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The Role of Retinoic Acid (RA) in Spermatogonial Differentiation
(2016)
Retinoic acid (RA) directs the sequential, but distinct, programs of spermatogonial differentiation and meiotic differentiation that are both essential for the generation of functional spermatozoa. These processes are ...
The role of fishing material culture in communities’ sense of place as an added-value in management of coastal areas
(2016)
Fishing communities in many places around the world are facing significant challenges
due to new policies and environmental developments. While it is imperative to ensure sustainability
of natural resources, many policies ...
Step-wise evolution of complex chemical defenses in millipedes: a phylogenomic approach
(2018-02-16)
With fossil representatives from the Silurian capable of respiring atmospheric oxygen, millipedes
are among the oldest terrestrial animals, and likely the first to acquire diverse and complex chemical defenses against ...
Phosphodiesterases regulate BAY 41-2272-induced VASP phosphorylation in vascular smooth muscle cells
(2012-02-07)
BAY 41-2272 (BAY), a stimulator of soluble guanylyl cyclase, increases cyclic nucleotides and inhibits proliferation of vascular smooth muscle cells (VSMCs). In this study, we elucidated mechanisms of action of BAY in its ...
Stem cell models of human synapse development and degeneration
(2018-11-26)
Many brain disorders exhibit altered synapse formation in development or syn- apse loss with age. To understand the complexities of human synapse development and degeneration, scientists now engineer neurons and brain ...
Q-advanced models for tsunami and rogue waves
(2012-05-21)
A wavelet [subscript] Kq[/subscript] (t ) , that satisfies the q-advanced differential equation [superscript] K q [variant prime][/superscript] ( t ) =[subscript] K q[/subscript] (qt ) for q >1 , is used to model N-wave ...
A single dose of trichloroethylene given during development does not substantially alter markers of neuroinflammation in brains of adult mice
(2017-04-03)
Trichloroethylene (TCE) is a widespread environmental contaminant associated with developmental immu- notoxicity and neurotoxicity. Previous studies have shown that MRLþ/þ mice exposed to TCE from gesta- tion through ...
Prey Responses to Predator Chemical Cues: Disentangling the Importance of the Number and Biomass of Prey Consumed
(2012-10)
To effectively balance investment in predator defenses versus other traits, organisms must accurately assess predation risk. Chemical cues caused by predation events are indicators of risk for prey in a wide variety of ...
Preclinical and Clinical Assessment of Cannabinoids as Anti-Cancer Agents
(2016-07)
Cancer is the second leading cause of death in the United States with 1.7 million
new cases estimated to be diagnosed in 2016. This disease remains a formidable
clinical challenge and represents a substantial financial ...
The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300/CBP
(2012-03-19)
The homologous cellular coactivators p300 and CBP contain intrinsic lysine acetyl transferase (termed HAT) activity. This activity is responsible for acetylation of several sites on the histones as well as modification of ...