Browsing Dissertations by Title
Now showing items 956-975 of 1044
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The respective roles of BfmRS and PmrA in stress responses and antibiotic resistance in Acinetobacter baumannii
(East Carolina University, 2021-09-22)The Gram-negative bacterium Acinetobacter baumannii is considered one of the most serious nosocomial pathogens worldwide. Predominantly responsible for ventilator-associated pneumonia, this insidious pathogen typically ... -
The rhetoric of climate change: Using Latour to compose a nonmodern approach to our modern climate crisis
(East Carolina University, 2019-07-23)Climate change is the greatest threat facing humanity in the 21st century. Scientists from a variety of specialized fields, from biology and chemistry, to climatology and geology, are currently conducting research to ... -
The Role of Differential Sensitivity to Retinoic Acid (RA) in Regulating Spermatogonial Fate
(East Carolina University, 2018-12-10)In the mammalian testis, the foundation of spermatogenesis is provided by spermatogonial stem cells (SSCs); their progeny either remain as stem cells (following a self-renewal division) or proliferate as undifferentiated ... -
THE ROLE OF N6-METHYLADENOSINE IN HYPOXIA AND CELLULAR TRANSFORMATION
(East Carolina University, 2017-11-29)Cancer is a prevalent disease that affects millions of people each year across the globe. In an effort to find therapies to the many types of cancers, regulation of protein expression through transcription and translation ... -
THE ROLE OF RETINOIC ACID IN DIRECTING INITIATION OF SPERMATOGENESIS IN THE MOUSE
(East Carolina University, 2015-10-23)The basic tenets of gametogenesis are conserved among metazoans. After lineage commitment, germ cells proliferate, complete meiosis, and then differentiate into gametes capable of fertilization. In the mouse, spermatogenesis ... -
THE ROLE OF THE ALVEOLAR MACROPHAGE IN CARBON NANOTUBE ELICITED MURINE MODEL OF PULMONARY GRANULOMATOUS INFLAMMATION
(East Carolina University, 2018-11-29)Pulmonary sarcoidosis is a debilitating inflammatory condition characterized by the presence of granulomatous lesions throughout the lung. Granulomas are a physiological response to inhaled antigens or particulate matter ... -
THE ROLE OF THE LATERAL LINE IN EARLY LARVAL ZEBRAFISH AND CONTRIBUTION TO MULTISENSORY BEHAVIORS
(East Carolina University, 2023-07-21)The lateral line is a hair cell-based sensory system that is important for multisensory behaviors like schooling, rheotaxis, and predator/prey detection in aquatic vertebrates. This dissertation work uses the first genetic ... -
THE SWEET SPOT OF MENTORING MINDS AND BUILDING SUPPORT
(East Carolina University, 2023-11-27)The Focus of Practice (FoP) of this Participatory Action Research (PAR) project was to develop mentors' knowledge, skills, and dispositions to identify and implement equitable classroom practices through coaching conversations ... -
THE THERAPEUTIC ROLE OF RHO GTPASES IN TUMORIGENESIS AND CHEMOTHEARPY-INDUCED PERIPHERAL NEUROPATHY
(East Carolina University, 2019-07-15)With the advancement of chemotherapy drugs, the general life expectancy of cancer patients has drastically improved. However, persistent side effects, such as chemotherapy-induced peripheral neuropathy (CIPN), often severely ... -
The Tree to Success: Using Decision Tree Analysis to Predict Employee Performance and Health
(East Carolina University, 2015-12-10)The purpose of the current study was to evaluate the relative advantages and disadvantages of a novel statistical technique within the context of personnel decision-making. Specifically, the use of decision tree analysis ... -
The Tumor Suppressive Effects of T Cell Death-Associated Gene 8 in Blood Cancers
(East Carolina University, 2017-03-16)In the early twentieth century Otto Warburg recognized a metabolic phenomenon that transpired in cancer cells, currently known as the Warburg Effect. Warburg discovered cancer cells favor glycolysis rather than oxidative ... -
THE π-H ELIX IN FMN-DEPENDENT REDUCTASES PROMOTES OLIGOMERIC CHANGES TO COORDINATE THE MECHANISMS OF THE ALKANESULFONATE MONOOXYGENASE SYSTEMS
(East Carolina University, 2023-08-08)Bacteria two-component flavin-dependent systems are upregulated for sulfur acquisition under sulfur limiting conditions. Two-component flavin-dependent systems are comprised of a reductase (SsuE/MsuE) that catalyzes the ... -
THEOLOGICAL DISCUSSION AND INSTITUTIONAL CHANGE AT A CHURCH-RELATED INSTITUTION
(East Carolina University, 2012)This study explores the relationship between theological discussion and organizational change within a church-related institution. The qualitative case study examines the dialogue on a campus that received a Lilly Endowment ... -
THERAPEUTIC AND TOXICOLOGICAL EVALUATION OF BROAD-SPECTRUM ANTIMICROBIAL TRICLOSAN AS A CHEMOTHERAPEUTIC AGENT
(East Carolina University, 2019-05-07)Triclosan (TCS) is a phenolic antimicrobial incorporated in personal care products and medical devices. Interest in the antiproliferative properties of TCS has recently grown owing to its antilipogenic effects. Through the ... -
The therapeutic potential of Rho GTPase intervention
(East Carolina University, 2013)Small GTPases of the Rho family are well established regulators of critical cellular functions including cytoskeletal remodeling, motility, vesicle trafficking and cell cycle control. Additionally, aberrant signaling ... -
THERE’S TWO SIDES TO EVERY STORY: EXPANDING THE NOMOLOGICAL NETWORK OF BURNOUT THROUGH THE PERSON-ENVIRONMENT INTERACTION
(East Carolina University, 8/5/2020)Burnout is a psychological syndrome consisting of emotional exhaustion, cynicism, and reduced personal accomplishment. It is associated with a depletion of intrinsic resources that results from prolonged exposure to ... -
Thermodynamic and Spectroscopic Investigations of Novel Antimicrobial Peptides containing Unnatural Amino Acids with Model Membrane Systems
(East Carolina University, 2011)With the over prescription and use of antibiotic drugs the evolution of drug resistant bacteria strains has become a world wide health crisis. In response to this crisis, the search for new drugs to kill bacteria via a ... -
They're Speaking Gender Identity, Agency, and Belonging in an International Middle School
(East Carolina University, 2023-04-17)The purpose of the study was to better understand how international school middle school teachers can help cultivate a student's sense of belonging by creating a space for students to explore factors shaping their gender ...