Browsing Open Access by Subject "Hepatocellular carcinoma, MK-2206, Akt-1, targeted therapy, apoptosis, autophagy"
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The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy (2013-08-24)Hepatocellular carcinoma (HCC) is one of the most common potentially lethal human malignancies worldwide. Advanced or recurrent HCC is frequently resistant to conventional chemotherapeutic agents and radiation. Therefore, ...