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The intracellular proteolytic fragment of CD44 alters CD44 function in chondrocytes
(East Carolina University, 2010)
CD44 is an adhesion molecule involved in several biological functions and the primary receptor for hyaluronan (HA). In cartilage, CD44 participates in the interplay between cells and the extracellular matrix to fine tune ...
Vanadium pentoxide induces pulmonary inflammation and tumor promotion in a strain-dependent manner
(2010)
Background
Elevated levels of air pollution are associated with increased risk of lung cancer. Particulate matter (PM) contains transition metals that may potentiate neoplastic development through the induction of ...
Sinusoidal Cox Regression—A Rare Cancer Example
(2010-11)
Evidence of an association between survival time and date of birth would suggest an etiologic role for a seasonally variable environmental exposure occurring within a narrow perinatal time period. Risk factors that may ...
On-Line Adaptive Radiation Therapy: Feasibility and Clinical Study
(2010)
The purpose of this paper is to evaluate the feasibility and clinical dosimetric benefit of an on-line, that is, with the patient in the treatment position, Adaptive Radiation Therapy (ART) system for prostate cancer ...
Commute Times, Food Retail Gaps, and Body Mass Index in North Carolina Counties
(2010-09)
Introduction
The prevalence of obesity is higher in rural than in urban areas of the United States, for reasons that are not well understood. We examined correlations between percentage of rural residents, commute times, ...
Breaking Patterns of Environmentally Influenced Disease for Health Risk Reduction: Immune Perspectives
(2010-08)
Diseases rarely, if ever, occur in isolation. Instead, most represent part of a more complex web or “pattern” of conditions that are connected via underlying biological mechanisms and processes, emerge across a lifetime, ...
Environmental risk factors for autism
(2010-04)
Autism is a devastating childhood condition that has emerged as an increasing social concern just as it has increased in prevalence in recent decades. Autism and the broader category of autism spectrum disorders are among ...
Nocturnal thoracoabdominal asynchrony in house dust mite-sensitive nonhuman primates
(2010)
Nocturnal bronchoconstriction is a common symptom of asthma in humans, but is poorly documented in animal models. Thoracoabdominal asynchrony (TAA) is a noninvasive clinical indication of airway obstruction. In this study, ...
Take Off 4-Health: Innovative Strategies to Improve Wellness in Adolescents
(2010-11-09)
Summer camps for weight loss are popular. We present the nutrition curriculum for a 3 week residential camp for adolescents with health risks related to obesity or type 2 diabetes. The curriculum includes a camper meal ...
Tissue Salvage in the Non-reperfused Myocardium Mediated by (the absence of the circadian rhythm gene) mPer2 and (the receptor tyrosine kinase) EphrinA1
(East Carolina University, 2010)
Alterations in circadian rhythm have been associated with numerous cardiovascular pathologies. In project 1, we tested the hypothesis that functional mutation of the Per2 circadian clock gene would provide cardioprotection ...