Browsing Dissertations and Theses by Title
Now showing items 2360-2379 of 4831
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Interrelated role of Notch signaling and mTORC pathways in prostate cancer cell survival and growth
(East Carolina University, 2014)Prostate cancer is currently the second highest leading cause of cancer death in men. Notch is a transmembrane receptor protein that is part of a signaling pathway necessary in the normal development of the prostate. ... -
INTERVENTION TO REDUCE SEDENTARY TIME AND IMPROVE CARDIOMETABOLIC RISK FACTORS AMONG SEDENTARY EMPLOYEES
(East Carolina University, 2012)Background: More than half of the US adult population is sedentary and this type of behavior is known to increase an individual's risk for overweight/obesity, hypertension, cardiovascular disease, stroke, type 2 diabetes ... -
An Interview with Yotburd : Creating as a Collector
(East Carolina University, 2015)As an artist I believe it is important to present work in a new way rather than continually looking to traditional methods. The context for the presentation and distribution of art is changing and the collectors of art ... -
Intimate Partner Violence: Satisficing or Maximizing? Examining Indicators of Relationship Commitment
(East Carolina University, 2016-05-03)The negative impacts of intimate partner violence (IPV) have the potential to reach each physical, psychological, social, and spiritual realm of a victim's experience. The motive for women to remain in such violent ... -
The intracellular proteolytic fragment of CD44 alters CD44 function in chondrocytes
(East Carolina University, 2010)CD44 is an adhesion molecule involved in several biological functions and the primary receptor for hyaluronan (HA). In cartilage, CD44 participates in the interplay between cells and the extracellular matrix to fine tune ... -
Intratracheal instillation of silver nanoparticles exacerbates cardiac ischemia/reperfusion injury in male sprague-dawley rats
(East Carolina University, 2014)The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Exposure to particulate matter has been demonstrated to negatively influence cardiovascular health and expand myocardial ... -
INTRINSIC EXERCISE CAPACITY ON HIND LIMB ARTERIAL LIGATION: DIFFERENTIAL IMPACT OF ACTIVE EXERCISE AND ANDROGEN SIGNALING ON POST-ISCHEMIC RECOVERY
(East Carolina University, 2018-12-21)Peripheral arterial disease (PAD) is a common disease that is frequently caused by atherosclerosis and associated thrombosis, leading to a decrease in the blood supply to the lower extremities. PAD has various treatment ... -
Introducing portable pedal machines inside a university library to reduce sedentary behavior
(East Carolina University, 2013)Background: Sedentary behavior is a health risk factor independent of time spent in moderate-to-vigorous physical activity. Sedentary behavior takes place frequently in libraries. Few sedentary behavior interventions ... -
INTRODUCING TRANSLANGUAGING PRACTICES IN AN INTERNATIONAL ELEMENTARY SCHOOL: THE CRITICAL ROLE OF INSTRUCTIONAL ASSISTANTS.
(East Carolina University, 2023-04-21)Language is the vehicle through which we express ourselves and interact with the people and places around us. Language shapes our identity within the varied communities in which we belong. Translanguaging is a concept that ... -
Intron position in RNA polymerase genes and their relationship to eukaryotic phylogenies
(East Carolina University, 2010)Over the past two decades, there has been an increasing amount of research devoted to the study of intron evolution and its relationship to eukaryotic phylogeny. Previous studies have shown that a large percentage of ... -
Intrusion detection using machine learning algorithms
(East Carolina University, 2019-11-27)With the growing rate of cyber-attacks, there is a significant need for intrusion detection systems (IDS) in networked environments. As intrusion tactics become more sophisticated and more challenging to detect, this ... -
Investigating candidate genes for an association with skin color pattern in the mimic poison frog Ranitomeya imitator
(East Carolina University, 8/5/2020)Understanding the genetic basis of adaptive traits can help us better understand their evolution. The mimic poison frog, Ranitomeya imitator, is native to Peru. Like many other species of poison frogs, it has aposematic ... -
Investigating Energy Consumption of Coastal Vacation Rental Homes
(East Carolina University, 2014)In 2007, vacation rental properties in the United States accounted for more than 22% of the domestic lodging market. These properties are a unique segment of the lodging industry due to their residential design and ... -
Investigating Genetic Variants of the Folate One Carbon Metabolism (FOCM) Pathway for Associations with Recurrent Stroke and Measures of Homocysteine
(East Carolina University, 2017-07-17)Stroke is currently the fifth leading cause of death and the leading cause of long-term disability in the United States. Stroke accounts for over 140,000 deaths annually and according to the Centers for Disease Control and ... -
Investigating Intra- and Inter-Molecular Coevolution of Intrinsically Disordered Protein, Prothymosin-alpha
(East Carolina University, 1/13/16)Prothymosin-α (ProTα) is a small, highly acidic protein found in the nuclei of virtually all mammalian tissues. It belongs to a class of proteins known for their lack of a rigid three-dimensional structure called intrinsically ... -
INVESTIGATING MECHANISMS REGULATING MAMMALIAN SPERMATOGONIAL DIFFERENTIATION AND MEIOTIC INITIATION
(East Carolina University, 2022-06-27)Spermatogonia differentiation and meiotic initiation are complex processes essential for male fertility. Despite knowing for nearly 60 years that retinoic acid (RA) is instrumental for successful production of functional ...