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Plant genome editing with TALEN and CRISPR
(2017-04-24)
Genome editing promises giant leaps forward in advancing biotechnology, agriculture, and basic research. The process relies on the use of sequence specific nucleases (SSNs) to make DNA double stranded breaks at user defined ...
N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs
(2017-09)
Post-transcriptional regulation of mRNA during oxygen deprivation, or hypoxia, can affect the survivability of cells. Hypoxia has been shown to increase stability of a subset of ischemia-related mRNAs, including VEGF. RNA ...
miRNA-36 inhibits KSHV, EBV, HSV-2 infection of cells via stifling expression of interferon induced transmembrane protein 1 (IFITM1)
(2017-12-21)
Kaposi’s sarcoma-associated herpesvirus (KSHV) is etiologically associated with all forms of Kaposi’s sarcoma worldwide. Little is currently known about the role of microRNAs (miRNAs) in KSHV entry.
We recently demonstrated ...
Neuron-derived transthyretin modulates astrocytic glycolysis in hormone-independent manner
(2017-11-20)
It has been shown that neurons alter the expression of astrocytic metabolic enzymes by secretion of until now unknown molecule(s) into extracellular fluid. Here, we present evidence that neuron-derived transthyretin (TTR) ...
PI3K isoform inhibition associated with anti Bcr-Abl drugs shows in vitro increased anti-leukemic activity in Philadelphia chromosome-positive B-acute lymphoblastic leukemia cell lines
(2017-02-20)
B-acute lymphoblastic leukemia (B-ALL) is a malignant disorder characterized by the abnormal proliferation of B-cell progenitors. Philadelphia chromosome-positive (Ph+) B-ALL is a subtype that expresses the Bcr-Abl fusion ...
Ml proteins from Mesorhizobium loti and MucR from Brucella abortus: an AT-rich core DNA-target site and oligomerization ability
(2017-11-17)
Mesorhizobium loti contains ten genes coding for proteins sharing high amino acid sequence identity with members of the Ros/MucR transcription factor family. Five of these Ros/MucR family members from Mesorhizobium loti ...
Plasma Irisin Modestly Increases during Moderate and High-Intensity Afternoon Exercise in Obese Females
(2017-01-26)
Background and Purpose
Irisin is an exercise-responsive myokine that has been proposed to exert anti-obesity bene- fits; yet its response during exercise in obese women is not described. This study character- ized plasma ...
Regulation of cardiac fibroblast-mediated maladaptive ventricular remodeling by β-arrestins
(2019-07-03)
Cardiac fibroblasts (CF) play a critical role in post-infarction remodeling which can ultimately
lead to pathological fibrosis and heart failure. Recent evidence demonstrates that remote
(non-infarct) territory fibrosis ...
Pineal Region Glioblastoma, a Case Report and Literature Review
(2017-06-12)
Introduction: Pineal region glioblastoma multiforme (GBM) is a rare disease entity with a generally poor prognosis. We present a case of a patient with an unresectable pineal region GBM treated with chemoradiation with ...
Partial cD25 antagonism enables Dominance of antigen-inducible cD25high FOXP3+ regulatory T cells as a Basis for a regulatory T cell- Based adoptive immunotherapy
(2017-12-14)
FOXP3+ regulatory T cells (Tregs) represent a promising platform for effective adoptive immunotherapy of chronic inflammatory disease, including autoimmune diseases such as multiple sclerosis. Successful Treg immunotherapy ...