Browsing Dissertations and Theses by Author "Chemistry"
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Quantifying Dissolved Lignin Phenols in the Albemarle–Pamlico Estuarine System and Coastal North Carolina following the 2018 Hurricane Florence
Ferris, Kathleen J (East Carolina University, 2022-08-19)The global carbon cycle (GCC) involves the exchange and transformation of carbon across the ocean, atmosphere, and terrestrial reservoirs. It consists of a positive feedback loop involving dissolved organic matter in natural ... -
Quantifying Dissolved Lignin Phenols in the Albemarle–Pamlico Estuarine System and Coastal North Carolina following the 2018 Hurricane Florence
Ferris, Katie (East Carolina University, 2022-08-19)The global carbon cycle (GCC) involves the exchange and transformation of carbon across the ocean, atmosphere, and terrestrial reservoirs. It consists of a positive feedback loop involving dissolved organic matter in natural ... -
A quantitative and nondestructive method for determining the degradation of waterlogged archaeological wood
Bingham, Jessica (East Carolina University, 2013)Archaeological artifacts are an essential part of preserving history and culture, and can be valuable tools for enhancing education and contributing economic benefits through tourism. Of the artifacts that one may encounter, ... -
Quinone Formation via Ceric Ammonium Nitrate Oxidations of 2-Alkyl-1,4-dialkoxybenzenes
Simmons, Alexander Linwood (East Carolina University, 2016-05-03)Quinones are cyclohexadiendiones that have a variety of uses ranging from medical applications to synthetic building blocks. Medicinal applications stem from the potent biological activity (e.g. antitumor and antibiotic) ... -
Red Blood Cell Preservation Under Austere Conditions
Angermeier, Tori Marena (East Carolina University, 2023-01-05)In the United States, the maximum approved preservation time for red blood cells under hypothermic storage conditions is 42 days when treated with an appropriate additive solution, namely AS-1. In this investigation, we ... -
SCREENING AND CHARACTERIZATION OF BIOCATALYSTS FOR SYNTHESIS OF WIELAND MIESCHER KETONE: A VERSATILE SYNTHETIC INTERMEDIATE
Patel, Mitul P (East Carolina University, 2020-12-07)Biocatalysts derived from biological molecules such as proteins, RNA, and DNA have long been exploited for applications in synthetic chemistry. Lipases, a versatile class of biocatalysts, are known to exhibit significant ... -
SEPARATION AND ANALYSIS OF PRESERVATIVES IN SKINCARE CREAMS BY HIGH TEMPERATURE LIQUID CHROMATOGRAPHY AND SUBCRITICAL WATER CHROMATOGRAPHY
Gujjar, Leena (East Carolina University, 2011)Preservatives are chemicals with antimicrobial activity commonly added to foods, pharmaceuticals and cosmetics in order to prolong products' shelf life and to protect the consumer from potential infection. Parabens, the ... -
Solvent and Solubility Effects on Quinone Ratios
Duffy, Brian (East Carolina University, 2012)Monoquinones and diquinones are a biologically and chemically important class of compounds that can be found in numerous natural products such as: thymoquinone, oosporein, coenzyme Q, embelin and the respective dimer, ... -
Solvent-Controlled Switch of Selectivity between sp[superscript]2 and s[superscript]p3 C-H Bond Activation by Platinum (II)
Garner, Alexander William (East Carolina University, 2010)Cyclometalation reactions have been studied intensely for the past few decades, especially those containing palladium. The factors that control the process of the C-H bond activation, however, are not yet completely ... -
SPECTROSCOPIC INVESTIGATIONS OF BINDING MECHANISMS BETWEEN ANTIMICROBIAL PEPTIDES AND MODELS OF THE MEMBRANES OF PSEUDOMONAS AERUGINOSA AND KLEBSIELLA PNEUMONIAE
Chai, Hanbo (East Carolina University, 2014)The wide application of antibiotics goes back over sixty years to the first use of penicillin in the mid-1940s. Antimicrobial agents have well-documented activity and have played a significant role in defending against ... -
Square Wave Voltammetry Detection and CD Spectroscopy Structural Characterization of 5- Methyl Cytosine-Containing Oligomeric DNA Sequences
Preston, Victoria G (East Carolina University, 2023-01-04)DNA methylation, primarily at the 5-carbon in cytosine (5-methyl cytosine) plays a significant role in key processes and functions of the body, such as development of the brain and in neuronal cell differentiation. Lack ... -
STABILITY OF POLYCYCLIC AROMATIC HYDROCARBONS AND BENZOIC ACID DERIVATIVES UNDER SUBCRITICAL WATER CONDITIONS
Lindquist, Edward J. (East Carolina University, 2011)The development of green environmental remediation, chromatography, and extraction techniques using subcritical water is the focus of our research group. The polarity of subcritical water can be manipulated by increasing ... -
Structure-Function Relationship of Surface N-glycans and Enzyme Active Site Proficiency: A Kinetic and Hydrogen-Deuterium Exchange Investigation of MoLOX
Whittington, Chris (East Carolina University, 2021-07-08)A 'unique' enzyme has emerged within the lipoxygenase (LOX) family. This manganese containing enzyme comes from the pathogen Magnaporthe oryzae and termed MoLOX. MoLOX is secreted at the onset of pathogenesis when the rice ... -
Studying Collagen with PyrATS: Pyrene-Appended Trimeric Systems
Keever, Jared Matthew (East Carolina University, 2019-07-30)Collagens are a family of triple-helical structural proteins that are ubiquitous in vertebrates. Improper folding of collagen can lead to disorders such as osteogenesis imperfecta, or "brittle bone disease." There is ... -
Surfactant Assisted Electrospray Ionization Time of Flight Mass Spectrometry of Synthetic Polymers
Brooks, James L. (East Carolina University, 2010)Synthetic polymers are complex mixtures which often require extensive characterization to determine chemical composition and structure. Mass spectrometric techniques have greatly enhanced the quantity, as well as the ... -
SYNTHESIS AND ANALYSIS OF FLUORESCENT ANTIFREEZE GLYCOPROTEIN MIMIC PEPTIDES FOR DETERMINATION OF THE ICE BINDING MECHANISM
Koufas, Megan Gabriele (East Carolina University, 2021-09-13)Properties of antifreeze glycoproteins (AFGPs) are well known; however, it is unclear which molecular components of the proteins are directly responsible for binding to the ice surface. Previous molecular dynamics studies ... -
SYNTHESIS AND PHOTOPHYSICAL CHARACTERIZATION OF TRIDENTATE C^N*N PLATINUM (II) COMPLEXES and, INVESTIGATION OF SELECTIVITY IN C-H BOND ACTIVATION BY PLATINUM
Ravindranathan, Deepak (East Carolina University, 2012)The synthesis, structure, and photophysical properties of a series of novel, highly luminescent tridentate platinum complexes with general coordination geometry of (C^N*N)-PtL are reported, where "C^N" denotes a coordination ... -
Synthesis and Reactions of Novel Heteroarylzirconocene Reagents
Harris, Caleb F. (East Carolina University, 2012)The cross-coupling of metallated heteroaromatic species with aryl and heteroaryl halides is a powerful and highly desirable transformation in both the synthesis of pharmaceutical compounds as well as materials development. ... -
SYNTHESIS AND SPECTROSCOPIC PROPERTIES OF BOC- PROTECTED FLUORESCENT ARGININE
Marshall, Sarah Ruth (East Carolina University, 2017-08-21)Small peptides capable of penetrating or spanning the hydrophobic core of lipid bilayers have many potential uses in medicine and in biochemical research. As the most basic of the amino acids that can comprise such peptides, ... -
Synthesis Of Non-Natural Fmoc-Protected Amino Acids To Provide Novel Fluorescent Anion Probes And Their Incorporation Into Synthetic Peptides
Farrell, David Percy (East Carolina University, 2015)Cystic fibrosis is a genetic disorder caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. CFTR serves to control the gradient of chloride and bicarbonate ions across the cellular ...