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Murine Pancreatic Adenocarcinoma Reduces Ikaros Expression and Disrupts T Cell Homeostasis
(2015-01-28)
Background
Maintenance of T cell immune homeostasis is critical for adequate anti-tumor immunity. The transcription factor Ikaros is essential for lymphocyte development including T cells. Alterations in Ikaros expression ...
Trans-Amazon Drilling Project (TADP): origins and evolution of the forests, climate, and hydrology of the South American tropics
(2015)
This article presents the scientific rationale for an ambitious ICDP drilling project to continuously sample Late Cretaceous to modern sediment in four different sedimentary basins that transect the equatorial Amazon of ...
Mismatched anti-predator behavioral responses in predator-naïve larval anurans
(2015)
Organisms are adept at altering behaviors to balance the tradeoff between foraging and predation risk in spatially and temporally shifting predator environments. In order to optimize this tradeoff, prey need to be able to ...
Uptake of and resistance to the antibiotic berberine by individual dormant, germinating and outgrowing bacillus spores as monitored by laser tweezers raman spectroscopy
(2015-12-04)
Berberine, an alkaloid originally extracted from the plant Coptis chinensis and other herb
plants, has been used as a pharmacological substance for many years. The therapeutic
effect of berberine has been attributed to ...
Trends in Dengue Cases Imported into the United States from Pan America 2001–2012
(2015)
The objective of this study was to improve risk assessments of travel on dengue (DEN) virus (DENV) distribution. We investigated the
exposure risk of US citizens traveling to DEN-endemic Pan American countries. The number ...
WormGender – Open-Source Software for Automatic Caenorhabditis elegans Sex Ratio Measurement
(2015)
Fast and quantitative analysis of animal phenotypes is one of the major challenges of current biology. Here we report the WormGender open-source software, which is designed for
accurate quantification of sex ratio in ...
eHealth Literacy and Web 2.0 Health Information Seeking Behaviors Among Baby Boomers and Older Adults
(2015-03-17)
Background: Baby boomers and older adults, a subset of the population at high risk for chronic disease, social isolation, and poor health outcomes, are increasingly utilizing the Internet and social media (Web 2.0) to ...
Comprehensive track-structure based evaluation of DNA damage by light ions from radiotherapy- relevant energies down to stopping
(2017-03-27)
Track structures and resulting DNA damage in human cells have been simulated for hydrogen, helium,
carbon, nitrogen, oxygen and neon ions with 0.25–256 MeV/u energy. The needed ion interaction cross sections have been ...
Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies
(2017-12)
Background: Extracellular acidosis is a condition found within the tumor microenvironment due to inadequate blood perfusion, hypoxia, and altered tumor cell metabolism. Acidosis has pleiotropic effects on malignant progres‐ ...