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Antigen-specific tolerogenic vaccines inhibit autoimmune disease in a rodent model of multiple sclerosis
(East Carolina University, 2010)Multiple sclerosis (MS) is considered to be a T cell-mediated autoimmune disease directed against myelinated nerves within the central nervous system. Current therapies available to MS patients have low efficacy and are ... -
Antisense oligonucleotide and thyroid hormone conjugates for obesity treatment
(2017-08-24)Using the principle of antibody-drug conjugates that deliver highly potent cytotoxic agents to cancer cells for cancer therapy, we here report the synthesis of antisense-oligonucleotides (ASO) and thyroid hormone T3 ... -
Antiseptic Humor : Using Comedy To Confront Realities And Refute Stereotypes In The Works Of Sherman Alexie
(East Carolina University, 2015)Sherman Alexie, a Native American author of poems, novels, plays, and film uses humor to expose and to explore lingering cultural stereotypes affecting people of Native American ancestry. These stereotypes often conflict ... -
Antitumor Mechanism of the Essential Oils from Two Succulent Plants in Multidrug Resistance Leukemia Cell
(2019-08-26)Drug resistance remains a major challenge in the treatment of cancer. The multiplicity of the drug resistance determinants raises the question about the optimal strategies to deal with them. Essential oils showed to ... -
Antivenom Treatment Is Associated with Fewer Patients using Opioids after Copperhead Envenomation
(2019-03-20)Introduction Copperhead envenomation causes local tissue destruction, leading people to seek treatment for the pain and swelling. First-line treatment for the pain is opioid medications. There is rising concern that an ... -
Anxiety and College Students: The Benefits of Mindfulness Based Mediation
(East Carolina University, 2018-04-24)Approximately 62% of college students report experiencing anxiety during the past 12 months (American College Health Association [ACHA], 2016). Of those students, approximately 27% stated that their anxiety had taken a ... -
Anxiety and Family Functioning in Children with Food Allergies
(East Carolina University, 2015-12-10)Having a food allergy is a stressful thing for a child and their family. This is a chronic illness that requires vigilance, time, and effort in order to prevent anaphylaxis, a life threatening allergic reaction. There has ... -
ANXIETY AND FEAR IN RELATION TO SLEEP AND NEUROPHYSIOLOGY IN A SAMPLE OF COLLEGE STUDENTS
(East Carolina University, 2019-12-12)Long-term poor sleep contributes to the development and maintenance of chronic disease and physical and mental health challenges. Researchers have sought to understand the myriad of factors that influence sleep behavior, ... -
Anything is Possible
(East Carolina University, 2019-11-26)Love is like an Ironman Triathlon - filled with highs and lows, way longer and tougher than a marathon and a hundred and fourteen times more worth it. Henry and Allison clicked from the moment they met in the TV newsroom ... -
Apigenin prevents chemically-induced skin tumor formation and inhibits COX-2 expression and activity in SKH-1 mouse epidermis
(East Carolina University, 2012)The most common type of cancer in the United States is non-melanoma skin cancer (NMSC), with an estimated two million new cases diagnosed each year. Numerous malignancies including NMSC, colon, breast, and prostate cancer ... -
Apigenin Prevents UVB-Induced Cyclooxygenase 2 Expression: Coupled mRNA Stabilization and Translational Inhibition
(East Carolina University, 2007-01)Cyclooxygenase 2 (COX-2) is a key enzyme in the conversion of arachidonic acid to prostaglandins, and COX-2 overexpression plays an important role in carcinogenesis. Exposure to UVB strongly increased COX-2 protein expression ... -
Apoptosis mechanisms induced by 15d-PMJ2 in HCT116 colon cancer cells: insights into CHOP10/TRB3/Akt signaling
(2023-11-02)Agents that stimulate the endoplasmic reticulum (ER) stress pathway are being exploited pharmacologically to induce cancer cell death. Cytotoxic ER stress is typically regulated by the transcription factor, C/EBP homologous ... -
Apparatus and method for measuring physiological characteristics of an intact trachea in vitro
(2011-03-15)Apparatus and methods for measuring smooth muscles responses (relaxation and contraction), transepithelial potential difference, and/or transepithelial impedance of an intact trachea in vitro. In particular embodiments, ... -
Apparent Feminist Pedagogies Interrogating Technical Rhetorics at Illinois State University
(2014)This curriculum showcase introduces apparent feminist pedagogies and reports on their use in a technical rhetorics course at Illinois State University. I describe the exigence for apparent feminist pedagogies, which seek ... -
An Appetite for Metaphor : Food Imagery and Cultural Identity in Indian Fiction
(East Carolina University, 2011)Postmodern culture has been greatly influenced by food images and the usage of food as metaphor. Recent interest in food studies has opened doors in literary studies to examine how the use of food imagery and metaphor ...