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Healthy CD4+ T lymphocytes are not affected by targeted therapies against the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia
(2016-08-01)
An attractive molecular target for novel anti-cancer therapies is the
phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR)
pathway which is commonly deregulated in many types of cancer. Nevertheless, ...
Digits lost or gained? Evidence for pedal evolution in the Dwarf salamander complex (Eurycea, Plethodontidae)
(2012-05-23)
Change in digit number, particularly digit loss, has occurred repeatedly over the evolutionary history of tetrapods. Although digit loss has been documented among distantly related species of salamanders, it is relatively ...
Effects of aluminum oxide nanoparticles on the growth, development, and microrna expression of tobacco (nicotiana tabacum)
(2012-05-11)
Nanoparticles are a class of newly emerging environmental pollutions. To date, few experiments have been conducted to investigate the effect nanoparticles may have on plant growth and development. It is important to study ...
Early cell loss associated with mesenchymal stem cell cardiomyoplasty
(2012-03-01)
Background: Human mesenchymal stem cells (hMSCs) show potential for therapeutic cellular cardiomyoplasty. However, a range of delivery methods, including direct intramyocardial injection, have resulted in poor engraftment ...
Correlation of pretreatment drug induced apoptosis in ovarian cancer cells with patient survival and clinical response
(2012-08-08)
This study was performed to determine if a chemotherapy-induced apoptosis assay (MiCK) could predict the best therapy for patients with ovarian cancer. A prospective, multi-institutional and blinded trial of the assay was ...
An evolutionary perspective on marine invasions
(2019-12-10)
Species distributions are rapidly changing as human globalization increasingly moves organisms to novel environments. In marine systems, species introductions are the result of a number of anthropogenic mechanisms, notably ...
Predominant Expression of Hybrid N-Glycans Has Distinct Cellular Roles Relative to Complex and Oligomannose N-Glycans
(2016-06)
Glycosylation modulates growth, maintenance, and stress signaling processes.
Consequently, altered N-glycosylation is associated with reduced fitness and disease. Therefore,
expanding our understanding of N-glycans in ...
Probing the Kinetic Anabolism of Poly-Beta-Hydroxybutyrate in Cupriavidus necator H16 Using Single-Cell Raman Spectroscopy
(2016-08)
Poly-beta-hydroxybutyrate (PHB) can be formed in large amounts in Cupriavidus necator and is important for the industrial production of biodegradable plastics. In this investigation, laser tweezers Raman spectroscopy (LTRS) ...
Evolution of plant nucleotide-sugar interconversion enzymes
(2011-11-18)
Nucleotide-diphospho-sugars (NDP-sugars) are the building blocks of diverse polysaccharides and glycoconjugates in all organisms. In plants, 11 families of NDP-sugar interconversion enzymes (NSEs) have been identified, ...