Browsing Microbiology and Immunology by Title
Now showing items 125-144 of 268
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Insulin/IGF1-PI3K-dependent nucleolar localization of a glycolytic enzyme – phosphoglycerate mutase 2, is necessary for proper structure of nucleolus and RNA synthesis
(2015-07)Phosphoglycerate mutase (PGAM), a conserved, glycolytic enzyme has been found in nucleoli of cancer cells. Here, we present evidence that accumulation of PGAM in the nucleolus is a universal phenomenon concerning not only ... -
Intact Purine Biosynthesis Pathways Are Required for Wild-Type Virulence of Brucella abortus 2308 in the BALB/c Mouse Model
(East Carolina University, 2004-08)Brucella abortus 2308 derivatives with mini-Tn5 insertions in purE, purL, and purD display significant attenuation in the BALB/c mouse model, while isogenic mutants with mini-Tn5 insertions in pheA, trpB, and dagA display ... -
Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa
(East Carolina University, 2001-09-25)Pseudomonas aeruginosa is an opportunistic pathogen that controls numerous virulence factors through intercellular signals. This bacterium has two quorum-sensing systems (las and rhl), which act through the intercellular ... -
Invasion and Intracellular Survival of Burkholderia cepacia
(East Carolina University, 2000-01)Burkholderia cepacia has emerged as an important pulmonary pathogen in immunocompromised patients and in patients with cystic fibrosis (CF). Little is known about the virulence factors and pathogenesis of B. cepacia, ... -
Investigations into the roles of bacteroides fragilis thioredoxins during the oxidative stress response
(East Carolina University, 2011)The Gram-negative Bacteroides fragilis is the most frequently isolated bacterium from anaerobic infections. Native to the human intestinal tract, it serves a symbiotic role breaking down complex polysaccharides and ... -
Involvement of Akt-1 and mTOR in Sensitivity of Breast Cancer to Targeted Therapy
(2011-07)Elucidating the response of breast cancer cells to chemotherapeutic and hormonal based drugs is clearly important as these are frequently used therapeutic approaches. A signaling pathway often involved in chemo- and ... -
The iron response regulator Irr controls iron homoeostasis in Brucella
(East Carolina University, 2014)Members of the genus Brucella are small, Gram-negative intracellular bacterial pathogens that are capable of infecting a wide range of mammalian hosts including humans. Brucella primarily reside inside of host macrophages. ... -
Isolation and characterization of Bordetella bronchiseptica mutants deficient in siderophore activity.
(East Carolina University, 1993-02)Iron acquisition by the gram-negative pathogens Bordetella bronchiseptica and Bordetella pertussis is thought to occur by hydroxamate siderophore-mediated transport as well as an apparently siderophore-independent process ... -
JunD/HBZ enhances HBZ enhances HTLV-1 antisense transcription
(2011)Infection with the human T-cell leukemia virus type 1 (HTLV-1) results in a variety of diseases including adult T-cell leukemia (ATL), a fatal malignancy characterized by the uncontrolled proliferation of virally infected ... -
KSHV gB associated RGD interactions promote attachment of cells by inhibiting the potential migratory signals induced by the disintegrin-like domain
(2016-02)Background: Kaposi's sarcoma-associated herpesvirus (KSHV) glycoprotein B (gB) is not only expressed on the envelope of mature virions but also on the surfaces of cells undergoing lytic replication. Among herpesviruses, ... -
Layered regulation of a pathway capable of altering quinolone production in Pseudomonas aeruginosa
(East Carolina University, 2014)Pseudomonas aeruginosa is a gram negative opportunistic pathogen which commonly infects hospitalized patients and those afflicted with cystic fibrosis. P. aeruginosa communicates intercellularly via a system of small ... -
Lyme Disease Pathogenesis
(2021) -
Mechanistic analysis of a synthetic inhibitor of the LasI quorum-sensing signal synthase
(2015-11)Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen responsible for many human infections. LasI is an acyl-homoserine lactone synthase that produces a quorum-sensing (QS) signal that positively regulates ... -
MICRONOME AND KSHV INFECTION: IDENTIFICATION AND FUNCTIONAL CHARACTERIZATION OF CELLULAR MICRORNAS DURING VIRUS ENTRY
(East Carolina University, 2018-04-17)Kaposi's sarcoma-associated herpesvirus (KSHV), is the most recently identified human herpesvirus and causes a variety of human malignancies. KSHV is etiologically associated with Kaposi's sarcoma (KS), primary effusion ... -
Molecular and genetic analysis of the Bacteroides uniformis cephalosporinase gene, cblA, encoding the species-specific beta-lactamase.
(East Carolina University, 1994-08)The gene, cbl, encoding the species-specific, clavulanate-susceptible, endogenous cephalosporinase was cloned from Bacteroides uniforinis WAL-7088. The nucleotide sequence was determined, and the cbl structural gene was ...