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DNA methylation analyses identify an intronic ZDHHC6 locus associated with time to recurrent stroke in the Vitamin Intervention for Stroke Prevention (VISP) clinical trial
(2021-07-12)
Aberrant DNA methylation profiles have been implicated in numerous cardiovascular diseases; however, few studies have investigated how these epigenetic modifications contribute to stroke recurrence. The aim of this study ...
Interclutch variability in egg characteristics in two species of rail: Is maternal identity encoded in eggshell patterns?
(2022-01-13)
Maternal signatures are present in the eggs of some birds, but quantifying interclutch variability within populations remains challenging. Maternal assignment of eggs with distinctive appearances could be used to non-invasively ...
Social Connectivity During the COVID-19 Pandemic: Disparities among Medicare Beneficiaries
(2021-07-07)
Purpose: Social connections are essential for health and well-being at all ages and may be especially important for promoting health in later life. Maintaining social connections, however, became increasingly ...
Understanding Racial Disparities in Exposure to Traffic-Related Air Pollution: Considering the Spatiotemporal Dynamics of Population Distribution
(2020-02-01)
This study investigates the effect of spatiotemporal distributions of racial groups on
disparities in exposure to traffic-related air pollution by considering people’s daily movement
patterns. Due to human mobility, a ...
TLR5 participates in the TLR4 receptor complex and promotes MyD88- dependent signaling in environmental lung injury
(2020-01-28)
Lung disease causes significant morbidity and mortality, and is exacerbated by environmental injury, for example through lipopolysaccharide (LPS) or ozone (O3). Toll-like receptors (TLRs) orchestrate immune responses to ...
The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells
(2020-02-21)
be activated by protons in the inflamed tissue microenvironment. Herein, we report that acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelialcells through the ...
Dose-Dependent Effects of GLD-2 and GLD-1 on Germline Differentiation and Dedifferentiation in the Absence of PUF-8
(2020-01-24)
PUMILIO/FBF (PUF) proteins have a conserved function in stem cell regulation.
Caenorhabditis elegans PUF-8 protein inhibits the translation of target mRNAs by
interacting with PUF binding element (PBE) in the 30 untranslated ...
Characterization of METTL16 as a cytoplasmic RNA binding protein
(2020-01-15)
mRNA modification by N6-methyladenosine (m6A) is involved in many post-transcriptional
regulation processes including mRNA stability, splicing and promotion of translation.
Accordingly, the recently identified mRNA ...