Browsing Open Access by Author "Yang, Li V."
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Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells
Dong, Lixue; Krewson, Elizabeth A.; Yang, Li V. (2017-01-27)Acidosis commonly exists in the tissue microenvironment of various pathophysiological conditions such as tumors, inflammation, ischemia, metabolic disease, and respiratory disease. For instance, the tumor microenvironment ... -
Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies
Justus, Calvin R.; Sanderlin, Edward J.; Dong, Lixue; Sun, Tianai; Chi, Jen-Tsan; Lertpiriyapong, Kvin; Yang, Li V. (2017-12)Background: Extracellular acidosis is a condition found within the tumor microenvironment due to inadequate blood perfusion, hypoxia, and altered tumor cell metabolism. Acidosis has pleiotropic effects on malignant progres‐ ... -
Emerging roles for the pH-sensing G protein-coupled receptors in response to acidotic stress
Sanderlin, Edward J; Justus, Calvin R.; Krewson, Elizabeth A.; Yang, Li V. (2015)Protons (hydrogen ions) are the simplest form of ions universally produced by cellular metabolism including aerobic respiration and glycolysis. Export of protons out of cells by a number of acid transporters is essential ... -
Isolated neutropenia as a rare but serious adverse event secondary to immune checkpoint inhibition
Naqash, Abdul Rafeh; Appah, Ebenezer; Yang, Li V.; Muzaffar, Mahvish; Marie, Mona A.; Mccallen, Justin D.; Macherla, Shravanti; Liles, Darla; Walker, Paul R. (2019-07-05)Background Compared to conventional chemotherapy, Immune checkpoint inhibitors (ICI) are known to have a distinct toxicity profile commonly identified as immune-related adverse events (irAEs). These irAEs that are believed ... -
Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment
Calvin, Justin R.; Sanderlin, Edward J.; Yang, Li V. (2015)Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the “Warburg effect”, commonly ... -
The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells
Krewson, Elizabeth A.; Sanderlin, Edward J.; Marie, Mona A.; Akhtar, Shayan Nik; Velcicky, Juraj; Loetscher, Pius; Yang, Li V. (2020-02-21)be activated by protons in the inflamed tissue microenvironment. Herein, we report that acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelialcells through the ... -
Quantitative analysis and comparison of 3D morphology between viable and apoptotic MCF-7 breast cancer cells and characterization of nuclear fragmentation
Wen, Yuhua; Chen, Zhan; Lu, Jianfen; Ables, Elizabeth Tweedie; Scemama, Jean-Luc; Yang, Li V.; Lu, Jun Q.; Hu, Xin-Hua (2017-09-08)Morphological changes in apoptotic cells provide essential markers for defining and detec- tion of apoptosis as a fundamental mechanism of cell death. Among these changes, the nuclear fragmentation and condensation have ... -
Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells
McCubrey, James A.; Fitzgerald, Timothy L.; Yang, Li V.; Lertpiriyapong, Kvin; Steelman, Linda S.; Abrams, Stephen L.; Montalto, Giuseppe; Cervello, Melchiorre; Neri, Luca M.; Cocco, Lucio; Martelli, Alberto M.; Laidler, Piotr; Dulińska-Litewka, Joanna; Rakus, Dariusz; Gizak, Agnieszka; Nicoletti, Ferdinando; Falzone, Luca; Candido, Saverio; Libra, Massimo (2017-02)Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/ Akt/mTORC, Ras/Raf/MEK/ERK, hedgehog (Hh), Notch and TP53 ... -
Tumor Microenvironment and Metabolism
Yang, Li V. (2017-12-16)The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. Cancer cells co-exist with infiltrated immune cells, blood vessels, fibroblasts, and other stromal cells in the ...