Browsing Anatomy and Cell Biology by Title
Now showing items 10-29 of 66
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Claudins in intestines
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CRISPR/Cas9 knockout of HAS2 in rat chondrosarcoma chondrocytes demonstrates the requirement of hyaluronan for aggrecan retention
(East Carolina University, 2016-12-15)Hyaluronan (HA) plays an essential role in cartilage where it functions to retain aggrecan. Previous studies suggested that aggrecan is anchored indirectly to the plasma membrane of chondrocytes via its binding to ... -
[Delta]-catenin: implications in prostate cancer progression
(East Carolina University, 2014)Prostate cancer (PCa) is the most commonly diagnosed cancer and the second most common cause of cancer death among men in the US. Due to the advances in research, the ability to detect and cure PCa has improved and led to ... -
Discovering mechanisms during spermatogonial differentiation that prepare male germ cells for meiosis
(East Carolina University, 2022-12-05)Spermatogenesis, the male germ cell maturation process, allows men to become and remain fertile for decades. Male fertility relies on fate decisions of different types of spermatogonia – spermatogonial stem cells maintain ... -
Do Pesticides cause Obesity and Diabetes?
(2019-08-05)We have an epidemic of obesity that presents with serious health and economic consequences. Obesity is the most common disease in the U.S. that has developed rapidly in only a matter of decades. Glyphosate (RoundupTM) ... -
The effect of brevenal on brevetoxin-induced DNA damage in human lymphocytes
(East Carolina University, 2005-11)Brevenal is a nontoxic short-chain trans-syn polyether that competes with brevetoxin (PbTx) for the active site on voltage-sensitive sodium channels. The PbTxs are highly potent polyether toxins produced during blooms of ... -
Effect of testosterone replacement or duration of castration on baroreflex bradycardia in conscious rats
(East Carolina University, 2005-03-30)Background: In this study, we tested the hypothesis that 17β-estradiol contributes to testosterone-mediated restoration of baroreflex-mediated bradycardia in short-term (3 weeks) castrated rats. Further, a reported increase ... -
Estrogen-dependent enhancement of NO production in the nucleus tractus solitarius contributes to ethanol-induced hypotension in conscious female rats
(East Carolina University, 2009-02)Background- Our previous pharmacological and cellular studies showed that peripheral (cardiac and vascular) NOS-derived NO is implicated in the estrogen-dependent hypotensive action of ethanol in female rats. The objective ... -
Evidence for the presence of A1 adenosine receptors in the aorta of spontaneously hypertensive rats
(East Carolina University, 2001-12)1 Isolated aortic rings (endothelium-intact and -denuded) from spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats were used in this study to examine the vasoactive e ects of various adenosine analogues. 2 In ... -
Extracellular matrix induction method to produce pancreatic islet tissue
(1990-06-19)A method and composition of regenerating tissue. More specifically, a method for regenerating pancreatic islet tissue having the histological and insulin-containing properties of islets typically found in neonatal or adult ... -
The extracellular processing of aggrecan aggregate and its effect on CD44 mediated internalization of hyaluronan.
(East Carolina University, 2015)In many cells the hyaluronan receptor CD44 mediates the endocytosis of hyaluronan and its delivery to endosomes / lysosomes. The regulation of this process remains largely unknown. In most extracellular matrices hyaluronan ... -
Functional Characterization of a Small Conductance GIRK Channel in Rat Atrial Cells
(East Carolina University, 2004-11)Muscarinic K1 (KACh) channels are key determinants of the inhibitory synaptic transmission in the heart. These channels are heterotetramers consisting of two homologous subunits, G-protein-gated inwardly rectifying K1 ... -
Functions of claudin-7 in human lung cancer
(East Carolina University, 2012)Lung cancer is the second most common cancer and the most common cause of cancer-related death in both men and women in the United States with a very poor overall 5-year survival rate. Nearly 95% of the lung cancer originates ... -
FUNCTIONS OF CLAUDIN-7 IN THE SELF-RENEWAL OF INTESTINAL EPITHELIUM
(East Carolina University, 8/5/2020)Tight junctions (TJ) are located at the most apical region of the junctional complex and contain many integral membrane proteins. Claudin 7 (Cldn7) is a TJ membrane protein located at the apical TJ and basolateral side of ...