Browsing Open Access by Title
Now showing items 759-778 of 866
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The state of the science of nurse work environments in the United States: A systematic review
(2018-04-16)A healthy nurse work environment is a workplace that is safe, empowering, and satisfying. Many research studies were conducted on nurse work environments in the last decade; however, it lacks an overview of these research ... -
Stem cell models of human synapse development and degeneration
(2018-11-26)Many brain disorders exhibit altered synapse formation in development or syn- apse loss with age. To understand the complexities of human synapse development and degeneration, scientists now engineer neurons and brain ... -
Step-wise evolution of complex chemical defenses in millipedes: a phylogenomic approach
(2018-02-16)With fossil representatives from the Silurian capable of respiring atmospheric oxygen, millipedes are among the oldest terrestrial animals, and likely the first to acquire diverse and complex chemical defenses against ... -
STepped exercise program for patients with knee OsteoArthritis (STEP-KOA): protocol for a randomized controlled trial
(2019-05-28)Background: Physical therapy (PT) and other exercise-based interventions are core components of care for knee osteoarthritis (OA), but both are underutilized, and some patients have limited access to PT services. This ... -
Strategies to improve palatability and increase consumption intentions for momordica charantia (bitter melon): A vegetable commonly used for diabetes management
(2011-07-28)Background Although beneficial to health, dietary phytonutrients are bitter, acid and/or astringent in taste and therefore reduce consumer choice and acceptance during food selection. Momordica charantia, commonly known ... -
Stratifying Intraductal Papillary Mucinous Neoplasms by Cyst Fluid Analysis: Present and Future
(2020-02-09)A significant proportion of patients with intraductal papillary mucinous neoplasms (IPMNs) undergo surgical resection in order to prevent or treat pancreatic cancer at the risk of significant perioperative morbidity. ... -
Strength training for arthritis trial (START): Design and rationale
(2013-07-15)Background Muscle loss and fat gain contribute to the disability, pain, and morbidity associated with knee osteoarthritis (OA), and thigh muscle weakness is an independent and modifiable risk factor for it. However, while ... -
Stressing the heart of the matter: Re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids
(2012-07-02)Despite their clear therapeutic effects in coronary heart disease, use of n-3 polyunsaturated fatty acids (PUFAs) to treat other types of cardiovascular disease remains controversial, and serious obstacles exist in ... -
Strongly interacting matter under rotation
(2018-02-02)The vorticity-driven effects are systematically studied in various aspects. With AMPT the distributions of vorticity has been investigated in heavy ion collisions with different collision parameters. Taking the rotational ... -
Structural characterisation of mangrove forests achieved through combining multiple sources of remote sensing data
(2019-11-14)Temporal information on mangrove extent, age, structure and biomass provides an important contribution towards understanding the role of these ecosystems in terms of the services they provide (e.g., in relation to storage ... -
Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes
(2019-03-21)The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto, termed BBK32-C, binds and inhibits the initiating serine protease of the human classical complement pathway, C1r. In this study we ... -
Structural Dynamics of Troponin I during Ca2+-Activation of Cardiac Thin Filaments: A Multi-Site Förster Resonance Energy Transfer Study
(2012-12)A multi-site, steady-state Förster resonance energy transfer (FRET) approach was used to quantify Ca2+-induced changes in proximity between donor loci on human cardiac troponin I (cTnI), and acceptor loci on human cardiac ... -
Structural insights into flagellar stator– rotor interactions
(2019-07-17)The bacterial flagellar motor is a molecular machine that can rotate the flagellar filament at high speed. The rotation is generated by the stator–rotor interaction, coupled with an ion flux through the torque-generating ... -
Study of Image Qualities From 6D Robot–Based CBCT Imaging System of Small Animal Irradiator
(2017-12)Purpose: To assess the quality of cone beam computed tomography images obtained by a robotic arm-based and image-guided small animal conformal radiation therapy device. Method and Materials: The small animal conformal ... -
Subcellular fractionation method to study endosomal trafficking of Kaposis sarcoma-associated herpesvirus
(2016)Background: Virus entry involves multiple steps and is a highly orchestrated process on which successful infection collectively depends. Entry processes are commonly analyzed by monitoring internalized virus particles via ... -
Substrate utilization during submaximal exercise in children with a severely obese parent
(2012-05-09)Background We have reported a reduction in fatty acid oxidation (FAO) at the whole-body level and in skeletal muscle in severely obese (BMI ≥ 40 kg/m2) individuals; this defect is retained in cell culture suggesting an ... -
Susceptibility and Antibody Response of the Laboratory Model Zebra Finch (Taeniopygia guttata) to West Nile Virus
(2017-01-03)Since the introduction of West Nile virus (WNV) into North America in 1999 a number of pas- serine bird species have been found to play a role in the amplification of the virus. Arbovirus surveillance, observational studies ... -
Synchronized Beta-Band Oscillations in a Model of the Globus Pallidus - Subthalamic Nucleus Network under External Input
(2016)Hypokinetic symptoms of Parkinson’s disease are usually associated with the excessively strong oscillations and synchrony in the beta frequency band. The origin of this synchronized oscillatory dynamics is being debated. ... -
A systematic mRNA control mechanism for germline stem cell homeostasis and cell fate specification
(2016-02)Germline stem cells (GSCs) are the best understood adult stem cell types in the nematode Caenorhabditis elegans, and have provided an important model system for studying stem cells and their cell fate in vivo, in mammals. ... -
A system‐based intervention to reduce Black‐White disparities in the treatment of early stage lung cancer: A pragmatic trial at five cancer centers
(2019-01-11)Background: Advances in early diagnosis and curative treatment have reduced high mortality rates associated with non‐small cell lung cancer. However, racial disparity in survival persists partly because Black patients ...