Browsing by Author "Dohm, G. Lynis"
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A study of some biochemical adaptations to exercise training
Stephenson, Thomas Patrick. -
Amino acid oxidation in skeletal muscle :adaption to endurance training
Brown, William E. -
The Association Between Lactate and Muscle Aerobic Substrate Oxidation: Is Lactate an Early Marker for Metabolic Disease in Healthy Subjects?
Broskey, Nicholas T.; Tanner, Charles J.; Zheng, Donghai; Cortright, Ronald N.; Yang, Zhen W.; Khang, Nkaujyi; Houmard, Joseph A.; Pories, Walter J.; Jones, Terry E.; Yang, Josh; Dohm, G. Lynis (2021) -
Changes in muscle strength, muscle fibre size and myofibrillar gene expression after immobilization and retraining in humans
Hortobágyi, Tibor; Dempsey, G. Lynis; Fraser, D. D.; Zheng, D.; Hamilton, G.; Lambert, J.; Dohm, G. Lynis (East Carolina University, 2000-01)1. Changes in muscle strength, vastus lateralis fibre characteristics and myosin heavychain (MyoHC) gene expression were examined in 48 men and women following 3 weeks of knee immobilization and after 12 weeks of retraining ... -
Characterization of a Low Affinity Thyroid Hormone Receptor Binding Site within the Rat GLUT4 Gene Promoter
Torrance, Christopher J.; Usala, Stephen J.; Pessin, Jeffrey E.; Dohm, G. Lynis (1997-03)Previous studies have demonstrated that thyroid hormone (T3) stimulates insulin-responsive glucose transporter (GLUT4) transcription and protein expression in rat skeletal muscle. The aim of the present study was to define ... -
Contractile activity restores insulin responsiveness in skeletal muscle of obese Zucker rats.
Dolan, Patricia L.; Tapscott, Edward B.; Dorton, Peter J.; Dohm, G. Lynis (East Carolina University, 1993-01-15)Both insulin and contraction stimulate glucose transport in skeletal muscle. Insulin-stimulated glucose transport is decreased in obese humans and rats. The aims of this study were (1) to determine if contraction-stimulated ... -
Diabetes: Have we got it all wrong? Hyperinsulinism as the culprit: Surgery provides the evidence
Pories, Walter J.; Dohm, G. Lynis (2012-12) -
The effect of fasting on the activation in vivo of the insulin receptor kinase.
Contreras, Ivan; Dohm, G. Lynis; Abdallah, Silvia; Wells, James A.; Mooney, Nitin; Rovira, Adela; Caro, Jose F. (East Carolina University, 1990-02-01)Fasting causes insulin resistance in liver and fat, and increases insulin sensitivity in muscle. We studied the response in vitro and in vivo to insulin of the insulin receptor tyrosine kinase in muscle and liver from 72 ... -
An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects.
Dohm, G. Lynis; Tapscott, Edward B.; Pories, Walter J.; Dabbs, David J.; Flickinger, Edward G.; Meelheim, Diane; Fushiki, Tohru; Atkinson, Samuel M.; Elton, Charles W.; Caro, Jose F. (East Carolina University, 1988-08)We have developed an in vitro muscle preparation suitable for metabolic studies with human muscle tissue and have investigated the effects of obesity and non-insulin-dependent diabetes mellitus (NIDDM) on glucose transport. ... -
Insulin responsiveness in skeletal muscle is determined by glucose transporter (Glut4) protein level.
Kern, Marialice; Wells, James A.; Stephens, Jacqueline M.; Elton, Charles W.; Friedman, Jacob E.; Tapscott, Edward B.; Pekala, Phillip H.; Dohm, G. Lynis (East Carolina University, 1990-09-01)Glucose transport in skeletal muscle is mediated by two distinct transporter isoforms, designated muscle/adipose glucose transporter (Glut4) and erythrocyte/HepG2/brain glucose transporter (Glutl), which differ in both ... -
Is there a metabolic program in the skeletal muscle of obese individuals?
Houmard, Joseph A.; Pories, Walter J.; Dohm, G. Lynis (2011-04-26)Severe obesity (BMI ≥ 40 kg/m2) is associated with multiple defects in skeletal muscle which contribute to insulin resistance and a reduction in fatty acid oxidation (FAO) in this tissue. These metabolic derangements are ... -
Is type II diabetes mellitus (NIDDM) a surgical disease?
Pories, Walter J.; MacDonald, Kenneth G. Jr.; Flickinger, Edward G.; Dohm, G. Lynis; Sinha, Madhur K.; Barakat, Hisham A.; May, Harold J.; Khazanie, Prabhaker; Swanson, Melvin S.; Morgan, Elizabeth J.; Leggett-Frazier, Nancy; Long, Stuart D.; Brown, Brenda M.; O'Brien, Kevin F.; Caro, Jose F. (East Carolina University, 1992-06)Since February 1, 1980, 515 morbidly obese patients have undergone the Greenville gastric bypass (GGB) operation. Of these, 212 (41.2%) were euglycemic, 288 (55.9%) were either diabetic or had glucose intolerance, and ... -
Mechanism for Improved Insulin Sensitivity after Gastric Bypass Surgery
Bikman, Benjamin Thomas; Zheng, Donghai; Pories, Walter J.; Chapman, William H. H.; Pender, John R.; Bowden, Rita C.; Reed, Melissa A.; Cortright, Ronald N.; Tapscott, Edward B.; Houmard, Joseph A.; Tanner, Charles J.; Lee, Jihyun; Dohm, G. Lynis (East Carolina University, 2008-12)Context: Surgical treatments of obesity have been shown to induce rapid and prolonged improvements in insulin sensitivity. Objective: The aim of the study was to investigate the effects of gastric bypass surgery and the ... -
Metformin Improves Insulin Signaling in Obese Rats via Reduced IKK Action in a Fiber-Type Specific Manner
Bikman, Benjamin Thomas; Zheng, Donghai; Kane, Daniel A.; Anderson, Ethan; Woodlief, Tracey L.; Price, Jesse W.; Dohm, G. Lynis; Neufer, P. Darrell; Cortright, Ronald N. (2010)Metformin is a widely used insulin-sensitizing drug, though its mechanisms are not fully understood. Metformin has been shown to activate AMPK in skeletal muscle; however, its effects on the inhibitor of κB kinaseβ (IKKβ) ... -
Modulation of IKKβ with AMPK Improves Insulin Sensitivity in Skeletal Muscle
Bikman, Benjamin Thomas (East Carolina University, 2008-11)Activation of the insulin receptor substrate (IRS)-1 is necessary for proper transduction of the insulin signal. IRS-1 serine312(human)/307(rodent) phosphorylation, however, results in disruption of this signal and subsequent ... -
Peroxisome Proliferator–Activated Receptor-γ Coactivator-1α Overexpression Increases Lipid Oxidation in Myocytes From Extremely Obese Individuals
Consitt, Leslie A.; Bell, Jill A.; Koves, Timothy R.; Muoio, Deborah M.; Hulver, Matthew W.; Haynie, Kimberly R.; Dohm, G. Lynis; Houmard, Joseph A. (2010-06) -
Potential Mechanisms for Amelioration of Type 2 Diabetes Following Bariatric Surgery
Reed, Melissa Anne (East Carolina University, 2011)Severe obesity and Type 2 Diabetes (T2DM) are worldwide health concerns reaching epidemic proportions. Roux-en-Y gastric bypass (RYGB) has been shown to elicit a rapid and durable improvement and/or remission of T2DM in ... -
Regulation of GLUT4 expression in denervated skeletal muscle
Jensen, Ellis B.; Zheng, Donghai; Russell, Robert A.; Bassel-Duby, Rhonda; Williams, R. Sanders; Olsen, Ann Louise; Dohm, G. Lynis (East Carolina University, 2009-03)Denervation by sciatic nerve resection causes decreased muscle glucose transporter 4 (GLUT4) expression, but little is known about the signaling events that cause this decrease. Experiments were designed to test the ...