Browsing Microbiology and Immunology by Title
Now showing items 214-233 of 268
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The Redox-Sensitive Transcriptional Activator OxyR Regulates the Peroxide Response Regulon in the Obligate Anaerobe Bacteroides fragilis
(East Carolina University, 2000-09)The peroxide response-inducible genes ahpCF, dps, and katB in the obligate anaerobe Bacteroides fragilis are controlled by the redox-sensitive transcriptional activator OxyR. This is the first functional oxidative ... -
Regulation of KSHV replication by glycoprotein B: chronicles of a virus and its host
(East Carolina University, 2011)Kaposi's sarcoma-associated herpesvirus (KSHV), the causative agent of three cancers: Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and the plasmablastic form of multicentric Castleman disease (MCD), shares many ... -
The regulation of anthranilate synthesis for the production of pqs in pseudomonas aeruginosa
(East Carolina University, 2013)The ubiquitous bacterium P. aeruginosa is an important human pathogen that causes devastating infections in immunocompromised patients and chronic infections in cystic fibrosis patients. The ability of P. aeruginosa to ... -
Regulation of Bacteriodes fragilis katB mRNA by oxidative stress and carbon limitation.
(East Carolina University, 1997-11)Regulation of the katB catalase gene in the anaerobic bacterium Bacteroides fragilis was studied. Northern blot hybridization analyses revealed that katB was transcribed as an approximately 1.6-kb monocistronic mRNA. The ... -
Regulation of Pseudomonas Quinolone Signal Synthesis in Pseudomonas aeruginosa
(East Carolina University, 2005-07)Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic lung infections in cystic fibrosis patients and is a major source of nosocomial infections. This bacterium controls many virulence factors by using ... -
Regulation of the Mitogen Activated Protein Kinase Kinase (MEK)-1 by NAD-Dependent Deacetylases
(2014-02)Sirtuins are class III deacetylases that regulate many essential processes, including cellular stress, genome stability, and metabolism. Although these NAD+-dependent deacetylases control adaptive cellular responses, ... -
Resveratrol Inhibits KSHV Reactivation by Lowering the Levels of Cellular EGR-1
(2012)Article Authors Metrics Comments Related Content Abstract Introduction Results Discussion Materials and Methods Supporting Information Acknowledgments Author Contributions References Reader Comments (0) Media ... -
Review: Carbon Nanotubes and Chronic Granulomatous Disease
(2014-06-23)Use of nanomaterials in manufactured consumer products is a rapidly expanding industry and potential toxicities are just beginning to be explored. Combustion-generated multiwall carbon nanotubes (MWCNT) or nanoparticles ... -
Role of the Iron Storage Ferritins Dps and DpsL during the Prolonged Oxidative Stress Response of Bacteroides fragilis
(East Carolina University, 2015-12-02)Bacteroides fragilis is a Gram negative anaerobe and member of the human intestinal tract microbiome. B. fragilis serves many beneficial roles within the intestinal tract; however, its translocation to the peritoneal cavity ... -
Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer
(2014-03)Cancer remains one of the major cause of death in the Western world. Although, it has been demonstrated that new therapies can improve the outcome of cancer patients, still many patients relapse after treatment. Therefore, ... -
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
(2011-03)Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation ... -
Roles of the RAF/MEK/ERK Pathway in Cell Growth, Malignant Transformation and Drug Resistance
(East Carolina University, 2007-08)Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their receptors to regulate gene expression and prevent apoptosis. Some components of these pathways are mutated or aberrantly ... -
Selection and stabilization of CD25high FOXP3+ regulatory T cells in vitro as a basis for adoptive antigen-specific immunotherapy
(East Carolina University, 2017-08-16)Autoimmune disease affects an estimated 50 million people in the United States. Autoimmune disease arises when immune tolerance is abrogated and host immune cells mount an attack against self-tissues. For example, in ... -
Similarity to peroxisomal-membrane protein family reveals that Sinorhizobium and Brucella BacA affect lipid-A fatty acids
(East Carolina University, 2004-04-06)Sinorhizobium meliloti, a legume symbiont, and Brucella abortus, a phylogenetically related mammalian pathogen, both require the bacterial-encoded BacA protein to establish chronic intracellular infections in their respective ... -
A SINGLE-CHAIN GMCSF-MOG TOLEROGENIC VACCINE EXPANDS MOG-SPECIFIC CD25+ FOXP3+ REGULATORY T CELLS THROUGH LOW-EFFICIENCY ANTIGEN RECOGNITION EVENTS TO INHIBIT EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
(2019-12)Previous studies showed that tolerogenic vaccines comprised of single-chain GMCSF-neuroantigen (NAg) fusion proteins inhibited experimental autoimmune encephalomyelitis (EAE) in rodents. The studies detailed here provide ... -
Solubility and Bioactivity of the Pseudomonas Quinolone Signal Are Increased by a Pseudomonas aeruginosa-Produced Surfactant
(East Carolina University, 2005-02)Pseudomonas aeruginosa is a gram-negative bacterium that causes serious infections in immunocompromised individuals and cystic fibrosis patients. This opportunistic pathogen controls many of its virulence factors and ...