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Importance of glycosylation on function of a potassium channel in neuroblastoma cells
(2011-04)
The Kv3.1 glycoprotein, a voltage-gated potassium channel, is expressed throughout the central nervous system. The role of N-glycans attached to the Kv3.1 glycoprotein on conducting and non-conducting functions of the Kv3.1 ...
Shoreline change along sheltered coastlines: Insights from the neuse river estuary, NC, USA
(2011-07-12)
Coastlines are constantly changing due to both natural and anthropogenic forces, and climate change and associated sea level rise will continue to reshape coasts in the future. Erosion is not only apparent along oceanfront ...
Remote sensing and modeling of mosquito abundance and habitats in Coastal Virginia, USA
(2011-12-12)
The increase in mosquito populations following extreme weather events poses a major threat to humans because of mosquitoes’ ability to carry disease-causing pathogens, particularly in low-lying, poorly drained coastal ...
Autopsy Standardized Mortality Review: A Pilot Study Offering a Methodology for Improved Patient Outcomes
(2019-02-12)
A standardized mortality review of hospital autopsies identified discrepancies between clinical diagnoses and autopsy findings, unexpected deaths, adequacy of diagnostic workup, presence of adverse event, and type of a ...
Bacteroides fragilis requires the ferrous-iron transporter FeoAB and the CobN-like proteins BtuS1 and BtuS2 for assimilation of iron released from heme
(2018-05-07)
The intestinal commensal and opportunistic anaerobic pathogen Bacteroides fragilis has an essential requirement for both heme and free iron to support growth in extraintestinal infections. In the absence of free iron, B. ...
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: Rationale and importance to inhibiting these pathways in human health
(2011-03-11)
The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Integral components of these pathways, Ras, B-Raf, ...
Efficacy and tolerability of pegloticase for the treatment of chronic gout in patients refractory to conventional treatment: Two randomized controlled trials
(2011-08-17)
Context Patients with chronic disabling gout refractory to conventional urate-lowering therapy need timely treatment to control disease manifestations related to tissue urate crystal deposition. Pegloticase, monomethoxyp ...
Cardiac amyloidosis: A case report and review of literature
(2019-03-26)
BACKGROUND
Cardiac amyloidosis, a disease caused by the precipitation of amyloid proteins in
the myocardial extracellular matrix has been historically difficult to diagnose due
to lack of specific clinical manifestations ...
The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease
(2018-02-26)
The B-cell lymphoma 2–associated anthanogene (BAG3) protein is expressed most prominently in the heart, the skeletal muscle, and in many forms of cancer. In the heart, it serves as a co-chaperone with heat shock proteins ...
Concurrent validity of skin carotenoid status as a concentration biomarker of vegetable and fruit intake compared to multiple 24-h recalls and plasma carotenoid concentrations across one year: a cohort study
(2019-10-30)
Background
Biological markers of vegetable and fruit (VF) intake are needed both for nutrition surveillance and for the evaluation of nutrition interventions. Optically assessed skin carotenoid status (SCS) has been ...