Browsing Brody School of Medicine by Title
Now showing items 1167-1186 of 1484
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Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Cascade Inhibitors: How Mutations Can Result in Therapy Resistance and How to Overcome Resistance
(2012-10)The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Integral components of these pathways, Ras, B-Raf, ... -
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
(2011-03)The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Integral components of these pathways, Ras, B-Raf, ... -
Rat-bite fever as a cause of septic arthritis: a diagnostic dilemma.
(East Carolina University, 1987-10)Rat-bite fever results from an infection with the organism Streptobacillus moniliformis. Symptomatic patients often present with fever, malaise, cough, maculopapular rash, and occasional arthritis, and usually have a history ... -
Raw beef liver could mean trip to hospital
(2022-08-31)This is a weekly Q and A newspaper column under the byline of Dr. Kathy Kolasa. Today's column involves the medical risks associated with human consumption of raw beef liver. -
Reaction to Milk Requires Accurate Diagnosis, Proper Management
(2023-04-26)This is a weekly Q and A newspaper column under the byline of Dr. Kathy Kolasa. Today's column is about the differences between signs/symptoms and treatment of lactose intolerance and cow's milk protein allergy. -
Real meat grown in the lab could be on the table soon
(2022-05-11)This is a weekly Q and A newspaper column under the byline of Dr. Kathy Kolasa. Today's column is a discussion about cell cultured proteins. -
RecA and RadA Proteins of Brucella abortus Do Not Perform Overlapping Protective DNA Repair Functions following Oxidative Burst
(East Carolina University, 2006-07)Very little is known about the role of DNA repair networks in Brucella abortus and its role in pathogenesis. We investigated the roles of RecA protein, DNA repair, and SOS regulation in B. abortus. While recA mutants in ... -
Recent discoveries in the cycling, growing and aging of the p53 field
(2012-12)The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on the topic of p53 has been abstracted in Pubmed. ... -
Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes
(2012-12)It is widely believed that aging results from the accumulation of molecular damage, including damage of DNA and mitochondria and accumulation of molecular garbage both inside and outside of the cell. Recently, this paradigm ... -
Recent progress in targeting cancer
(2011-12)In recent years, numerous new targets have been identified and new experimental therapeutics have been developed. Importantly, existing non-cancer drugs found novel use in cancer therapy. And even more importantly, new ... -
Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment
(2015-12)Veterans of Operation Desert Storm/Desert Shield - the 1991 Gulf War (GW) - are a unique population who returned from theater with multiple health complaints and disorders. Studies in the U.S. and elsewhere have consistently ... -
Recommendations for active correction of hypernatremia in volume-resuscitated shock or sepsis patients should be taken with a grain of salt: A systematic review
(2018-03-21)Background: Healthcare-acquired hypernatremia (serum sodium >145 mEq/dL) is common among critically ill and other hospitalized patients and is usually treated with hypotonic fluid and/or diuretics to correct a “free water ... -
The Redox-Sensitive Transcriptional Activator OxyR Regulates the Peroxide Response Regulon in the Obligate Anaerobe Bacteroides fragilis
(East Carolina University, 2000-09)The peroxide response-inducible genes ahpCF, dps, and katB in the obligate anaerobe Bacteroides fragilis are controlled by the redox-sensitive transcriptional activator OxyR. This is the first functional oxidative ...