Browsing Brody School of Medicine by Issue Date
Now showing items 101-120 of 1484
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Characterization of a Peroxide-Resistant Mutant of the Anaerobic Bacterium Bacteroides fragilis
(East Carolina University, 1998-11)A Bacteroides fragilis mutant resistant to hydrogen peroxide and alkyl peroxide was isolated by enrichment in increasing concentrations of hydrogen peroxide. The mutant strain was constitutively resistant to 100 mM H2O2 ... -
Genome scan of human systemic lupus erythematosus: Evidence for linkage on chromosome 1q in African-American pedigrees
(East Carolina University, 1998-12)Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies against intracellular antigens including DNA, ribosomal P, Ro (SS-A), La (SS-B), and the spliceosome. Etiology is ... -
The commodification of human reproductive materials.
(East Carolina University, 1998-12)This essay develops a framework for thinking about the moral basis for the commnodification of human reproductive nmaterials. It argues that selling and buyinlg gametes and genes is morally acceptable although there should ... -
Food Literacy Partners Program: Cooking Class Unit
(1999)The Food Literacy Partners Program is a 20 hour Learn and Serve program that provides 20 hours of food and nutrition education to volunteers in exchange for 20 hours of community nutrition education service. The program ... -
Physical and Functional Interactions between the Herpes Simplex Virus UL15 and UL28 DNA Cleavage and Packaging Proteins
(East Carolina University, 1999-02)Herpes simplex virus (HSV) DNA is cleaved from concatemers and packaged into capsids in infected cell nuclei. This process requires seven viral proteins, including UL15 and UL28. UL15 expressed alone displays a nuclear ... -
Tumour necrosis factor-alpha regulates expression of the CCAAT-enhancer-binding proteins (C/EBPs) alpha and beta and determines the occupation of the C/EBP site in the promoter of the insulin-responsive glucose-transporter gene in 3T3-L1 adipocytes.
(East Carolina University, 1999-03-15)We have demonstrated previously that treatment of 3T3-L1 adipocytes with tumour necrosis factor-alpha (TNF) results in a rapid (4 h) and significant (75–80%) reduction in the rate of transcription of the GLUT4 gene. Control ... -
Multiple target hybridizing nucleic acids, their preparation, compositions, formulation, kits and applications
(1999-03-25)Antisense oligonucleotides which bind to two or more RNA targets are disclosed. -
Method for the microbial decontamination of blood platelets
(1999-04-06)A method for inactivating microbiological contaminants in a human blood platelet preparation is disclosed. The method comprises, first, providing blood platelets, particularly human blood platelets, suspected of being ... -
Surgical aids containing pharmaceutically acceptable fixed-dried human blood platelets
(1999-05-11)Fixed-dried human blood platelets and processes for preparing them are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change ... -
Equitable rationing of highly specialised health care services for children: a perspective from South Africa.
(East Carolina University, 1999-06)The principles of equality and equity, respectively in the Bill of Rights and the white paper on health, provide the moral and legalfoundations forfuture health care for children in South Africa. However, given extreme ... -
Premature mortality in the United States: the roles of geographic area, socioeconomic status, household type, and availability of medical care.
(East Carolina University, 1999-06)OBJECTIVES: This study examined premature mortality by county in the United States and assessed its association with metro/urban/rural geographic location, socioeconomic status, household type, and availability of medical ... -
Method of treatment using chemotherapy and erythropoietin
(1999-07-13)The use of human erythropoietin (EPO) to prevent or treat endothelial injury due to chemotherapy, radiation therapy, mechanical trauma, or to a disease state which damages the endothelium (such as inflammation, heart disease ... -
Defending Diversity: Affirmative Action and Medical Education
(East Carolina University, 1999-08)Affirmative action programs of all types are under attack legally and politically. Although medical schools have not been specifically targeted, their affirmative action programs, like others in higher education, are ... -
Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa
(East Carolina University, 1999-09-28)Numerous species of bacteria use an elegant regulatory mechanism known as quorum sensing to control the expression of specific genes in a cell-density dependent manner. In Gram-negative bacteria, quorum sensing ... -
Essential Role of the Iron-Regulated Outer Membrane Receptor FauA in Alcaligin Siderophore-Mediated Iron Uptake in Bordetella Species
(East Carolina University, 1999-10)Phenotypic analysis using heterologous host systems localized putative Bordetella pertussis ferric alcaligin transport genes and Fur-binding sequences to a 3.8-kb genetic region downstream from the alcR regulator gene. ... -
Pharmaceutically acceptable fixed-dried human blood platelets
(1999-11-30)Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution; adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change ... -
Low adenosine agent, composition, kit and method for treatment of airway disease
(1999-11-30)An oligonucleotide which is antisense to a mRNA encoding a polypeptide involved in airway disease(s) contains up to three adenosines per every 21 nucleotide a method of treating airway disease in a subject in need of such ... -
Calponin interaction with alpha-actinin-actin: evidence for a structural role for calponin.
(East Carolina University, 1999-12)The purpose of this study was to address the paradox of calponin localization with a-actinin and filamin, two proteins with tandem calponin homology (CH) domains, by determining the effect of these proteins on the binding ... -
Systematic review of diagnostic tests for vaginal trichomoniasis.
(East Carolina University, 2000)Objective: To review critically and to summarize the evidence of diagnostic tests and culture media for the diagnosis of Trichomonas vaginitis. Methods: We performed a systematic review of literature indexed in MEDLINE of ... -
The Global Carbon Metabolism Regulator Crc Is a Component of a Signal Transduction Pathway Required for Biofilm Development by Pseudomonas aeruginosa
(East Carolina University, 2000-01)The transition from a planktonic (free-swimming) existence to growth attached to a surface in a biofilm occurs in response to environmental factors, including the availability of nutrients. We show that the catabolite ...