Browsing Brody School of Medicine by Title
Now showing items 878-897 of 1484
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MicroRNA-431 regulates axon regeneration in mature sensory neurons by targeting the Wnt antagonist
(2013-10)MicroRNAs (miRNAs) are small, non-coding RNAs that function as key post-transcriptional regulators in neural development, brain function, and neurological diseases. Growing evidence indicates that miRNAs are also important ... -
the MIND diet handout
(2020-11-01)The 2 page handout was designed to help patients/clients visualize an eating approach emphasizing food found in reducing dementia risk and slowing cognitive decline. It is based on the book, "Diet for the Mind" by Martha ... -
A Minimally-Invasive Procedure for Sexing Young Zebra Finches
(East Carolina University, 2007-08-15)Zebra finches have been widely used to study neurobiology underlying vocal development. Because only male zebra finches learn song, efficient developmental use of these animals requires early determination of sex at ages ... -
Mitochondrial H₂O₂ emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
(2009-03)High dietary fat intake leads to insulin resistance in skeletal muscle, and this represents a major risk factor for type 2 diabetes and cardiovascular disease. Mitochondrial dysfunction and oxidative stress have been ... -
Mitochondrial Respiratory Capacity and Content Are Normal in Young Insulin-Resistant Obese Humans
(2014-01)Considerable debate exists about whether alterations in mitochondrial respiratory capacity and/or content play a causal role in the development of insulin resistance during obesity. The current study was undertaken to ... -
: A Model System for Anti-Cancer Drug Discovery and Therapeutic Target Identification
(2014-09)The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional ... -
Modeling of Non-Small Cell Lung Cancer Volume Changes during CT-Based Image Guided Radiotherapy: Patterns Observed and Clinical Implications
(2013)Background. To characterize the lung tumor volume response during conventional and hypofractionated radiotherapy (RT) based on diagnostic quality CT images prior to each treatment fraction. Methods. Out of 26 consecutive ... -
Moderation is key when adding alcohol into a healthy diet
(2023-01-17)This is a weekly Q and A newspaper column under the byline of Dr. Kathy Kolasa. Today's column is focused on the effects of alcohol on your body and brain, and describes the current literature regarding the safety and ... -
Modulation of experimental autoimmune myocarditis with cytokine-myosin fusion proteins and novel cardiac peptides
(2016-05-16)Infectious agents that induce cross-reactive myocarditic T cell responses may cause autoimmune inflammation of the heart, dilated cardiomyopathy (DCM), and heart failure. The purpose of this study was to evaluate the ... -
Molecular and genetic analysis of the Bacteroides uniformis cephalosporinase gene, cblA, encoding the species-specific beta-lactamase.
(East Carolina University, 1994-08)The gene, cbl, encoding the species-specific, clavulanate-susceptible, endogenous cephalosporinase was cloned from Bacteroides uniforinis WAL-7088. The nucleotide sequence was determined, and the cbl structural gene was ... -
Molecular basis for the immunosuppressive action of stearic acid on T cells.
(East Carolina University, 1990-07)Studies were performed to determine the mechanism by which stearic acid (18: 0) selectively inhibits T-dependent immune responses in vitro. Incubation of mitogen-activated B and T cells with 18:0 resulted in dissimilar ... -
Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment
(2015-05)Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the “Warburg effect”, commonly ... -
Molecular Histology of EphrinA1 Expression in Mouse Heart Visualized Molecular Histology of EphrinA1 Expression in Mouse Heart Visualized with MALDI-MSI
(East Carolina University, 2018-07-25)EphrinA1 is a tyrosine kinase receptor localized in the cellular membrane of healthy cardiomyocytes, the expression of which is lost upon myocardial infarction (MI). Intra-cardiac injection of the recombinant form of ... -
Molecular mechanism of anandamide-induced apoptosis in non-melanoma skin cancer.
(East Carolina University, 2015)Non-melanoma skin cancer (NMSC) is the most common cancer in the United States. The absence of selective toxicity is the major problem associated with chemotherapeutic and radiation therapy for NMSCs. The goal of the present ... -
MOLECULAR MECHANISM OF ELLAGIC ACID AND UROLITHIN A IN THE SUPPRESSION OF PROSTATE CANCER BY INFLUENCING THE p53-MDM2 PATHWAY
(East Carolina University, 2019-07-10)Carcinoma of the prostate (CaP) is the most common cancer in men and the second leading cause of cancer-related death in men worldwide. Despite the available treatments for CaP including surgery and Androgen deprivation ...