Browsing Brody School of Medicine by Title
Now showing items 641-660 of 1484
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Human antibodies for immunotherapy development generated via a human B cell hybridoma technology
(East Carolina University, 2006-03-07)Current strategies for the production of therapeutic mAbs include the use of mammalian cell systems to recombinantly produce Abs derived from mice bearing human Ig transgenes, humanization of rodent Abs, or phage ... -
HUMAN RNA METHYLTRANSFERASE METTL16 AFFECTS MULTIPLE CELL PROCESSES THROUGH DIFFERENTIAL FUNCTION OF ITS DOMAINS
(East Carolina University, 2022-11-10)ABSTRACT In recent years, disease therapies have been developed to target specific RNA and protein expression changes in the affected cells/tissue. The RNA post-transcriptional modification, methyl-6-adenosine (m6A), has ... -
Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Protein Interacts with the Cellular Transcription Factor CREB To Inhibit HTLV-1 Transcription
(East Carolina University, 2007-02)The complex human T-cell leukemia virus type 1 (HTLV-1) retrovirus encodes several proteins that are unique to the virus within its 3 -end region. Among them, the viral transactivator Tax and posttranscriptional regulator ... -
Human T-cell Leukemia Virus Type 1 Basic Leucine Zipper Factor (HBZ) Interacts and Inhibits the Acetyltransferase Activity of Multiple Cellular Coactivator Families to Deregulate Transcription
(East Carolina University, 1/13/16)Of the 20 million individuals infected worldwide with the complex retrovirus, Human T-cell Leukemia Virus Type 1, 5% will develop an incurable and fatal form of leukemia known as adult T-cell leukemia (ATL). During the ... -
Human T-Cell Leukemia Virus Type I Basic Leucine Zipper Factor (HBZ) Modulates Cellular DNA Damage Repair and Antioxidant Responses to Promote Host Cell Survival and Leukemogenesis
(East Carolina University, 2018-04-19)Approximately twenty million people worldwide are infected with Human T-cell Leukemia Virus type 1 (HTLV-1). HTLV-1 establishes a life-long, chronic infection which can result in the development of severe HTLV-1 associated ... -
HuR binds to a single site on the C/EBP - beta mRNA of 3T3-L1 Adipocytes
(East Carolina University, 2007-03-30)HuR is a ligand for nuclear mRNAs containing adenylate-uridylate rich elements in the 3'- untranslated region. Once bound to the mRNA, HuR is recognized by adapter proteins which then facilitate nuclear export of the ... -
HuR involvement in mitotic clonal expansion during acquisition of the adipocyte phenotype
(East Carolina University, 2009-05-29)In the nucleus HuR binds to mRNAs containing adenylate-uridylate rich elements in the 3?- untranslated region. HuR may influence expression of its ligand mRNA through regulation of polyadenylation, translocation of the ... -
Hyaluronan Oligosaccharides Inhibit Tumorigenicity of Osteosarcoma Cell Lines MG-63 and LM-8 in Vitro and in Vivo via Perturbation of Hyaluronan-Rich Pericellular Matrix of the Cells
(East Carolina University, 2007-07)Numerous studies have demonstrated a correlation between hyaluronan expression and the malignant properties of various kinds of cancer , and inhibition of hyaluronan production causes decreased tumor growth. Hyaluronan ... -
Hypothermia in trauma patients: predicting the big chill
(2012)Physicians commonly ignore hypothermia, an often-underappreciated event associated with mortality in trauma patients, in general due to its prevalence and belief that it is secondary to the injury itself (secondary ... -
Hypothesis for induction and propagation of chemical sensitivity based on biopsy studies.
(East Carolina University, 1997-03)The reactive airways dysfunction syndrome (RADS), the reactive upper airways dysfunction syndrome (RUDS), the sick building syndrome (SBS), and the multiple chemical sensitivity syndrome (MCS) are overlapping disorders ... -
Hypoxic Conditioned Medium from Rat Cerebral Cortical Cells Enhances the Proliferation and Differentiation of Neural Stem Cells Mainly through PI3-K/Akt Pathways
(2014)Purpose To investigate the effects of hypoxic conditioned media from rat cerebral cortical cells on the proliferation and differentiation of neural stem cells (NSCs) in vitro, and to study the roles of PI3-K/Akt and JNK ... -
I want to survive and thrive: diet and physical activity recommendations for Breast Cancer Survivors
(2018-09)In this article, we review current diet and physical activity recommendations for long-time survivors of breast cancer. We also hear the voice of a survivor and her response to the diagnosis of a postmenopausal breast ... -
Identification and Characterization of alcR, a Gene Encoding an AraC-Like Regulator of Alcaligin Siderophore Biosynthesis and Transport in Bordetella pertussis and Bordetella bronchiseptica
(East Carolina University, 1998-02)A Bordetella bronchiseptica iron transport mutant was isolated following an enrichment procedure based on streptonigrin resistance. The mutant displayed a growth defect on iron-restricted medium containing ferric alcaligin ... -
Identification and characterization of iron-regulated Bordetella pertussis alcaligin siderophore biosynthesis genes.
(East Carolina University, 1996-08)Bordetella bronchiseptica mutants BRM1, BRM6, and BRM9 fail to produce the native dihydroxamate siderophore alcaligin. A 4.5-kb BamHI-SmaI Bordetella pertussis genomic DNA fragment carried multiple genes required to restore ... -
Identification and Characterization of Optimal Gene Expression Markers for Detection of Breast Cancer Metastasis
(East Carolina University, 2005-08)Sentinel lymph node (SLN) status is highly predictive of overall axillary lymph node involvement in breast cancer. Historically, SLN-positive patients have undergone axillary lymph node dissection in a second ... -
Identification of a circular intermediate in the transfer and transposition of Tn4555, a mobilizable transposon from Bacteroides spp.
(East Carolina University, 1993-05)Transmissible cefoxitin (FX) resistance in Bacteroides vulgatus CLA341 was associated with the 12.5-kb, mobilizable transposon, Tn4555, which encoded the 13-lactamase gene cfxA. Transfer occurred by a conjugation-like ...