quality Standards, encroaching on rural communities of eastern North Carolina. Although the association ... -
Quantum dot labeling of mesenchymal stem cells
Muller-Borer, Barbara J.; Collins, Maria C.; Gunst, Philip R.; Cascio, Wayne E.; Kypson, Alan P. (East Carolina University, 2007-11-07)Background: Mesenchymal stem cells (MSCs) are multipotent cells with the potential to differentiate into bone, cartilage, fat and muscle cells and are being investigated for their utility in cell-based transplantation ...