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Cutaneous adverse reactions in B-RAF positive metastatic melanoma following sequential treatment with B-RAF/MEK inhibitors and immune checkpoint blockade or vice versa. A single-institutional case-series
(2018-12-16)
Background
With the advent of immune-checkpoint inhibitors and targeted treatments (TT), there have been unprecedented response rates and survival in advanced melanoma, but the optimal sequencing of these two treatments ...
A multi-sensor approach to examining the distribution of total suspended matter (TSM) in the Albemarle-Pamlico Estuarine System, NC, USA
(2011)
For many coastal waters, total suspended matter (TSM) plays a major role in key biological, chemical and geological processes. Effective mapping and monitoring technologies for TSM are therefore needed to support research ...
Construction of realistic hybrid computational fetal phantoms from radiological images in three gestational ages for radiation dosimetry applications
(2019-10-10)
Radiation exposure and associated radiation risks are major concerns for fetal development for
pregnant patients who undergo radiation therapy or diagnostic imaging procedures. In order to
accurately estimate the radiation ...
Engaging with Library Staff: Lessons from a Staff Assembly
(2020-06-17)
East Carolina University’s J.Y. Joyner Library provides its employees with the opportunity to have their voice heard and impact the direction of the library by engaging its staff assemblies. The current SHRA Executive ...
The effects of an afterschool STEM program on students’ motivation and engagement
(2017-06-12)
Background: One significant factor in facilitating students’ career intentions and persistence in STEM (science, technology, engineering, and mathematics) fields is targeting their interests and motivation before eighth ...
The moral discourses of ‘post-crisis’ neoliberalism: a case study of Lithuania’s Labour Code reform
(2017-03)
This article problematizes the neoliberal reconfiguration of labour rights in Lithuania, a newer European Union member state, in which the impacts of the global economic and financial crisis were particularly severe and ...
The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
(2017-08-05)
Neonatal rats were administered a relatively high concentration of ethyl alcohol (11.9% v/v) during postnatal days 4-9, a time when the fetal brain undergoes rapid organizational change and is similar to accelerated brain ...
The Madden-Julian Oscillation: A Tool for Regional Seasonal Precipitation Outlooks?
(2017-09-20)
Abstract: The Madden-Julian Oscillation (MJO) is an important intraseasonal climate signal which circles the global tropics, but also impacts extratropical weather regimes. Few studies have investigated whether the MJO is ...
Transcriptional response to West Nile virus infection in the zebra finch (Taeniopygia guttata)
(2017-06)
West Nile virus (WNV) is a widespread arbovirus that imposes a significant cost to both human and wildlife health. WNV exists in a bird-mosquito transmission cycle in which passerine birds act as the primary reservoir host. ...
Trial by Fire: On the Terminology and Methods Used in Pyrogenic Organic Carbon Research
(2017-11-17)
Our understanding of the cycling of fire-derived, i.e., pyrogenic organic matter (pyOM), as well as the goals of the community of researchers who study it, may be inhibited by the many terms and methods currently used in ...