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Now showing items 251-260 of 305
Dying in the city of the blues: sickle cell anemia and the politics of race and health
(East Carolina University, 2002-10)
The Biochemical Characterization Of Neuronal K+ Channel N-Glycans And Their Role In Regulating K+ Channel Function
(East Carolina University, 2009)
The Kv3 and Kv1 subfamilies of voltage–gated K+ channels are critical components which contribute to action potential repolarization throughout the central nervous system. Here, it was shown that both absolutely conserved ...
North Carolina's Pediatric Obesity Clinician Reference Guide and Tool Kit
(2009-07-27)
This poster presents the tools developed by clinicians treating childhood obesity in North Carolina. The history of the development of these tools is outlined at the end of the accompanying abstract submission to the ...
Mitochondrial H₂O₂ emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
(2009-03)
High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction and oxidative stress have been ...
Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury
(East Carolina University, 2000-09-12)
Antagonists of glutamate receptors of the N-methyl-D-aspartate subclass (NMDAR) or inhibitors of nitric oxide synthase (NOS) prevent nervous system plasticity. Inflammatory and neuropathic pain rely on plasticity, presenting ...
American Ginseng Modifies 137Cs-Induced DNA Damage and Oxidative Stress in Human Lymphocytes
(East Carolina University, 2009-01-01)
The multifold bioactive medicinal properties of ginseng have been closely linked to its antioxidative ability, which is related to its ginsenoside content. Since the key mechanism of radiation-induced cell death and tissue ...
Some Cardiomyopathy-Causing Troponin I Mutations Stabilize a Functional Intermediate Actin State
(East Carolina University, 2009-03-18)
We examined four cardiomyopathy-causing mutations of troponin I that appear to disturb function by altering the
distribution of thin filament states. The R193H (mouse) troponin I mutant had greater than normal actin-activated ...
Teaching the Art of Medicine: A Changing Portrait in Today's Medical Schools
(2008-03)
Objective: The purpose of the present study was to assess attitudes toward the value of the “art of medicine” in medical education, beliefs regarding whether it can be taught and, if so, the methods of teaching that would ...
Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Protein Interacts with the Cellular Transcription Factor CREB To Inhibit HTLV-1 Transcription
(East Carolina University, 2007-02)
The complex human T-cell leukemia virus type 1 (HTLV-1) retrovirus encodes several proteins that are unique to the virus within its 3 -end region. Among them, the viral transactivator Tax and posttranscriptional regulator ...
Clinical Inquiries: What interventions can help patients stop using chewing tobacco?
(East Carolina University, 2005)
This review article examines current literature to recommend interventions to help patients stop using chewing tobacco.