Browsing Open Access by Title
Now showing items 594-613 of 866
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Phosphodiesterases regulate BAY 41-2272-induced VASP phosphorylation in vascular smooth muscle cells
(2012-02-07)BAY 41-2272 (BAY), a stimulator of soluble guanylyl cyclase, increases cyclic nucleotides and inhibits proliferation of vascular smooth muscle cells (VSMCs). In this study, we elucidated mechanisms of action of BAY in its ... -
Phosphorylation state of a Tob/BTG protein, FOG-3, regulates initiation and maintenance of the Caenorhabditis elegans sperm fate program
(2011-05-12)FOG-3, the single Caenorhabditis elegans Tob/BTG protein, directs germ cells to adopt the sperm fate at the expense of oogenesis. Importantly, FOG-3 activity must be maintained for the continued production of sperm that ... -
Phylogenomic Reconstruction of the Neotropical Poison Frogs (Dendrobatidae) and Their Conservation
(2019-01-29)The evolutionary history of the Dendrobatidae, the charismatic Neotropical poison frog family, remains in flux, even after a half-century of intensive research. Understanding the evolutionary relationships between dendrobatid ... -
Physical activity is reduced prior to ventricular arrhythmiasin patients with a wearable cardioverter defibrillator
(2019-10-23)The utility of accelerometer‐based activity data to identify patients at risk of sustained ventricular tachycardia (VT) or ventricular fibrillation (VF) has not previously been investigated. The aim of the current study ... -
Physical Activity Levels in Urban-Based South African Learners: A Cross-Sectional Study of 7 348 Participants
(2018-02-01)Background: Establishing profiles of physical activity (PA) is critical in tackling the chronic diseases associated with lack of PA and avoiding healthcare costs. Objective: To investigate PA levels in urban-based South ... -
PI3K isoform inhibition associated with anti Bcr-Abl drugs shows in vitro increased anti-leukemic activity in Philadelphia chromosome-positive B-acute lymphoblastic leukemia cell lines
(2017-02-20)B-acute lymphoblastic leukemia (B-ALL) is a malignant disorder characterized by the abnormal proliferation of B-cell progenitors. Philadelphia chromosome-positive (Ph+) B-ALL is a subtype that expresses the Bcr-Abl fusion ... -
A pilot project to increase health literacy among youth from seasonal farmworker families in rural eastern North Carolina: a qualitative exploration of implementation and impact
(2019-04)Objective There are substantial health inequalities for seasonal agricultural workers and their families in the United States. One identified inequality is in health literacy. The authors explored the implementation and ... -
Pineal Region Glioblastoma, a Case Report and Literature Review
(2017-06-12)Introduction: Pineal region glioblastoma multiforme (GBM) is a rare disease entity with a generally poor prognosis. We present a case of a patient with an unresectable pineal region GBM treated with chemoradiation with ... -
Pioglitazone Enhances the Beneficial Effects of Glucocorticoids in Experimental Nephrotic Syndrome
(2016-05)Glucocorticoids are the primary therapy for nephrotic syndrome (NS), but have serious side effects and are ineffective in ~20-50% of patients. Thiazolidinediones have recently been suggested to be renoprotective, and to ... -
Pivotal Role of Adenosine Neurotransmission in Restless Legs Syndrome
(2018-01-08)The symptomatology of Restless Legs Syndrome (RLS) includes periodic leg movements during sleep (PLMS), dysesthesias, and hyperarousal. Alterations in the dopaminergic system, a presynaptic hyperdopaminergic state, seem ... -
Plant genome editing with TALEN and CRISPR
(2017-04-24)Genome editing promises giant leaps forward in advancing biotechnology, agriculture, and basic research. The process relies on the use of sequence specific nucleases (SSNs) to make DNA double stranded breaks at user defined ... -
Plasma Irisin Modestly Increases during Moderate and High-Intensity Afternoon Exercise in Obese Females
(2017-01-26)Background and Purpose Irisin is an exercise-responsive myokine that has been proposed to exert anti-obesity bene- fits; yet its response during exercise in obese women is not described. This study character- ized plasma ... -
The Plight of the Minority Resident Physician— Similar Challenges in a Different World
(2018-09-28)In the article “Minority Resident Physicians’ Views on the Role of Race/Ethnicity in Their Training Experiences in the Workplace,” Osseo-Asare et al1 report a qualitative approach to teasing out the plight of underrepresented ... -
Polymorphisms in TNF Receptor Superfamily 1B (TNFRSF1B:rs3397) are Linked to Mycobacterium avium paratuberculosis Infection and Osteoporosis in Rheumatoid Arthritis
(2019-12-04)We previously discovered that single nucleotide polymorphisms (SNPs) in PTPN2/22 (T-cell negative-regulators) occur in 78% of rheumatoid arthritis (RA), along with Mycobacterium avium paratuberculosis (MAP) infection in ... -
Polytobacco use and multiple-product smoking among a random community sample of African-American adults
(2013-11-01)Objectives Little is known about polytobacco use among African-American adults. This study is the first to explore this among a random, statewide, community sample of African-American adults. Setting Community-based sampling ... -
The Populus holobiont: dissecting the effects of plant niches and genotype on the microbiome
(2018-02-12)Background: Microorganisms serve important functions within numerous eukaryotic host organisms. An understanding of the variation in the plant niche-level microbiome, from rhizosphere soils to plant canopies, is imperative ... -
Position Paper From the Association of Pathology Chairs: Assessing Autopsy Competency in Pathology Residency Training
(2018-12-10)Declining numbers of hospital autopsies performed in US pathology residency training programs and perceived declining practice of autopsy by many pathologists has caused stakeholder organizations to reassess the role of ... -
Position Paper From the Association of Pathology Chairs: Surgical Pathology Residency Training
(2018-12-10)Training in surgical pathology specimen dissection and microscopic diagnosis is an integral part of pathology residency training, as surgical pathology is one of the defining activities of most pathologists. The Accreditation ... -
Positive mRNA Translational Control in Germ Cells by Initiation Factor Selectivity
(2015)Ultimately, the production of new proteins in undetermined cells pushes them to new fates. Other proteins hold a stem cell in a mode of self-renewal. In germ cells, these decision-making proteins are produced largely from ... -
Post-transcriptional Gene Silencing Induced by Short Interfering RNAs in Cultured Transgenic Plant Cells
(2004-05)Short interfering RNA (siRNA) is widely used for studying post-transcriptional gene silencing and holds great promise as a tool for both identifying function of novel genes and validating drug targets. Two siRNA fragments ...