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Cardiac amyloidosis: A case report and review of literature
(2019-03-26)
BACKGROUND
Cardiac amyloidosis, a disease caused by the precipitation of amyloid proteins in
the myocardial extracellular matrix has been historically difficult to diagnose due
to lack of specific clinical manifestations ...
Concurrent validity of skin carotenoid status as a concentration biomarker of vegetable and fruit intake compared to multiple 24-h recalls and plasma carotenoid concentrations across one year: a cohort study
(2019-10-30)
Background
Biological markers of vegetable and fruit (VF) intake are needed both for nutrition surveillance and for the evaluation of nutrition interventions. Optically assessed skin carotenoid status (SCS) has been ...
Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells.
(2019-10-07)
Background:
The unique physicochemical properties of multi-walled carbon nanotubes (MWCNT) have led to many industrial applications. Due to their low density and small size, MWCNT are easily aerosolized in the workplace ...
Kinetics and Identities of Extracellular Peptidases in Subsurface Sediments of the White Oak River Estuary, North Carolina
(2019-09-17)
Anoxic subsurface sediments contain communities of heterotrophic microorganisms that metabolize organic carbon at extraordinarily low rates. In order to assess the mechanisms by which subsurface microorganisms access ...
Real-time compression feedback for patients with in-hospital cardiac arrest: a multi-center randomized controlled clinical trial
(2019-01-03)
Objective: To determine if real-time compression feedback using a non-automated hand-held device improves
patient outcomes from in-hospital cardiac arrest (IHCA).
Methods: We conducted a prospective, randomized, controlled, ...
Refinement of risk stratification for childhood rhabdomyosarcoma using FOXO1 fusion status in addition to established clinical outcome predictors: A report from the Children's Oncology Group
(2019-08-06)
Background:
Previous studies of the prognostic importance of FOXO1 fusion status in patients with rhabdomyosarcoma (RMS) have had conflicting results. We re‐examined risk stratification by adding FOXO1 status to traditional ...
Regulation of cardiac fibroblast-mediated maladaptive ventricular remodeling by β-arrestins
(2019-07-03)
Cardiac fibroblasts (CF) play a critical role in post-infarction remodeling which can ultimately
lead to pathological fibrosis and heart failure. Recent evidence demonstrates that remote
(non-infarct) territory fibrosis ...
Species-Specific Conservation of Linear Antigenic Sites on Vaccinia Virus A27 Protein Homologs of Orthopoxviruses
(2019-05-29)
The vaccinia virus (VACV) A27 protein and its homologs, which are found in a large number of members of the genus Orthopoxvirus (OPXV), are targets of viral neutralization by host antibodies. We have mapped six binding ...
Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by Lyme disease spirochetes
(2019-03-21)
The carboxy-terminal domain of the BBK32 protein from Borrelia burgdorferi sensu stricto, termed BBK32-C, binds and inhibits the initiating serine protease of the human classical complement pathway, C1r. In this study we ...
The concept of essential use for determining when uses of PFASs can be phased out
(2019-05-27)
Because of the extreme persistence of per- and polyfluoroalkyl substances (PFASs) and their associated risks, the Madrid Statement argues for stopping their use where they are deemed not essential or when safer alternatives ...