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Identification of E2F1 as a positive transcriptional regulator for delta-catenin
(East Carolina University, 2008-05-02)
Delta-Catenin is upregulated in human carcinomas. However, little is known about the potential transcriptional factors that regulate delta-catenin expression in cancer. Using a human delta-catenin reporter system, we have ...
Small Molecule, Non-Peptide p75NTR Ligands Inhibit Aß-Induced Neurodegeneration and Synaptic Impairment
(East Carolina University, 2008-11-03)
The p75 neurotrophin receptor (p75NTR) is expressed by neurons particularly vulnerable in Alzheimer’s disease (AD). We tested
the hypothesis that non-peptide, small molecule p75NTR ligands found to promote survival signaling ...
Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains
(East Carolina University, 2009-02-25)
Mutations in the DJ-1 gene have been linked to autosomal recessive familial Parkinson's disease. To understand the function of DJ-1, we determined the DJ-1 expression in both zebrafish and post mortem human brains. We found ...
delta-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles
(East Carolina University, 2009-03-10)
Background: delta-Catenin is a unique member of delta-catenin/armadillo domain superfamily proteins and its primary expression is restricted to the brain. However, delta-catenin is upregulated in human prostatic adenocarcinomas, ...
Identification of Extracellular d-Catenin Accumulation for Prostate Cancer Detection
(East Carolina University, 2009-03-01)
BACKGROUND—Prostate cancer is the second leading cause of cancer death in men, and early
detection is essential to reduce mortality and increase survival. δ-Catenin is a unique β-catenin
superfamily protein primarily ...
E-Cadherin negatively modulates delta-catenin-induced morphological changes and RhoA activity reduction by competing with p190RhoGEF for delta-catenin
(East Carolina University, 2008-12-12)
δ-Catenin is a member of the p120-catenin subfamily of armadillo proteins. Here, we describe
distinctive features of δ-catenin localization and its association with E-cadherin in HEK293 epithelial
cells. In HEK293 cells ...
Nonreceptor Tyrosine Kinase c-Yes Interacts with Occludin during Tight Junction Formation in Canine Kidney Epithelial Cells
(East Carolina University, 2002-04)
Occludin is an integral membrane protein that is tyrosine phosphorylated when localized at tight junctions. When Ca2 was depleted from the culture medium, occludin tyrosine phosphorylation was diminished from Madin-Darby ...
Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants
(East Carolina University, 2008-07)
Many chemotherapy drugs are known to cause significant clinical neurotoxicity, which can result in the early cessation of treatment. To identify and develop more effective means of neuroprotection it is important to ...
Delta-Catenin Induced Dendritic Morphogenesis: An Essential Role of p190RhoGEF Interaction through Akt1 Mediated Phosphorylation
(East Carolina University, 2008-01-11)
delta-Catenin was first identified through its interaction with Presenilin-1 and has been implicated in the regulation of dendrogenesis and cognitive function. However, the molecular mechanisms by which delta-catenin ...
Increased nucleotide polymorphic changes in the 5'-untranslated region of δ-catenin (CTNND2) gene in prostate cancer
(East Carolina University, 2009-01)
Cancer pathogenesis involves multiple genetic and epigenetic alterations, which result in oncogenic changes in gene expression. δ-Catenin (CTNND2) is overexpressed in cancer although the mechanisms of its upregulation are ...