Browsing Open Access by Type"Article"
Now showing items 101-120 of 864
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Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes
(2017-10)Although autoantibodies have been used for decades as diagnostic and prognostic markers in type 1 diabetes (T1D), further analysis of developmental abnormalities in B cells could reveal tolerance checkpoint defects that ... -
The claudin family of proteins in human malignancy: A clinical perspective
(2013-10-07)Tight junctions, or zonula occludens, are the most apical component of the junctional complex and provide one form of cell–cell adhesion in epithelial and endothelial cells. Nearly 90% of malignant tumors are derived from ... -
Claudin-7 Modulates Cl− and Na+ Homeostasis and WNK4 Expression in Renal Collecting Duct Cells
(2019-07-30)Claudin-7 knockout (CLDN7−/−) mice display renal salt wasting and dehydration phenotypes. To address the role of CLDN7 in kidneys, we established collecting duct (CD) cell lines from CLDN7+/+ and CLDN7−/− mouse kidneys. ... -
Claudin‑7 modulates cell‑matrix adhesion that controls cell migration, invasion and attachment of human HCC827 lung cancer cells
(2018-12-31)Claudins are a family of tight junction proteins, and serve important roles in epithelial barrier, selective ion transports and cancer metastasis. Although the exact role of claudin-7 in human lung cancer has not been ... -
Clinical and echocardiographic predictors of mortality in acute pulmonary embolism
(2016-10-28)Purpose: The aim of this study was to evaluate the utility of adding quantitative assessments of cardiac function from echocardiography to clinical factors in predicting the outcome of patients with acute pulmonary embolism ... -
Clinical assessment of medical students in the Emergency Department, A National Consensus Conference
(2017-01)BACKGROUND The clinical assessment of medical students in the emergency department (ED) is a highly variable process in which clerkship directors (CD) create and use institution-specific tools, many with unproven reliability ... -
Clinical Outcomes by Race and Ethnicity in the Systolic Blood Pressure Intervention Trial (SPRINT): A Randomized Clinical Trial
(2017-08-23)BACKGROUND: The Systolic Blood Pressure Intervention Trial (SPRINT) showed that targeting a systolic blood pressure (SBP) of ≤ 120 mm Hg (intensive treatment) reduced cardiovascular disease (CVD) events compared to SBP ... -
Clinical use of rifampicin during routine reporting of rifampicin susceptibilities: a lesson in selective reporting of antimicrobial susceptibility data
(1997-10)Increased use of rifampicin for in-patients was noted after the laboratory began reporting rifampicin susceptibilities routinely for all Gram-positive bacterial isolates. The appropriateness of rifampicin use was evaluated ... -
Cloning and Characterization of Ancylostoma-secreted Protein
(1996-03-22)The developmentally arrested third stage infective larva of hookworms resumes development upon entry into the definitive host. This transition to parasitism can be modeled in vitro by stimulating infective larvae with a ... -
Cloning of a catabolite repression control (crc) gene from Pseudomonas aeruginosa, expression of the gene in Escherichia coli, and identification of the gene product in Pseudomonas aeruginosa.
(1991-11)Mutants which are defective in catabolite repression control (CRC) of multiple independently regulated catabolic pathways have been previously described. The mutations were mapped at 11 min on the Pseudomonas aeruginosa ... -
Cloning of somatolactin alpha and beta cDNAs in zebrafish and phylogenetic analysis of two distinct somatolactin subtypes in fish
(2004-09-01)Somatolactin (SL) is a pituitary hormone belonging to the growth hormone/prolactin superfamily, with recognizable homologues in all fish taxa examined to date. Although sequences from most fish share reasonably high sequence ... -
Closed form bound-state perturbation theory
(1980)The perturbed Schrödinger eigenvalue problem for bound states is cast into integral form using Green's Functions. A systematic algorithm is developed and applied to the resulting equation giving rise to approximate solutions ... -
A Clostridium difficile-Specific, Gel-Forming Protein Required for Optimal Spore Germination
(2017-01-17)Clostridium difficile is a Gram-positive spore-forming obligate anaerobe that is a leading cause of antibiotic-associated diarrhea worldwide. In order for C. difficile to initiate infection, its aerotolerant spore form ... -
Co-occurrence of ecologically similar species of Hawaiian spiders reveals critical early phase of adaptive radiation
(2018-06-19)Background: The processes through which populations originate and diversify ecologically in the initial stages of adaptive radiation are little understood because we lack information on critical steps of early divergence. ... -
Coagulation Factor XIIIa Undergoes a Conformational Change Evoked by Glutamine Substrate
(1988-06-05)Coagulation factor XIIIa, plasma transglutaminase(endo-g-glutamine:e-lysine transferase EC 2.3.2.13) cata-lyzes isopeptide bond formation between glutamine andlysine residues and rapidly cross-links fibrin clots. ... -
Coastal barrier stratigraphy for Holocene high-resolution sea-level reconstruction
(2016-12-08)The uncertainties surrounding present and future sea-level rise have revived the debate around sea-level changes through the deglaciation and mid- to late Holocene, from which arises a need for high-quality reconstructions ... -
Cohomology classes associated to anomalies
(1993-12)One of the proposed settings for the description of anomalies in the setting of gauge field theories is a local bicomplex associated to a principal fiber bundle $ G \to P \to M$. It is a bigraded algebra with two differentials ... -
Combination of Raman tweezers and quantitative differential interference contrast microscopy for measurement of dynamics and heterogeneity during the germination of individual bacterial spores
(2010-09-01)Raman tweezers and quantitative differential interference contrast (DIC) microscopy are combined to monitor the dynamic germination of individual bacterial spores of Bacillus species, as well as the heterogeneity in this ... -
Combined effect of free and forced convection on MHD flow in a rotating porous channel
(1982)This paper gives a steady linear theory of the combined effect of the free and forced convection in rotating hydromagnetic viscous fluid flows in a porous channel under the action of a uniform magnetic field. The flow is ...