Browsing Physics by Title
Now showing items 21-40 of 49
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In Vivo Blood Glucose Quantification Using Raman Spectroscopy
(2012)We here propose a novel Raman spectroscopy method that permits the noninvasive measurement of blood glucose concentration. To reduce the effects of the strong background signals produced by surrounding tissue and to obtain ... -
An Information-Theoretic Approach to Cellular Decision-Making Strategies: How Rate Distortion Theory Provides an Optimal Method for Describing Binary Cellular Decision-Making Systems
(2014)Rate distortion theory, a branch of information theory, was originally developed to help improve the efficiency of data transmission in telecommunications. It's currently being used as a major modeling method to provide ... -
Interaction cross sections needed for simulation of secondary electron emission spectra from thin metal foils after fast proton impact
(East Carolina University, 2009)Monte Carlo simulations of secondary electron emission from thin metal foils after fast proton impact require reliable interaction cross sections with the target under consideration. Total and energy differential inelastic ... -
Ion Traffic Across Cellular Membranes
(East Carolina University, 2010)The cell membrane protects the delicate internal machinery of the cell and hosts a complex transport system for ion exchange with the environment. Energy is continually expended to maintain a transmembrane electrical ... -
Kinetics of Germination of Individual Spores of as Measured by Raman Spectroscopy and Differential Interference Contrast Microscopy
(2013)Geobacillus stearothermophilus is a gram-positive, thermophilic bacterium, spores of which are very heat resistant. Raman spectroscopy and differential interference contrast microscopy were used to monitor the kinetics of ... -
Label-free classification of cultured cells through diffraction imaging
(2011-05)Automated classification of biological cells according to their 3D morphology is highly desired in a flow cytometer setting. We have investigated this possibility experimentally and numerically using a diffraction imaging ... -
Laser tweezers and Raman spectroscopy systems and methods for the study of microscopic particles
(2005-05-24)Methods and systems for studying microscopic particles are provided. An optical trap for a selected microscopic particle can be formed with a laser beam at a first power level. The laser beam can have a variable power level ... -
Levels of Ca2+-Dipicolinic Acid in Individual Bacillus Spores Determined Using Microfluidic Raman Tweezers
(East Carolina University, 2007-07)Pyridine-2,6-dicarboxylic acid (dipicolinic acid [DPA]) in a 1:1 chelate with calcium ion (Ca-DPA) comprises 5 to 15% of the dry weight of spores of Bacillus species. Ca-DPA is important in spore resistance to many ... -
Mathematical Modeling of Oxygen Transport, Cell Killing and Cell Decision Making in Photodynamic Therapy of Cancer
(East Carolina University, 2012)In this study we present a model of in vitro cell killing through type II Photodynamic Therapy (PDT) for simulation of the molecular interactions leading to cell death in time domain in the presence of oxygen transport ... -
Memory of Germinant Stimuli in Bacterial Spores
(2015-11)Bacterial spores, despite being metabolically dormant, possess the remarkable capacity to detect nutrients and other molecules in their environment through a biochemical sensory apparatus that can trigger spore germination, ... -
MODIFICATION OF CELL SURVIVAL RATES BY CERIUM OXIDE NANOPARTICLES FOR EXPOSURE TO PROTON RADIATION
(East Carolina University, 2017-05-03)Radiation therapy is a well-established and widely used treatment for a variety of malignancies in the human body. Current radiotherapy methods most frequently use x-rays to deliver a lethal dose to tumors with sufficient ... -
Mutation of tandem repeats in fibrin's alpha-C region
(East Carolina University, 2018-01-19)Cardiovascular problems such as myocardial infarctions and emboli are the number one killers in the United States. These health concerns arise from blood clotting unnecessarily in the veins or arteries. Studies have shown ... -
A new assessment model for tumor heterogeneity analysis with [18]F-FDG PET images
(2016-01)It has been shown that the intratumor heterogeneity can be characterized with quantitative analysis of the [18]F-FDG PET image data. The existing models employ multiple parameters for feature extraction which makes it ... -
Optical and dielectric properties of metallic calcium, modeled generalized oscillator strength function of calcium, interaction cross sections of electrons, protons, and alpha particles with calcium
(East Carolina University, 2013)An analysis of the optical and the dielectric properties of calcium, determined from the literature, was performed. The optical functions of calcium were used for a calculation of the energy loss function of calcium. The ... -
Optical Pulling, Optical Deflection, and Optical Trapping of Single Airborne Particles using Negative Photophoresis
(East Carolina University, 2016-05-03)Optical manipulation is the use of light to control the motion of objects. This thesis focuses on the development of optical transportation technology via optical pulling with application to the characterization of single ... -
Optimizing graphene oxide reduction via laser irradiation
(East Carolina University, 2017-01-04)The present report discusses a single step method to reduce graphene oxide via laser irradiation. A computer numerically controlled laser engraver equipped with a 450nm laser diode was engineered to conduct this research. ... -
A PROPOSED METHODOLOGY TO ASSESS HDR [superscript]192Ir RADIAL DOSE WITH FRICKE DOSIMETRY
(East Carolina University, 2011)The radial absorbed dose to water, D(r,theta), a quantity not yet directly measured with primary standards, was assessed with the Fricke solution which has been considered as an absolute aqueous solution to perform dosimetry. ... -
Protection and Sensitization of Human Cells to Proton Radiation by Cerium Oxide Nanoparticles
(East Carolina University, 2017-07-17)In radiation therapy for the treatment of cancer, there is demand for novel approaches that will improve tumor cell killing while protecting healthy tissue. One such approach that has shown considerable promise is the ... -
Quantifying Double-Strand Breaks and Clustered Damages in DNA by Single-Molecule Laser Fluorescence Sizing
(East Carolina University, 2003-02)Fluorescence from a single DNA molecule passing through a laser beam is proportional to the size (contour length) of the molecule, and molecules of different sizes can be counted with equal efficiencies. Single-molecule ... -
Quantitative analysis and comparison of 3D morphology between viable and apoptotic MCF-7 breast cancer cells and characterization of nuclear fragmentation
(2017-09-08)Morphological changes in apoptotic cells provide essential markers for defining and detection of apoptosis as a fundamental mechanism of cell death. Among these changes, the nuclear fragmentation and condensation have ...