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Now showing items 2301-2320 of 10631
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Deletion of LPCAT3 Promotes Enhanced Insulin Signaling in Skeletal Muscle
(East Carolina University, 2015-12-15)Aberrant lipid metabolism has been linked to skeletal muscle insulin resistance. The exact identity of the lipid species that promote skeletal muscle insulin resistance among the human population remains unclear. In this ... -
Deletion of Macrophage Vitamin D Receptor Promotes Insulin Resistance and Monocyte Cholesterol Transport to Accelerate Atherosclerosis in Mice
(2015)Intense effort has been devoted to understanding predisposition to chronic systemic inflammation because it contributes to cardiometabolic disease. We demonstrate that deletion of the macrophage vitamin D receptor (VDR) ... -
Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy
(2014-04)EphrinA1-EphA-receptor signaling is protective during myocardial infarction (MI). The EphA2-receptor (EphA2-R) potentially mediates cardiomyocyte survival. To determine the role of the EphA2-R in acute non-reperfused ... -
Deletion of the Protein Kinase A/Protein Kinase G Target SMTNL1 Promotes an Exercise-adapted Phenotype in Vascular Smooth Muscle
(East Carolina University, 2008-04-25)In vivo protein kinases A and G (PKA and PKG) coordinately phosphorylate a broad range of substrates to mediate their various physiological effects. The functions of many of these substrates have yet to be defined genetically. ... -
Delination of Coastal Shark Habitat within North Carolina Waters Using Acoustic Telemetry, Fisher-Independent Surveys, and Local Ecological Knowledge
(East Carolina University, 2016-07-20)Knowledge of shark habitat preferences and use patterns is important to effectively manage shark fisheries and account for interactions between sharks and species targeted by other fishery management or conservation efforts. ... -
DELINEATING THE MECHANISM OF AGGREGATE OR BIOFILM FORMATION IN THE LYME DISEASE SPIROCHETE BORRELIA BURGDORFERI
(East Carolina University, 2021-07-14)Borrelia burgdorferi, the spirochete causing Lyme disease, is transmitted to a vertebrate host by the bite of an infected Ixodes scapularis tick. The spirochete develops antibiotic resistance in humans likely due to the ... -
DELINEATING THE ROLE OF SOLUBLE CD25 AS AN IMMUNOREGULATORY MOLECULE THAT PROMOTES A LOW-ZONE IL-2 SIGNALING ENVIRONMENT FAVORABLE FOR THE SELECTION OF CD25HIGH FOXP3HIGH T CELLS
(East Carolina University, 2021-07-22)Autoimmune diseases develop due to the breakdown of tolerogenic mechanisms that normally maintain immune homeostasis. CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) are critical in the maintenance of tolerance and the ... -
Delineating Wastewater Contaminant Plumes from On-Site Wastewater Treatment Systems in the North Carolina Coastal Plain using Electromagnetic Induction
(East Carolina University, 2016-08-18)In North Carolina, wastewater-derived nutrients and harmful bacteria threaten public health and reduce water quality for many surface water bodies. North Carolina uses ~ 2 million on-site wastewater treatment systems, yet ... -
Delineation and mapping of coastal shark habitat within a shallow lagoonal estuary
(2018-04-12)Estuaries function as important nursery and foraging habitats for many coastal species, including highly migratory sharks. Pamlico Sound, North Carolina, is one of the largest estuaries in the continental United States and ... -
The delta-14 Mutation of Human Cardiac Troponin T Enhances ATPase Activity and Alters the Cooperative Binding of S1-ADP to Regulated Actin
(East Carolina University, 2004-12-07)The complex of tropomyosin and troponin binds to actin and inhibits activation of myosin ATPase activity and force production of striated muscles at low free Ca2+ concentrations. Ca2+ stimulates ATP activity, and at ... -
Delta-Catenin Induced Dendritic Morphogenesis: An Essential Role of p190RhoGEF Interaction through Akt1 Mediated Phosphorylation
(East Carolina University, 2008-01-11)delta-Catenin was first identified through its interaction with Presenilin-1 and has been implicated in the regulation of dendrogenesis and cognitive function. However, the molecular mechanisms by which delta-catenin ... -
delta-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles
(East Carolina University, 2009-03-10)Background: delta-Catenin is a unique member of delta-catenin/armadillo domain superfamily proteins and its primary expression is restricted to the brain. However, delta-catenin is upregulated in human prostatic adenocarcinomas, ... -
[Delta]-catenin: implications in prostate cancer progression
(East Carolina University, 2014)Prostate cancer (PCa) is the most commonly diagnosed cancer and the second most common cause of cancer death among men in the US. Due to the advances in research, the ability to detect and cure PCa has improved and led to ... -
Dementia with Dignity: Methods to Reduce Incidence and Severity of Challenging Encounters
(2024-04-18)Psychological and behavioral challenges are frequently exhibited by individuals living with dementia. Often the interaction between a caregiver and the individual is the precipitant for those behaviors. The leadership of ... -
Democedes of Corton and the State of Pre-Hippocratic Medicine in Ancient Greece
(2008-11-03)Laupus Library History Collections & the Department of Bioethics & Interdisciplinary Studies sponsor the History of Medicine Presentations as an educational service for the East Carolina University community. The Library ... -
A Democratic Art
(East Carolina University, 2013)This is a report on my creative research and it is written in support of my thesis exhibition entitled A Democratic Art. This thesis is an investigation into the ways printmaking is celebrated within the printmaking ... -
DEMOGRAPHIC AND BEHAVIORAL RISK FACTORS ASSOCIATED WITH HIV INFECTION IN ETHIOPIAN ADOLESCENTS
(East Carolina University, 2022-05-09)HIV is still a global issue, particularly among young adolescents. According to UNICEF, they carry the burden of the disease at approximately 5% of all people living with HIV and about 11% of new adult HIV infections. The ... -
Demystifying Fund Allocation Formulas in an Academic Library Setting
(2013-10-16)This presentation gave an overview of different types of allocation formulas in use at academic libraries and then focused on Joyner Library's recently developed model which incorporates a use factor measure.