Browsing Microbiology and Immunology by Title
Now showing items 121-140 of 268
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Inhibition of histone acetyltransferase (HAT) activity by HBZ extends beyond the p300/CBP HAT family
(2014)We previously reported that HTLV-1 basic leucine zipper factor (HBZ) interacts with the cellular coactivator p300 in cells derived from ATL patients. We further determined that HBZ directly binds to the histone acetyltransferase ... -
Inhibition of Quorum Sensing by a Pseudomonas aeruginosa dksA Homologue
(East Carolina University, 2001-03)The Pseudomonas aeruginosa las (lasR-lasI) and rhl (rhlR-rhlI) quorum-sensing systems regulate the expression of several virulence factors, including elastase and rhamnolipid. P. aeruginosa strain PR1-E4 is a lasR deletion ... -
Initial Characterization of the FlgE Hook High Molecular Weight Complex of
(2014)The spirochete periplasmic flagellum has many unique attributes. One unusual characteristic is the flagellar hook. This structure serves as a universal joint coupling rotation of the membrane-bound motor to the flagellar ... -
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
(East Carolina University, 1994-07)Bacteroides fragilis is an important opportunistic pathogen of humans and is resistant to many drugs commonly used to treat anaerobic infections, including P-lactams. A strain set comprised of B. fragilis isolates producing ... -
Insulin/IGF1-PI3K-dependent nucleolar localization of a glycolytic enzyme – phosphoglycerate mutase 2, is necessary for proper structure of nucleolus and RNA synthesis
(2015-07)Phosphoglycerate mutase (PGAM), a conserved, glycolytic enzyme has been found in nucleoli of cancer cells. Here, we present evidence that accumulation of PGAM in the nucleolus is a universal phenomenon concerning not only ... -
Intact Purine Biosynthesis Pathways Are Required for Wild-Type Virulence of Brucella abortus 2308 in the BALB/c Mouse Model
(East Carolina University, 2004-08)Brucella abortus 2308 derivatives with mini-Tn5 insertions in purE, purL, and purD display significant attenuation in the BALB/c mouse model, while isogenic mutants with mini-Tn5 insertions in pheA, trpB, and dagA display ... -
Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa
(East Carolina University, 2001-09-25)Pseudomonas aeruginosa is an opportunistic pathogen that controls numerous virulence factors through intercellular signals. This bacterium has two quorum-sensing systems (las and rhl), which act through the intercellular ... -
Invasion and Intracellular Survival of Burkholderia cepacia
(East Carolina University, 2000-01)Burkholderia cepacia has emerged as an important pulmonary pathogen in immunocompromised patients and in patients with cystic fibrosis (CF). Little is known about the virulence factors and pathogenesis of B. cepacia, ... -
Investigations into the roles of bacteroides fragilis thioredoxins during the oxidative stress response
(East Carolina University, 2011)The Gram-negative Bacteroides fragilis is the most frequently isolated bacterium from anaerobic infections. Native to the human intestinal tract, it serves a symbiotic role breaking down complex polysaccharides and ... -
Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy
(2011-07)Elucidating the response of breast cancer cells to chemotherapeutic and hormonal based drugs is clearly important as these are frequently used therapeutic approaches. A signaling pathway often involved in chemo- and ... -
The iron response regulator Irr controls iron homoeostasis in Brucella
(East Carolina University, 2014)Members of the genus Brucella are small, Gram-negative intracellular bacterial pathogens that are capable of infecting a wide range of mammalian hosts including humans. Brucella primarily reside inside of host macrophages. ... -
Isolation and characterization of Bordetella bronchiseptica mutants deficient in siderophore activity.
(East Carolina University, 1993-02)Iron acquisition by the gram-negative pathogens Bordetella bronchiseptica and Bordetella pertussis is thought to occur by hydroxamate siderophore-mediated transport as well as an apparently siderophore-independent process ... -
JunD/HBZ enhances HBZ enhances HTLV-1 antisense transcription
(2011)Infection with the human T-cell leukemia virus type 1 (HTLV-1) results in a variety of diseases including adult T-cell leukemia (ATL), a fatal malignancy characterized by the uncontrolled proliferation of virally infected ... -
KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain
(2016-02)Background: Kaposi's sarcoma-associated herpesvirus (KSHV) glycoprotein B (gB) is not only expressed on the envelope of mature virions but also on the surfaces of cells undergoing lytic replication. Among herpesviruses, ... -
Layered regulation of a pathway capable of altering quinolone production in Pseudomonas aeruginosa
(East Carolina University, 2014)Pseudomonas aeruginosa is a gram negative opportunistic pathogen which commonly infects hospitalized patients and those afflicted with cystic fibrosis. P. aeruginosa communicates intercellularly via a system of small ... -
Lyme Disease Pathogenesis
(2021)