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Overexpression of Long-Chain Acyl-CoA Synthetase 5 Increases Fatty Acid Oxidation and Free Radical Formation While Attenuating Insulin Signaling in Primary Human Skeletal Myotubes
(2019-03-31)
In rodent skeletal muscle, acyl-coenzyme A (CoA) synthetase 5 (ACSL-5) is suggested to localize to the mitochondria but its precise function in human skeletal muscle is unknown. The purpose of these studies was to define ...
Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer
(2019-12-01)
PURPOSE:
Oral mucositis (OM) remains a common, debilitating toxicity of radiation therapy (RT) for head and neck cancer. The goal of this phase IIb, multi-institutional, randomized, double-blind trial was to compare the ...
Polymorphisms in TNF Receptor Superfamily 1B (TNFRSF1B:rs3397) are Linked to Mycobacterium avium paratuberculosis Infection and Osteoporosis in Rheumatoid Arthritis
(2019-12-04)
We previously discovered that single nucleotide polymorphisms (SNPs) in PTPN2/22 (T-cell negative-regulators) occur in 78% of rheumatoid arthritis (RA), along with Mycobacterium avium paratuberculosis (MAP) infection in ...
Opinions on the Legitimacy of Death Declaration by Neurological Criteria from the Perspective of 3 Abrahamic Faiths
(2019-09-27)
Traditional criteria to identify death may not fit all circumstances. This manuscript explores religious jurisprudence to ascertain whether death declaration by neurological criteria (DDNC) is accepted as a valid by 3 ...
Responding to health and social needs of aging Latinos in new-growth communities: a qualitative study
(2017-08)
Background: The development of new-growth communities of Latino immigrants in southern states has challenged the traditional health and social service infrastructure. An interprofessional team of service providers, Latino ...
Resurrection of the Body and Cryonics
(2017-05-18)
The Christian doctrine of resurrection of the body is employed to interpret the cryonics program of preserving legally dead people with the plan to restore them when future medicine can effectively address the cause of ...
Resume, Eulogy, Education and Future
(2017-10)
Will the current trend of the Industrial Age, focused on profits, greed, material wealth, and mass consumption continue? Inequality and polarization, which are seen in today’s world, are ranked as the top drivers of global ...
Position Paper From the Association of Pathology Chairs: Surgical Pathology Residency Training
(2018-12-10)
Training in surgical pathology specimen dissection and microscopic diagnosis is an integral part of pathology residency training, as surgical pathology is one of the defining activities of most pathologists. The Accreditation ...
Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells
(2017-02)
Various signaling pathways exert critical roles in the epithelial to mesenchymal transition (EMT) and cancer stem cells (CSCs). The Wnt/beta-catenin, PI3K/PTEN/ Akt/mTORC, Ras/Raf/MEK/ERK, hedgehog (Hh), Notch and TP53 ...
RhoGTPase Regulators Orchestrate Distinct Stages of Synaptic Development
(2017-01-23)
Small RhoGTPases regulate changes in post-synaptic spine morphology and density that support learning and memory. They are also major targets of synaptic disorders, including Autism. Here we sought to determine whether ...