Browsing Dissertations and Theses by Title
Now showing items 1080-1099 of 4831
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Defining Protein Motions the Comprise the Reaction Barrier in Human Epithelial 15-Lipoxygenase-2
(East Carolina University, 2022-04-27)Proteins are dynamic in nature, with these motions playing a role in substrate binding and product release. Protein thermal motions have emerged as participating in the bond making/breaking steps of catalysis and by extension ... -
DEFINING THE ABILITY OF SNAT NANOTHERAPEUTIC TO INHIBIT SARS-COV-2 INFECTION AND ALTER THE HOST MICRONOME TO INDUCE AN ANTIVIRAL CELLULAR ENVIRONMENT
(East Carolina University, 2023-12-07)MicroRNAs (miRNAs) are regulatory elements that canonically bind to target mRNAs, reducing translation and protein output. They are non-coding strands of RNA, roughly 18-25 nucleotides long, and are found in plants, animals, ... -
Defining the Great Lakes Passenger Freight Propeller: A Statistical, and Historical Study
(East Carolina University, 2018-12-06)Passenger freight propellers were integral to the Great Lakes economy for nearly 100 years. A unique vessel type created for a unique need, shipbuilders combined different new technologies to create faster, more efficient, ... -
Defining the role of acyl-CoA synthetase 6 on α-synucleinopathy
(East Carolina University, 2022-07-19)Background: Neurodegenerative diseases known as α-synucleinopathies, most notably dementias and Parkinson’s Disease (PD), are characterized by neuronal aggregation and accumulation of α-synuclein (α-syn) in a manner that ... -
Defining the role of acyl-CoA synthetase 6 on α-synucleinopathy
(East Carolina University, 2022-07-19)Background: Neurodegenerative diseases known as [alpha]-synucleinopathies, most notably dementias and Parkinson's Disease (PD), are characterized by neuronal aggregation and accumulation of [alpha]-synuclein ([alpha]-syn) ... -
Defining the Role of the C-Terminal Region of Troponin T by Analysis of a Series of Truncation Mutants
(East Carolina University, 2016-07-21)Familial hypertrophic cardiomyopathy and other cardiovascular diseases result from mutations of any of the contractile proteins. Mutations within the actin binding regulatory complex of proteins, including tropomyosin (Tm) ... -
DEFINING THE STRATIGRAPHIC AND PALEOENVIRONMENTAL RECORD OF RAPID SEA-LEVEL RISE DURING THE LATE PLEISTOCENE TO HOLOCENE IN THE ALBEMARLE SOUND REGION OF NORTH CAROLINA
(East Carolina University, 2022-08-19)Sea-level fluctuations throughout the late Quaternary Period are recorded in the shallow stratigraphy and modern geomorphology of coastal North Carolina. In the Albemarle Sound region, four distinct Pleistocene sea-level ... -
DEFINING THE STRATIGRAPHIC AND PALEOENVIRONMENTAL RECORD OF RAPID SEA-LEVEL RISE DURING THE LATE PLEISTOCENE TO HOLOCENE IN THE ALBEMARLE SOUND REGION OF NORTH CAROLINA
(East Carolina University, 2022-08-19)We need to replace the abstract. -
Deletion of LPCAT3 Promotes Enhanced Insulin Signaling in Skeletal Muscle
(East Carolina University, 2015-12-15)Aberrant lipid metabolism has been linked to skeletal muscle insulin resistance. The exact identity of the lipid species that promote skeletal muscle insulin resistance among the human population remains unclear. In this ... -
Delination of Coastal Shark Habitat within North Carolina Waters Using Acoustic Telemetry, Fisher-Independent Surveys, and Local Ecological Knowledge
(East Carolina University, 2016-07-20)Knowledge of shark habitat preferences and use patterns is important to effectively manage shark fisheries and account for interactions between sharks and species targeted by other fishery management or conservation efforts. ... -
DELINEATING THE MECHANISM OF AGGREGATE OR BIOFILM FORMATION IN THE LYME DISEASE SPIROCHETE BORRELIA BURGDORFERI
(East Carolina University, 2021-07-14)Borrelia burgdorferi, the spirochete causing Lyme disease, is transmitted to a vertebrate host by the bite of an infected Ixodes scapularis tick. The spirochete develops antibiotic resistance in humans likely due to the ... -
DELINEATING THE ROLE OF SOLUBLE CD25 AS AN IMMUNOREGULATORY MOLECULE THAT PROMOTES A LOW-ZONE IL-2 SIGNALING ENVIRONMENT FAVORABLE FOR THE SELECTION OF CD25HIGH FOXP3HIGH T CELLS
(East Carolina University, 2021-07-22)Autoimmune diseases develop due to the breakdown of tolerogenic mechanisms that normally maintain immune homeostasis. CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) are critical in the maintenance of tolerance and the ... -
Delineating Wastewater Contaminant Plumes from On-Site Wastewater Treatment Systems in the North Carolina Coastal Plain using Electromagnetic Induction
(East Carolina University, 2016-08-18)In North Carolina, wastewater-derived nutrients and harmful bacteria threaten public health and reduce water quality for many surface water bodies. North Carolina uses ~ 2 million on-site wastewater treatment systems, yet ... -
[Delta]-catenin: implications in prostate cancer progression
(East Carolina University, 2014)Prostate cancer (PCa) is the most commonly diagnosed cancer and the second most common cause of cancer death among men in the US. Due to the advances in research, the ability to detect and cure PCa has improved and led to ... -
A Democratic Art
(East Carolina University, 2013)This is a report on my creative research and it is written in support of my thesis exhibition entitled A Democratic Art. This thesis is an investigation into the ways printmaking is celebrated within the printmaking ... -
Demystifying the Huntress: Exploring the Experiences of Women Hunters in Eastern North Carolina
(East Carolina University, 2017-07-13)The hunter occupies a special place in the system of human-animal interactions. When entering the natural world of wildlife each hunter learns to navigate this world in his or her own way. Hunters aid wildlife management ... -
Dengue risk assessment
(East Carolina University, 2015)Dengue fever is the most prevalent vector borne disease in the world with over 3.6 billion people at risk and one billion new infections (including one million deaths) recorded annually. Risk assessments showing the impact ...